This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tridandapani, S.
Right arrow Articles by Coggeshall, K. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tridandapani, S.
Right arrow Articles by Coggeshall, K. M.

 Previous Article  |  Next Article 

Mol. Cell. Biol., Aug 1997, 4305-4311, Vol 17, No. 8
Copyright © 1997, American Society for Microbiology

Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif

S Tridandapani, T Kelley, M Pradhan, D Cooney, LB Justement and KM Coggeshall
Department of Microbiology, Ohio State University, Columbus 43210, USA.

Recently, we and others have demonstrated that negative signaling in B cells selectively induces the tyrosine phosphorylation of a novel inositol polyphosphate phosphatase, p145SHIP. In this study, we present data indicating that p145SHIP binds directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of Fc gammaRIIB1. Using recombinant SH2 domains, we show that binding is mediated via the Src homology region 2 (SH2)- containing inositol phosphatase (SHIP) SH2 domain. SHIP also bound to a phosphopeptide derived from CD22, raising the possibility that SHIP contributes to negative signaling by this receptor as well as Fc gammaRIIB1. The association of SHIP with the ITIM phosphopeptide was activation independent, while coassociation with Shc was activation dependent. Furthermore, experiments with Fc gammaRIIB1-deficient B cells demonstrated a genetic requirement for expression of Fc gammaRIIB1 in the induction of SHIP phosphorylation and its interaction with Shc. Based on these results, we propose a model of negative signaling in which co-cross-linking of surface immunoglobulin and Fc gammaRIIB1 results in sequential tyrosine phosphorylation of the ITIM, recruitment and phosphorylation of p145SHIP, and subsequent binding of Shc.


This article has been cited by other articles:

