This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wagner, B. L.
Right arrow Articles by McDonnell, D. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wagner, B. L.
Right arrow Articles by McDonnell, D. P.

 Previous Article  |  Next Article 

Mol Cell Biol, March 1998, p. 1369-1378, Vol. 18, No. 3
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Nuclear Corepressors NCoR and SMRT Are Key Regulators of Both Ligand- and 8-Bromo-Cyclic AMP-Dependent Transcriptional Activity of the Human Progesterone Receptor

Brandee L. Wagner,1 John D. Norris,1 Trina A. Knotts,2 Nancy L. Weigel,2 and Donald P. McDonnell1,*

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710,1 and Department of Cell Biology, Baylor College of Medicine, Houston, Texas 770302

Received 4 August 1997/Returned for modification 9 September 1997/Accepted 3 December 1997

Previously, we defined a novel class of ligands for the human progesterone receptor (PR) which function as mixed agonists. These compounds induce a conformational change upon binding the receptor that is different from those induced by agonists and antagonists. This establishes a correlation between the structure of a ligand-receptor complex and its transcriptional activity. In an attempt to define the cellular components which distinguish between different ligand-induced PR conformations, we have determined, by using a mammalian two-hybrid assay, that the nuclear receptor corepressor (NCoR) and the silencing mediator for retinoid and thyroid hormone receptor (SMRT) differentially associate with PR depending upon the class of ligand bound to the receptor. Specifically, we observed that the corepressors preferentially associate with antagonist-occupied PR and that overexpression of these corepressors suppresses the partial agonist activity of antagonist-occupied PR. Binding studies performed in vitro, however, reveal that recombinant SMRT can interact with PR in a manner which is not influenced by the nature of the bound ligand. Thus, the inability of SMRT or NCoR to interact with agonist-activated PR when assayed in vivo may relate more to the increased affinity of PR for coactivators, with a subsequent displacement of corepressors, than to an inherent low affinity for the corepressor proteins. Previous work from other groups has shown that 8-bromo-cyclic AMP (8-bromo-cAMP) can convert the PR antagonist RU486 into an agonist and, additionally, can potentiate the transcriptional activity of agonist-bound PR. In this study, we show that exogenous expression of NCoR or SMRT suppresses all 8-bromo-cAMP-mediated potentiation of PR transcriptional activity. Further analysis revealed that 8-bromo-cAMP addition decreases the association of NCoR and SMRT with PR. Thus, we propose that 8-bromo-cAMP-mediated potentiation of PR transcriptional activity is due, at least in part, to a disruption of the interaction between PR and the corepressors NCoR and SMRT. Cumulatively, these results suggest that NCoR and SMRT expression may play a pivotal role in PR pharmacology.

* Corresponding author. Mailing address: Department of Pharmacology and Cancer Biology, Duke University Medical Center, P.O. Box 3813, Durham, NC 27710. Phone: (919) 684-6035. Fax: (919) 681-7139. E-mail: mcdon016{at}acpub.duke.edu.




This article has been cited by other articles:

  • Hodgson, M. C., Shen, H. C., Hollenberg, A. N., Balk, S. P. (2008). Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor. Molecular Cancer Therapeutics 7: 3187-3194 [Abstract] [Full Text]  
  • Song, L.-N., Gelmann, E. P. (2008). Silencing Mediator for Retinoid and Thyroid Hormone Receptor and Nuclear Receptor Corepressor Attenuate Transcriptional Activation by the {beta}-Catenin-TCF4 Complex. J. Biol. Chem. 283: 25988-25999 [Abstract] [Full Text]  
  • Takano, M., Lu, Z., Goto, T., Fusi, L., Higham, J., Francis, J., Withey, A., Hardt, J., Cloke, B., Stavropoulou, A. V., Ishihara, O., Lam, E. W.-F., Unterman, T. G., Brosens, J. J., Kim, J. J. (2007). Transcriptional Cross Talk between the Forkhead Transcription Factor Forkhead Box O1A and the Progesterone Receptor Coordinates Cell Cycle Regulation and Differentiation in Human Endometrial Stromal Cells. Mol. Endocrinol. 21: 2334-2349 [Abstract] [Full Text]  
  • Cheng, J., Zhang, C., Shapiro, D. J. (2007). A Functional Serine 118 Phosphorylation Site in Estrogen Receptor-{alpha} Is Required for Down-Regulation of Gene Expression by 17{beta}-Estradiol and 4-Hydroxytamoxifen. Endocrinology 148: 4634-4641 [Abstract] [Full Text]  
  • Jonas, B. A., Varlakhanova, N., Hayakawa, F., Goodson, M., Privalsky, M. L. (2007). Response of SMRT (Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor) and N-CoR (Nuclear Receptor Corepressor) Corepressors to Mitogen-Activated Protein Kinase Kinase Kinase Cascades Is Determined by Alternative mRNA Splicing. Mol. Endocrinol. 21: 1924-1939 [Abstract] [Full Text]  
  • Han, S. J., Tsai, S. Y., Tsai, M.-J., O'Malley, B. W. (2007). Distinct Temporal and Spatial Activities of RU486 on Progesterone Receptor Function in Reproductive Organs of Ovariectomized Mice. Endocrinology 148: 2471-2486 [Abstract] [Full Text]  
  • Lu, N. Z., Wardell, S. E., Burnstein, K. L., Defranco, D., Fuller, P. J., Giguere, V., Hochberg, R. B., McKay, L., Renoir, J.-M., Weigel, N. L., Wilson, E. M., McDonnell, D. P., Cidlowski, J. A. (2006). International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors. Pharmacol. Rev. 58: 782-797 [Full Text]  
  • Jones, M. C., Fusi, L., Higham, J. H., Abdel-Hafiz, H., Horwitz, K. B., Lam, E. W.-F., Brosens, J. J. (2006). Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc. Natl. Acad. Sci. USA 103: 16272-16277 [Abstract] [Full Text]  
  • Mani, S. K., Reyna, A. M., Chen, J. Z., Mulac-Jericevic, B., Conneely, O. M. (2006). Differential Response of Progesterone Receptor Isoforms in Hormone-Dependent and -Independent Facilitation of Female Sexual Receptivity. Mol. Endocrinol. 20: 1322-1332 [Abstract] [Full Text]  
  • Hall, J. M., McDonnell, D. P. (2005). Coregulators in Nuclear Estrogen Receptor Action: From Concept to Therapeutic Targeting. Mol. Interv. 5: 343-357 [Abstract] [Full Text]  
  • Han, S. J., Jeong, J., DeMayo, F. J., Xu, J., Tsai, S. Y., Tsai, M.-J., O'Malley, B. W. (2005). Dynamic Cell Type Specificity of SRC-1 Coactivator in Modulating Uterine Progesterone Receptor Function in Mice. Mol. Cell. Biol. 25: 8150-8165 [Abstract] [Full Text]  