  • Fournier, E. M., Siberil, S., Costes, A., Varin, A., Fridman, W.-H., Teillaud, J.-L., Sautes-Fridman, C. (2008). Activation of Human Peripheral IgM+ B Cells Is Transiently Inhibited by BCR-Independent Aggregation of Fc{gamma}RIIB. J. Immunol. 181: 5350-5359 [Abstract] [Full Text]  
  • Kamen, L. A., Levinsohn, J., Cadwallader, A., Tridandapani, S., Swanson, J. A. (2008). SHIP-1 Increases Early Oxidative Burst and Regulates Phagosome Maturation in Macrophages. J. Immunol. 180: 7497-7505 [Abstract] [Full Text]  
  • Kamen, L. A., Levinsohn, J., Swanson, J. A. (2007). Differential Association of Phosphatidylinositol 3-Kinase, SHIP-1, and PTEN with Forming Phagosomes. Mol. Biol. Cell 18: 2463-2472 [Abstract] [Full Text]  
  • Ganesan, L. P., Joshi, T., Fang, H., Kutala, V. K., Roda, J., Trotta, R., Lehman, A., Kuppusamy, P., Byrd, J. C., Carson, W. E., Caligiuri, M. A., Tridandapani, S. (2006). Fc{gamma}R-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways. Blood 108: 718-725 [Abstract] [Full Text]  
  • Yogo, K., Mizutamari, M., Mishima, K., Takenouchi, H., Ishida-Kitagawa, N., Sasaki, T., Takeya, T. (2006). Src Homology 2 (SH2)-Containing 5'-Inositol Phosphatase Localizes to Podosomes, and the SH2 Domain Is Implicated in the Attenuation of Bone Resorption in Osteoclasts. Endocrinology 147: 3307-3317 [Abstract] [Full Text]  
  • Fujimoto, M., Kuwano, Y., Watanabe, R., Asashima, N., Nakashima, H., Yoshitake, S., Okochi, H., Tamaki, K., Poe, J. C., Tedder, T. F., Sato, S. (2006). B Cell Antigen Receptor and CD40 Differentially Regulate CD22 Tyrosine Phosphorylation. J. Immunol. 176: 873-879 [Abstract] [Full Text]  
  • Vedham, V., Phee, H., Coggeshall, K. M. (2005). Vav Activation and Function as a Rac Guanine Nucleotide Exchange Factor in Macrophage Colony-Stimulating Factor-Induced Macrophage Chemotaxis. Mol. Cell. Biol. 25: 4211-4220 [Abstract] [Full Text]  
  • Liu, Y., Masuda, E., Blank, M. C., Kirou, K. A., Gao, X., Park, M.-S., Pricop, L. (2005). Cytokine-mediated regulation of activating and inhibitory Fc{gamma} receptors in human monocytes. J. Leukoc. Biol. 77: 767-776 [Abstract] [Full Text]  
  • Hunter, M. G., Jacob, A., O'Donnell, L. C., Agler, A., Druhan, L. J., Coggeshall, K. M., Avalos, B. R. (2004). Loss of SHIP and CIS Recruitment to the Granulocyte Colony-Stimulating Factor Receptor Contribute to Hyperproliferative Responses in Severe Congenital Neutropenia/Acute Myelogenous Leukemia. J. Immunol. 173: 5036-5045 [Abstract] [Full Text]  
  • Fang, H., Pengal, R. A., Cao, X., Ganesan, L. P., Wewers, M. D., Marsh, C. B., Tridandapani, S. (2004). Lipopolysaccharide-Induced Macrophage Inflammatory Response Is Regulated by SHIP. J. Immunol. 173: 360-366 [Abstract] [Full Text]  
  • Nakamura, K., Kouro, T., Kincade, P. W., Malykhin, A., Maeda, K., Coggeshall, K. M. (2004). Src Homology 2-containing 5-Inositol Phosphatase (SHIP) Suppresses an Early Stage of Lymphoid Cell Development through Elevated Interleukin-6 Production by Myeloid Cells in Bone Marrow. JEM 199: 243-254 [Abstract] [Full Text]  
  • Baran, C. P., Tridandapani, S., Helgason, C. D., Humphries, R. K., Krystal, G., Marsh, C. B. (2003). The Inositol 5'-Phosphatase SHIP-1 and the Src Kinase Lyn Negatively Regulate Macrophage Colony-stimulating Factor-induced Akt Activity. J. Biol. Chem. 278: 38628-38636 [Abstract] [Full Text]  
  • Nakamura, K., Malykhin, A., Coggeshall, K. M. (2002). The Src homology 2 domain-containing inositol 5-phosphatase negatively regulates Fcgamma receptor-mediated phagocytosis through immunoreceptor tyrosine-based activation motif-bearing phagocytic receptors. Blood 100: 3374-3382 [Abstract] [Full Text]  
  • Tridandapani, S., Wang, Y., Marsh, C. B., Anderson, C. L. (2002). Src Homology 2 Domain-Containing Inositol Polyphosphate Phosphatase Regulates NF-{kappa}B-Mediated Gene Transcription by Phagocytic Fc{gamma}Rs in Human Myeloid Cells. J. Immunol. 169: 4370-4378 [Abstract] [Full Text]  