  • Hultman, M. L., Krasnoperova, N. V., Li, S., Du, S., Xia, C., Dietz, J. D., Lala, D. S., Welsch, D. J., Hu, X. (2005). The Ligand-Dependent Interaction of Mineralocorticoid Receptor with Coactivator and Corepressor Peptides Suggests Multiple Activation Mechanisms. Mol. Endocrinol. 19: 1460-1473 [Abstract] [Full Text]  
  • Wang, D., Simons, S. S. Jr. (2005). Corepressor Binding to Progesterone and Glucocorticoid Receptors Involves the Activation Function-1 Domain and Is Inhibited by Molybdate. Mol. Endocrinol. 19: 1483-1500 [Abstract] [Full Text]  
  • Chwalisz, K., Perez, M. C., DeManno, D., Winkel, C., Schubert, G., Elger, W. (2005). Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis. Endocr. Rev. 26: 423-438 [Abstract] [Full Text]  
  • Chabbert-Buffet, N., Meduri, G., Bouchard, P., Spitz, I. M. (2005). Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications. Hum Reprod Update 11: 293-307 [Abstract] [Full Text]  
  • Shah, Y. M., Rowan, B. G. (2005). The Src Kinase Pathway Promotes Tamoxifen Agonist Action in Ishikawa Endometrial Cells through Phosphorylation-Dependent Stabilization of Estrogen Receptor {alpha} Promoter Interaction and Elevated Steroid Receptor Coactivator 1 Activity. Mol. Endocrinol. 19: 732-748 [Abstract] [Full Text]  
  • Ding, X., Staudinger, J. L. (2005). Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway. J. Pharmacol. Exp. Ther. 312: 849-856 [Abstract] [Full Text]  
  • Jung, C., Kim, R.-S., Zhang, H.-J., Lee, S.-J., Jeng, M.-H. (2004). HOXB13 Induces Growth Suppression of Prostate Cancer Cells as a Repressor of Hormone-Activated Androgen Receptor Signaling. Cancer Res. 64: 9185-9192 [Abstract] [Full Text]  
  • Masiello, D., Chen, S.-Y., Xu, Y., Verhoeven, M. C., Choi, E., Hollenberg, A. N., Balk, S. P. (2004). Recruitment of {beta}-Catenin by Wild-Type or Mutant Androgen Receptors Correlates with Ligand-Stimulated Growth of Prostate Cancer Cells. Mol. Endocrinol. 18: 2388-2401 [Abstract] [Full Text]  
  • Simmen, R. C. M., Eason, R. R., McQuown, J. R., Linz, A. L., Kang, T.-J., Chatman, L. Jr., Till, S. R., Fujii-Kuriyama, Y., Simmen, F. A., Oh, S. P. (2004). Subfertility, Uterine Hypoplasia, and Partial Progesterone Resistance in Mice Lacking the Kruppel-like Factor 9/Basic Transcription Element-binding Protein-1 (Bteb1) Gene. J. Biol. Chem. 279: 29286-29294 [Abstract] [Full Text]  
  • Wang, Q., Blackford, J. A. Jr., Song, L.-N., Huang, Y., Cho, S., Simons, S. S. Jr. (2004). Equilibrium Interactions of Corepressors and Coactivators with Agonist and Antagonist Complexes of Glucocorticoid Receptors. Mol. Endocrinol. 18: 1376-1395 [Abstract] [Full Text]  
  • Liu, X.-f., Bagchi, M. K. (2004). Recruitment of Distinct Chromatin-modifying Complexes by Tamoxifen-complexed Estrogen Receptor at Natural Target Gene Promoters in Vivo. J. Biol. Chem. 279: 15050-15058 [Abstract] [Full Text]  
  • Blaustein, J. D. (2004). Minireview: Neuronal Steroid Hormone Receptors: They're Not Just for Hormones Anymore. Endocrinology 145: 1075-1081 [Abstract] [Full Text]  
  • Smith, C. L., O'Malley, B. W. (2004). Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators. Endocr. Rev. 25: 45-71 [Abstract] [Full Text]  
  • Zhang, Y., Yang, Y., Yeh, S., Chang, C. (2004). ARA67/PAT1 Functions as a Repressor To Suppress Androgen Receptor Transactivation. Mol. Cell. Biol. 24: 1044-1057 [Abstract] [Full Text]  
  • Linja, M. J., Porkka, K. P., Kang, Z., Savinainen, K. J., Janne, O. A., Tammela, T. L. J., Vessella, R. L., Palvimo, J. J., Visakorpi, T. (2004). Expression of Androgen Receptor Coregulators in Prostate Cancer. Clin. Cancer Res. 10: 1032-1040 [Abstract] [Full Text]  
  • Song, L.-N., Coghlan, M., Gelmann, E. P. (2004). Antiandrogen Effects of Mifepristone on Coactivator and Corepressor Interactions with the Androgen Receptor. Mol. Endocrinol. 18: 70-85 [Abstract] [Full Text]  
  • Agoulnik, I. U., Krause, W. C., Bingman, W. E. III, Rahman, H. T., Amrikachi, M., Ayala, G. E., Weigel, N. L. (2003). Repressors of Androgen and Progesterone Receptor Action. J. Biol. Chem. 278: 31136-31148 [Abstract] [Full Text]  
  • Condon, J. C., Jeyasuria, P., Faust, J. M., Wilson, J. W., Mendelson, C. R. (2003). A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. Proc. Natl. Acad. Sci. USA 100: 9518-9523 [Abstract] [Full Text]  
  • De Bosscher, K., Vanden Berghe, W., Haegeman, G. (2003). The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression. Endocr. Rev. 24: 488-522 [Abstract] [Full Text]  
  • Stevens, A., Garside, H., Berry, A., Waters, C., White, A., Ray, D. (2003). Dissociation of Steroid Receptor Coactivator 1 and Nuclear Receptor Corepressor Recruitment to the Human Glucocorticoid Receptor by Modification of the Ligand-Receptor Interface: The Role of Tyrosine 735. Mol. Endocrinol. 17: 845-859 [Abstract] [Full Text]  
  • Farboud, B., Hauksdottir, H., Wu, Y., Privalsky, M. L. (2003). Isotype-Restricted Corepressor Recruitment: a Constitutively Closed Helix 12 Conformation in Retinoic Acid Receptors {beta} and {gamma} Interferes with Corepressor Recruitment and Prevents Transcriptional Repression. Mol. Cell. Biol. 23: 2844-2858 [Abstract] [Full Text]  
  • Webb, P., Nguyen, P., Kushner, P. J. (2003). Differential SERM Effects on Corepressor Binding Dictate ERalpha Activity in Vivo. J. Biol. Chem. 278: 6912-6920 [Abstract] [Full Text]  
  • Rajendran, R. R., Nye, A. C., Frasor, J., Balsara, R. D., Martini, P. G. V., Katzenellenbogen, B. S. (2003). Regulation of Nuclear Receptor Transcriptional Activity by a Novel DEAD Box RNA Helicase (DP97). J. Biol. Chem. 278: 4628-4638 [Abstract] [Full Text]  
  • Shiozawa, T., Shih, H.-C., Miyamoto, T., Feng, Y.-Z., Uchikawa, J., Itoh, K., Konishi, I. (2003). Cyclic Changes in the Expression of Steroid Receptor Coactivators and Corepressors in the Normal Human Endometrium. J. Clin. Endocrinol. Metab. 88: 871-878 [Abstract] [Full Text]  
  • Leonhardt, S. A., Edwards, D. P. (2002). Mechanism of Action of Progesterone Antagonists. Exp. Biol. Med. 227: 969-980 [Abstract] [Full Text]  
  • Wardell, S. E., Boonyaratanakornkit, V., Adelman, J. S., Aronheim, A., Edwards, D. P. (2002). Jun Dimerization Protein 2 Functions as a Progesterone Receptor N-Terminal Domain Coactivator. Mol. Cell. Biol. 22: 5451-5466 [Abstract] [Full Text]  
  • Sathya, G., Jansen, M. S., Nagel, S. C., Cook, C. E., MCDonnell, D. P. (2002). Identification and Characterization of Novel Estrogen Receptor-{beta}-Sparing Antiprogestins. Endocrinology 143: 3071-3082 [Abstract] [Full Text]  