  • Ishihara, H., Sasaoka, T., Ishiki, M., Wada, T., Hori, H., Kagawa, S., Kobayashi, M. (2002). Membrane Localization of Src Homology 2-Containing Inositol 5'-Phosphatase 2 via Shc Association Is Required for the Negative Regulation of Insulin Signaling in Rat1 Fibroblasts Overexpressing Insulin Receptors. Mol. Endocrinol. 16: 2371-2381 [Abstract] [Full Text]  
  • Ott, V. L., Tamir, I., Niki, M., Pandolfi, P. P., Cambier, J. C. (2002). Downstream of Kinase, p62dok, Is a Mediator of Fc{gamma}RIIB Inhibition of Fc{epsilon}RI Signaling. J. Immunol. 168: 4430-4439 [Abstract] [Full Text]  
  • Tridandapani, S., Siefker, K., Teillaud, J.-L., Carter, J. E., Wewers, M. D., Anderson, C. L. (2002). Regulated Expression and Inhibitory Function of Fcgamma RIIb in Human Monocytic Cells. J. Biol. Chem. 277: 5082-5089 [Abstract] [Full Text]  
  • Gardai, S., Whitlock, B. B., Helgason, C., Ambruso, D., Fadok, V., Bratton, D., Henson, P. M. (2002). Activation of SHIP by NADPH Oxidase-stimulated Lyn Leads to Enhanced Apoptosis in Neutrophils. J. Biol. Chem. 277: 5236-5246 [Abstract] [Full Text]  
  • Gary-Gouy, H., Harriague, J., Dalloul, A., Donnadieu, E., Bismuth, G. (2002). CD5-Negative Regulation of B Cell Receptor Signaling Pathways Originates from Tyrosine Residue Y429 Outside an Immunoreceptor Tyrosine-Based Inhibitory Motif. J. Immunol. 168: 232-239 [Abstract] [Full Text]  
  • Phee, H., Rodgers, W., Coggeshall, K. M. (2001). Visualization of Negative Signaling in B Cells by Quantitative Confocal Microscopy. Mol. Cell. Biol. 21: 8615-8625 [Abstract] [Full Text]  
  • Brauweiler, A., Tamir, I., Marschner, S., Helgason, C. D., Cambier, J. C. (2001). Partially Distinct Molecular Mechanisms Mediate Inhibitory Fc{{gamma}}RIIB Signaling in Resting and Activated B Cells. J. Immunol. 167: 204-211 [Abstract] [Full Text]  
  • Nakamura, K., Brauweiler, A., Cambier, J. C. (2000). Effects of Src Homology Domain 2 (SH2)-Containing Inositol Phosphatase (SHIP), SH2-Containing Phosphotyrosine Phosphatase (SHP)-1, and SHP-2 SH2 Decoy Proteins on Fc{gamma}RIIB1-Effector Interactions and Inhibitory Functions. J. Immunol. 164: 631-638 [Abstract] [Full Text]  
  • Tanguay, D., Pavlovic, S., Piatelli, M. J., Bartek, J., Chiles, T. C. (1999). B Cell Antigen Receptor-Mediated Activation of Cyclin-Dependent Retinoblastoma Protein Kinases and Inhibition by Co-Cross-Linking with Fc{gamma} Receptors. J. Immunol. 163: 3160-3168 [Abstract] [Full Text]  
  • Park, R.-K., Izadi, K. D., Deo, Y. M., Durden, D. L. (1999). Role of Src in the Modulation of Multiple Adaptor Proteins in Fcalpha RI Oxidant Signaling. Blood 94: 2112-2120 [Abstract] [Full Text]  
  • Astoul, E., Watton, S., Cantrell, D. (1999). The Dynamics of Protein Kinase B Regulation during B Cell Antigen Receptor Engagement. JCB 145: 1511-1520 [Abstract] [Full Text]  
  • Yohannan, J., Wienands, J., Coggeshall, K. M., Justement, L. B. (1999). Analysis of Tyrosine Phosphorylation-dependent Interactions between Stimulatory Effector Proteins and the B Cell Co-receptor CD22. J. Biol. Chem. 274: 18769-18776 [Abstract] [Full Text]  
  • Maresco, D. L., Osborne, J. M., Cooney, D., Coggeshall, K. M., Anderson, C. L. (1999). The SH2-Containing 5'-Inositol Phosphatase (SHIP) Is Tyrosine Phosphorylated after Fc{gamma} Receptor Clustering in Monocytes. J. Immunol. 162: 6458-6465 [Abstract] [Full Text]  
  • Mikhalap, S. V., Shlapatska, L. M., Berdova, A. G., Law, C.-L., Clark, E. A., Sidorenko, S. P. (1999). CDw150 Associates with Src-Homology 2-Containing Inositol Phosphatase and Modulates CD95-Mediated Apoptosis. J. Immunol. 162: 5719-5727 [Abstract] [Full Text]  
  • Jacob, A., Cooney, D., Tridandapani, S., Kelley, T., Coggeshall, K. M. (1999). Fcgamma RIIb Modulation of Surface Immunoglobulin-induced Akt Activation in Murine B Cells. J. Biol. Chem. 274: 13704-13710 [Abstract] [Full Text]  