  • Huang, H.-J., Norris, J. D., McDonnell, D. P. (2002). Identification of a Negative Regulatory Surface within Estrogen Receptor {alpha} Provides Evidence in Support of a Role for Corepressors in Regulating Cellular Responses to Agonists and Antagonists. Mol. Endocrinol. 16: 1778-1792 [Abstract] [Full Text]  
  • Schulz, M., Eggert, M., Baniahmad, A., Dostert, A., Heinzel, T., Renkawitz, R. (2002). RU486-induced Glucocorticoid Receptor Agonism Is Controlled by the Receptor N Terminus and by Corepressor Binding. J. Biol. Chem. 277: 26238-26243 [Abstract] [Full Text]  
  • Liu, Z., Auboeuf, D., Wong, J., Chen, J. D., Tsai, S. Y., Tsai, M.-J., O'Malley, B. W. (2002). Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486. Proc. Natl. Acad. Sci. USA 99: 7940-7944 [Abstract] [Full Text]  
  • Li, X., McDonnell, D. P. (2002). The Transcription Factor B-Myb Is Maintained in an Inhibited State in Target Cells through Its Interaction with the Nuclear Corepressors N-CoR and SMRT. Mol. Cell. Biol. 22: 3663-3673 [Abstract] [Full Text]  
  • Heinlein, C. A., Chang, C. (2002). Androgen Receptor (AR) Coregulators: An Overview. Endocr. Rev. 23: 175-200 [Abstract] [Full Text]  
  • Dotzlaw, H., Moehren, U., Mink, S., Cato, A. C. B., Iniguez Lluhi, J. A., Baniahmad, A. (2002). The Amino Terminus of the Human AR Is Target for Corepressor Action and Antihormone Agonism. Mol. Endocrinol. 16: 661-673 [Abstract] [Full Text]  
  • Norris, J. D., Fan, D., Sherk, A., McDonnell, D. P. (2002). A Negative Coregulator for the Human ER. Mol. Endocrinol. 16: 459-468 [Abstract] [Full Text]  
  • Marimuthu, A., Feng, W., Tagami, T., Nguyen, H., Jameson, J. L., Fletterick, R. J., Baxter, J. D., West, B. L. (2002). TR Surfaces and Conformations Required to Bind Nuclear Receptor Corepressor. Mol. Endocrinol. 16: 271-286 [Abstract] [Full Text]  
  • Hong, S.-H., Yang, Z., Privalsky, M. L. (2001). Arsenic Trioxide Is a Potent Inhibitor of the Interaction of SMRT Corepressor with Its Transcription Factor Partners, Including the PML-Retinoic Acid Receptor {alpha} Oncoprotein Found in Human Acute Promyelocytic Leukemia. Mol. Cell. Biol. 21: 7172-7182 [Abstract] [Full Text]  
  • Schreihofer, D. A., Resnick, E. M., Lin, V. Y., Shupnik, M. A. (2001). Ligand-Independent Activation of Pituitary ER: Dependence on PKA-Stimulated Pathways. Endocrinology 142: 3361-3368 [Abstract] [Full Text]  
  • Davidson, B. P., Dogra, S. C., May, B. K. (2001). The Antiglucocorticoid RU486 Inhibits Phenobarbital Induction of the Chicken CYP2H1 Gene in Primary Hepatocytes. Mol. Pharmacol. 60: 274-281 [Abstract] [Full Text]  
  • Cohen, R. N., Brzostek, S., Kim, B., Chorev, M., Wondisford, F. E., Hollenberg, A. N. (2001). The Specificity of Interactions between Nuclear Hormone Receptors and Corepressors Is Mediated by Distinct Amino Acid Sequences within the Interacting Domains. Mol. Endocrinol. 15: 1049-1061 [Abstract] [Full Text]  
  • Turgeon, J. L., Waring, D. W. (2001). Luteinizing Hormone Secretion from Wild-Type and Progesterone Receptor Knockout Mouse Anterior Pituitary Cells. Endocrinology 142: 3108-3115 [Abstract] [Full Text]  
  • Havrilesky, L. J., McMahon, C. P., Lobenhofer, E. K., Whitaker, R., Marks, J. R., Berchuck, A. (2001). Relationship Between Expression of Coactivators and Corepressors of Hormone Receptors and Resistance of Ovarian Cancers to Growth Regulation by Steroid Hormones. Reproductive Sciences 8: 104-113 [Abstract]  
  • Giannoukos, G., Szapary, D., Smith, C. L., Meeker, J. E. W., Simons, S. S. Jr. (2001). New Antiprogestins with Partial Agonist Activity: Potential Selective Progesterone Receptor Modulators (SPRMs) and Probes for Receptor- and Coregulator-Induced Changes in Progesterone Receptor Induction Properties. Mol. Endocrinol. 15: 255-270 [Abstract] [Full Text]  
  • Lu, D., Giguere, V. (2001). Requirement of Ras-Dependent Pathways for Activation of the Transforming Growth Factor {beta}3 Promoter by Estradiol. Endocrinology 142: 751-759 [Abstract] [Full Text]  
  • Rowan, B. G., Garrison, N., Weigel, N. L., O'Malley, B. W. (2000). 8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein. Mol. Cell. Biol. 20: 8720-8730 [Abstract] [Full Text]  
  • Hong, S.-H., Privalsky, M. L. (2000). The SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export. Mol. Cell. Biol. 20: 6612-6625 [Abstract] [Full Text]  
  • Mao, C., Shapiro, D. J. (2000). A Histone Deacetylase Inhibitor Potentiates Estrogen Receptor Activation of a Stably Integrated Vitellogenin Promoter in HepG2 Cells. Endocrinology 141: 2361-2369 [Abstract] [Full Text]  
  • Cohen, R. N., Putney, A., Wondisford, F. E., Hollenberg, A. N. (2000). The Nuclear Corepressors Recognize Distinct Nuclear Receptor Complexes. Mol. Endocrinol. 14: 900-914 [Abstract] [Full Text]  
  • Giangrande, P. H., A. Kimbrel, E., Edwards, D. P., McDonnell, D. P. (2000). The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding. Mol. Cell. Biol. 20: 3102-3115 [Abstract] [Full Text]  
  • Rowan, B. G., Weigel, N. L., O'Malley, B. W. (2000). Phosphorylation of Steroid Receptor Coactivator-1. IDENTIFICATION OF THE PHOSPHORYLATION SITES AND PHOSPHORYLATION THROUGH THE MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY. J. Biol. Chem. 275: 4475-4483 [Abstract] [Full Text]  
  • Greenland, K. J., Jantke, I., Jenatschke, S., Bracken, K. E., Vinson, C., Gellersen, B. (2000). The Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Gene Promoter Is Controlled by Ets and Activating Protein-1 Transcription Factors and Progesterone. Endocrinology 141: 581-597 [Abstract] [Full Text]  
  • Glass, C. K., Rosenfeld, M. G. (2000). The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14: 121-141 [Full Text]  
  • Edwards, D. P., Leonhardt, S. A., Gass-Handel, E. (2000). Novel Mechanisms of Progesterone Antagonists and Progesterone Receptor. Reproductive Sciences 7: S22-S24 [Abstract]  
  • Perissi, V., Staszewski, L. M., McInerney, E. M., Kurokawa, R., Krones, A., Rose, D. W., Lambert, M. H., Milburn, M. V., Glass, C. K., Rosenfeld, M. G. (1999). Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev. 13: 3198-3208 [Abstract] [Full Text]  
  • Szapary, D., Huang, Y., Simons, S. S. Jr. (1999). Opposing Effects of Corepressor and Coactivators in Determining the Dose-Response Curve of Agonists, and Residual Agonist Activity of Antagonists, for Glucocorticoid Receptor-Regulated Gene Expression. Mol. Endocrinol. 13: 2108-2121 [Abstract] [Full Text]  