  • Harmer, S. L., DeFranco, A. L. (1999). The Src Homology Domain 2-Containing Inositol Phosphatase SHIP Forms a Ternary Complex with Shc and Grb2 in Antigen Receptor-stimulated B Lymphocytes. J. Biol. Chem. 274: 12183-12191 [Abstract] [Full Text]  
  • Tridandapani, S., Pradhan, M., LaDine, J. R., Garber, S., Anderson, C. L., Coggeshall, K. M. (1999). Protein Interactions of Src Homology 2 (SH2) Domain-Containing Inositol Phosphatase (SHIP): Association with Shc Displaces SHIP from Fc{gamma}RIIb in B Cells. J. Immunol. 162: 1408-1414 [Abstract] [Full Text]  
  • LOSMAN, J., CHEN, X.P., JIANG, H., PAN, P.-Y., KASHIWADA, M., GIALLOURAKIS, C., COWAN, S., FOLTENYI, K., ROTHMAN, P. (1999). IL-4 Signaling Is Regulated through the Recruitment of Phosphatases, Kinases, and SOCS Proteins to the Receptor Complex. Cold Spring Harb Symp Quant Biol 64: 405-416 [Abstract]  
  • Aman, M. J., Lamkin, T. D., Okada, H., Kurosaki, T., Ravichandran, K. S. (1998). The Inositol Phosphatase SHIP Inhibits Akt/PKB Activation in B Cells. J. Biol. Chem. 273: 33922-33928 [Abstract] [Full Text]  
  • Walker, F., Kato, A., Gonez, L. J., Hibbs, M. L., Pouliot, N., Levitzki, A., Burgess, A. W. (1998). Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation. Mol. Cell. Biol. 18: 7192-7204 [Abstract] [Full Text]  
  • Nichols, K. E., Harkin, D. P., Levitz, S., Krainer, M., Kolquist, K. A., Genovese, C., Bernard, A., Ferguson, M., Zuo, L., Snyder, E., Buckler, A. J., Wise, C., Ashley, J., Lovett, M., Valentine, M. B., Look, A. T., Gerald, W., Housman, D. E., Haber, D. A. (1998). Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc. Natl. Acad. Sci. USA 95: 13765-13770 [Abstract] [Full Text]  
  • Nakamura, K., Cambier, J. C. (1998). B Cell Antigen Receptor (BCR)-Mediated Formation of a SHP-2-pp120 Complex and Its Inhibition by Fe{gamma}RIIB1-BCR Coligation. J. Immunol. 161: 684-691 [Abstract] [Full Text]  
  • Hunter, M. G., Avalos, B. R. (1998). Phosphatidylinositol 3'-Kinase and SH2-Containing Inositol Phosphatase (SHIP) Are Recruited by Distinct Positive and Negative Growth-Regulatory Domains in the Granulocyte Colony-Stimulating Factor Receptor. J. Immunol. 160: 4979-4987 [Abstract] [Full Text]  
  • Phee, H., Jacob, A., Coggeshall, K. M. (2000). Enzymatic Activity of the Src Homology 2 Domain-containing Inositol Phosphatase Is Regulated by a Plasma Membrane Location. J. Biol. Chem. 275: 19090-19097 [Abstract] [Full Text]  
  • Poe, J. C., Fujimoto, M., Jansen, P. J., Miller, A. S., Tedder, T. F. (2000). CD22 Forms a Quaternary Complex with SHIP, Grb2, and Shc. A PATHWAY FOR REGULATION OF B LYMPHOCYTE ANTIGEN RECEPTOR-INDUCED CALCIUM FLUX. J. Biol. Chem. 275: 17420-17427 [Abstract] [Full Text]  
  • Giallourakis, C., Kashiwada, M., Pan, P.-Y., Danial, N., Jiang, H., Cambier, J., Coggeshall, K. M., Rothman, P. (2000). Positive Regulation of Interleukin-4-mediated Proliferation by the SH2-containing Inositol-5'-phosphatase. J. Biol. Chem. 275: 29275-29282 [Abstract] [Full Text]  
  • March, M. E., Lucas, D. M., Aman, M. J., Ravichandran, K. S. (2000). p135 Src Homology 2 Domain-containing Inositol 5'-Phosphatase (SHIPbeta ) Isoform Can Substitute for p145 SHIP in Fcgamma RIIB1-mediated Inhibitory Signaling in B Cells. J. Biol. Chem. 275: 29960-29967 [Abstract] [Full Text]  
  • Pesesse, X., Dewaste, V., De Smedt, F., Laffargue, M., Giuriato, S., Moreau, C., Payrastre, B., Erneux, C. (2001). The Src Homology 2 Domain Containing Inositol 5-Phosphatase SHIP2 Is Recruited to the Epidermal Growth Factor (EGF) Receptor and Dephosphorylates Phosphatidylinositol 3,4,5-Trisphosphate in EGF-stimulated COS-7 Cells. J. Biol. Chem. 276: 28348-28355 [Abstract] [Full Text]  
  • Kisseleva, M. V., Wilson, M. P., Majerus, P. W. (2000). The Isolation and Characterization of a cDNA Encoding Phospholipid-specific Inositol Polyphosphate 5-Phosphatase. J. Biol. Chem. 275: 20110-20116 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»