  • Wijayaratne, A. L., Nagel, S. C., Paige, L. A., Christensen, D. J., Norris, J. D., Fowlkes, D. M., McDonnell, D. P. (1999). Comparative Analyses of Mechanistic Differences Among Antiestrogens. Endocrinology 140: 5828-5840 [Abstract] [Full Text]  
  • Webb, P., Nguyen, P., Valentine, C., Lopez, G. N., Kwok, G. R., McInerney, E., Katzenellenbogen, B. S., Enmark, E., Gustafsson, J.-A., Nilsson, S., Kushner, P. J. (1999). The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions. Mol. Endocrinol. 13: 1672-1685 [Abstract] [Full Text]  
  • Norris, J. D., Paige, L. A., Christensen, D. J., Chang, C., Huacani, M. R., Fan, D., Hamilton, P. T., Fowlkes, D. M., McDonnell, D. P. (1999). Peptide Antagonists of the Human Estrogen Receptor. Science 285: 744-746 [Abstract] [Full Text]  
  • McKenna, N. J., Lanz, R. B., O’Malley, B. W. (1999). Nuclear Receptor Coregulators: Cellular and Molecular Biology. Endocr. Rev. 20: 321-344 [Abstract] [Full Text]  
  • Oberfield, J. L., Collins, J. L., Holmes, C. P., Goreham, D. M., Cooper, J. P., Cobb, J. E., Lenhard, J. M., Hull-Ryde, E. A., Mohr, C. P., Blanchard, S. G., Parks, D. J., Moore, L. B., Lehmann, J. M., Plunket, K., Miller, A. B., Milburn, M. V., Kliewer, S. A., Willson, T. M. (1999). A peroxisome proliferator-activated receptor gamma  ligand inhibits adipocyte differentiation. Proc. Natl. Acad. Sci. USA 96: 6102-6106 [Abstract] [Full Text]  
  • Park, E.-J., Schroen, D. J., Yang, M., Li, H., Li, L., Chen, J. D. (1999). SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. Proc. Natl. Acad. Sci. USA 96: 3519-3524 [Abstract] [Full Text]  
  • Wagner, B. L., Pollio, G., Giangrande, P., Webster, J. C., Breslin, M., Mais, D. E., Cook, C. E., Vedeckis, W. V., Cidlowski, J. A., McDonnell, D. P. (1999). The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI 3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins. Endocrinology 140: 1449-1458 [Abstract] [Full Text]  
  • Zeitoun, K., Takayama, K., Michael, M. D., Bulun, S. E. (1999). Stimulation of Aromatase P450 Promoter (II) Activity in Endometriosis and Its Inhibition in Endometrium Are Regulated by Competitive Binding of Steroidogenic Factor-1 and Chicken Ovalbumin Upstream Promoter Transcription Factor to the Same cis-Acting Element. Mol. Endocrinol. 13: 239-253 [Abstract] [Full Text]  
  • Massaad, C., Houard, N., Lombès, M., Barouki, R. (1999). Modulation of Human Mineralocorticoid Receptor Function by Protein Kinase A. Mol. Endocrinol. 13: 57-65 [Abstract] [Full Text]  
  • Leonhardt, S. A., Altmann, M., Edwards, D. P. (1998). Agonist and Antagonists Induce Homodimerization and Mixed Ligand Heterodimerization of Human Progesterone Receptors in Vivo by a Mammalian Two-Hybrid Assay. Mol. Endocrinol. 12: 1914-1930 [Abstract] [Full Text]  
  • Darimont, B. D., Wagner, R. L., Apriletti, J. W., Stallcup, M. R., Kushner, P. J., Baxter, J. D., Fletterick, R. J., Yamamoto, K. R. (1998). Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 12: 3343-3356 [Abstract] [Full Text]  
  • Wong, C.-W., Privalsky, M. L. (1998). Components of the SMRT Corepressor Complex Exhibit Distinctive Interactions with the POZ Domain Oncoproteins PLZF, PLZF-RARalpha , and BCL-6. J. Biol. Chem. 273: 27695-27702 [Abstract] [Full Text]  
  • Webb, P., Nguyen, P., Shinsako, J., Anderson, C., Feng, W., Nguyen, M. P., Chen, D., Huang, S.-M., Subramanian, S., McKinerney, E., Katzenellenbogen, B. S., Stallcup, M. R., Kushner, P. J. (1998). Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins. Mol. Endocrinol. 12: 1605-1618 [Abstract] [Full Text]  
  • Hong, S.-H., Wong, C.-W., Privalsky, M. L. (1998). Signaling by Tyrosine Kinases Negatively Regulates the Interaction between Transcription Factors and SMRT (Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor) Corepressor. Mol. Endocrinol. 12: 1161-1171 [Abstract] [Full Text]  
  • Komine, M., Rao, L. S., Kaneko, T., Tomic-Canic, M., Tamaki, K., Freedberg, I. M., Blumenberg, M. (2000). Inflammatory Versus Proliferative Processes in Epidermis. TUMOR NECROSIS FACTOR alpha INDUCES K6b KERATIN SYNTHESIS THROUGH A TRANSCRIPTIONAL COMPLEX CONTAINING NFkappa B AND C/EBPbeta. J. Biol. Chem. 275: 32077-32088 [Abstract] [Full Text]  
  • Hansen, J. B., Zhang, H., Rasmussen, T. H., Petersen, R. K., Flindt, E. N., Kristiansen, K. (2001). Peroxisome Proliferator-activated Receptor delta (PPARdelta )-mediated Regulation of Preadipocyte Proliferation and Gene Expression Is Dependent on cAMP Signaling. J. Biol. Chem. 276: 3175-3182 [Abstract] [Full Text]  
  • Knotts, T. A., Orkiszewski, R. S., Cook, R. G., Edwards, D. P., Weigel, N. L. (2001). Identification of a Phosphorylation Site in the Hinge Region of the Human Progesterone Receptor and Additional Amino-terminal Phosphorylation Sites. J. Biol. Chem. 276: 8475-8483 [Abstract] [Full Text]  
  • Wang, Q., Lu, J., Yong, E. L. (2001). Ligand- and Coactivator-mediated Transactivation Function (AF2) of the Androgen Receptor Ligand-binding Domain Is Inhibited by the Cognate Hinge Region. J. Biol. Chem. 276: 7493-7499 [Abstract] [Full Text]  
  • Feng, X., Jiang, Y., Meltzer, P., Yen, P. M. (2001). Transgenic Targeting of a Dominant Negative Corepressor to Liver Blocks Basal Repression by Thyroid Hormone Receptor and Increases Cell Proliferation. J. Biol. Chem. 276: 15066-15072 [Abstract] [Full Text]  
  • Elholm, M., Dam, I., Jorgensen, C., Krogsdam, A.-M., Holst, D., Kratchmarova, I., Gottlicher, M., Gustafsson, J.-A., Berge, R., Flatmark, T., Knudsen, J., Mandrup, S., Kristiansen, K. (2001). Acyl-CoA Esters Antagonize the Effects of Ligands on Peroxisome Proliferator-activated Receptor alpha Conformation, DNA Binding, and Interaction with Co-factors. J. Biol. Chem. 276: 21410-21416 [Abstract] [Full Text]  
  • Song, L.-N., Huse, B., Rusconi, S., Simons, S. S. Jr. (2001). Transactivation Specificity of Glucocorticoid Versus Progesterone Receptors. ROLE OF FUNCTIONALLY DIFFERENT INTERACTIONS OF TRANSCRIPTION FACTORS WITH AMINO- AND CARBOXYL-TERMINAL RECEPTOR DOMAINS. J. Biol. Chem. 276: 24806-24816 [Abstract] [Full Text]  
  • Vadlamudi, R. K., Wang, R.-A., Mazumdar, A., Kim, Y.-s., Shin, J., Sahin, A., Kumar, R. (2001). Molecular Cloning and Characterization of PELP1, a Novel Human Coregulator of Estrogen Receptor alpha. J. Biol. Chem. 276: 38272-38279 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»