This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Joel, P. B.
Right arrow Articles by Lannigan, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Joel, P. B.
Right arrow Articles by Lannigan, D. A.

 Previous Article  |  Next Article 

Mol Cell Biol, April 1998, p. 1978-1984, Vol. 18, No. 4
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167

Peteranne B. Joel,1 Jeffrey Smith,2 Thomas W. Sturgill,2 Tracey L. Fisher,3 John Blenis,3 and Deborah A. Lannigan1,*

Center for Cell Signaling and Department of Pharmacology1 and Howard Hughes Medical Institute,2 University of Virginia, Charlottesville, Virginia 22908, and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 021153

Received 19 August 1997/Returned for modification 6 October 1997/Accepted 21 January 1998

The estrogen receptor alpha  (ER), a member of the steroid receptor superfamily, contains an N-terminal hormone-independent transcriptional activation function (AF-1) and a C-terminal hormone-dependent transcriptional activation function (AF-2). Here, we used in-gel kinase assays to determine that pp90rsk1 activated by either epidermal growth factor (EGF) or phorbol myristate acetate specifically phosphorylates Ser-167 within AF-1. In vitro kinase assays demonstrated that pp90rsk1 phosphorylates the N terminus of the wild-type ER but not of a mutant ER in which Ser-167 was replaced by Ala. In vivo, EGF stimulated phosphorylation of Ser-167 as well as Ser-118. Ectopic expression of active pp90rsk1 increased the level of phosphorylation of Ser-167 compared to that of either a mutant pp90rsk1, which is catalytically inactive in the N-terminal kinase domain, or to that of vector control. The ER formed a stable complex with the mutant pp90rsk1 in vivo. Transfection of the mutant pp90rsk1 depressed ER-dependent transcription of both a wild-type ER and a mutant ER that had a defective AF-2 domain (ER TAF-1). Furthermore, replacing either Ser-118 or Ser-167 with Ala in ER TAF-1 showed similar decreases in transcription levels. A double mutant in which both Ser-118 and Ser-167 were replaced with Ala demonstrated a further decrease in transcription compared to either of the single mutations. Taken together, our results strongly suggest that pp90rsk1 phosphorylates Ser-167 of the human ER in vivo and that Ser-167 aids in regulating the transcriptional activity of AF-1 in the ER.

* Corresponding author. Mailing address: Center for Cell Signaling, Box 577, University of Virginia, Charlottesville, VA 22908. Phone: (804) 924-1144. Fax: (804) 924-1236. E-mail: dal5f{at}virginia.edu.




This article has been cited by other articles:

  • Wong, C., Chen, S. (2009). Heat Shock Protein 90 Inhibitors: New Mode of Therapy to Overcome Endocrine Resistance. Cancer Res. 69: 8670-8677 [Abstract] [Full Text]  
  • Chen, S., Bangaru, M. L. Y., Sneade, L., Dunckley, J. A., Ben-Jonathan, N., Kansra, S. (2009). Epidermal growth factor receptor cross-talks with ligand-occupied estrogen receptor-{alpha} to modulate both lactotroph proliferation and prolactin gene expression. Am. J. Physiol. Endocrinol. Metab. 297: E331-E339 [Abstract] [Full Text]  
  • Barone, I., Cui, Y., Herynk, M. H., Corona-Rodriguez, A., Giordano, C., Selever, J., Beyer, A., Ando, S., Fuqua, S. A.W. (2009). Expression of the K303R Estrogen Receptor-{alpha} Breast Cancer Mutation Induces Resistance to an Aromatase Inhibitor via Addiction to the PI3K/Akt Kinase Pathway. Cancer Res. 69: 4724-4732 [Abstract] [Full Text]  
  • Yamnik, R. L., Digilova, A., Davis, D. C., Brodt, Z. N., Murphy, C. J., Holz, M. K. (2009). S6 Kinase 1 Regulates Estrogen Receptor {alpha} in Control of Breast Cancer Cell Proliferation. J. Biol. Chem. 284: 6361-6369 [Abstract] [Full Text]  
  • Choi, H. J., Chung, Y.-S., Kim, H. J., Moon, U. Y., Choi, Y. H., Van Seuningen, I., Baek, S. J., Yoon, H.-G., Yoon, J.-H. (2009). Signal Pathway of 17{beta}-Estradiol-Induced MUC5B Expression in Human Airway Epithelial Cells. Am. J. Respir. Cell Mol. Bio. 40: 168-178 [Abstract] [Full Text]  
  • Pancholi, S., Lykkesfeldt, A. E, Hilmi, C., Banerjee, S., Leary, A., Drury, S., Johnston, S., Dowsett, M., Martin, L.-A. (2008). ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2. Endocr Relat Cancer 15: 985-1002 [Abstract] [Full Text]  
  • Yamashita, H., Nishio, M., Toyama, T., Sugiura, H., Kondo, N., Kobayashi, S., Fujii, Y., Iwase, H. (2008). Low phosphorylation of estrogen receptor {alpha} (ER{alpha}) serine 118 and high phosphorylation of ER{alpha} serine 167 improve survival in ER-positive breast cancer. Endocr Relat Cancer 15: 755-763 [Abstract] [Full Text]  
  • Thakur, A., Sun, Y., Bollig, A., Wu, J., Biliran, H., Banerjee, S., Sarkar, F. H., Liao, D. J. (2008). Anti-invasive and Antimetastatic Activities of Ribosomal Protein S6 Kinase 4 in Breast Cancer Cells. Clin. Cancer Res. 14: 4427-4436 [Abstract] [Full Text]  
  • Thomas, R. S, Sarwar, N., Phoenix, F., Coombes, R C., Ali, S. (2008). Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-{alpha} activity. J Mol Endocrinol 40: 173-184 [Abstract] [Full Text]  
  • Lin, J.-X., Spolski, R., Leonard, W. J. (2008). Critical role for Rsk2 in T-lymphocyte activation. Blood 111: 525-533 [Abstract] [Full Text]  
  • Cheng, J., Zhang, C., Shapiro, D. J. (2007). A Functional Serine 118 Phosphorylation Site in Estrogen Receptor-{alpha} Is Required for Down-Regulation of Gene Expression by 17{beta}-Estradiol and 4-Hydroxytamoxifen. Endocrinology 148: 4634-4641 [Abstract] [Full Text]  
  • Jiang, J., Sarwar, N., Peston, D., Kulinskaya, E., Shousha, S., Coombes, R. C., Ali, S. (2007). Phosphorylation of Estrogen Receptor-{alpha} at Ser167 Is Indicative of Longer Disease-Free and Overall Survival in Breast Cancer Patients. Clin. Cancer Res. 13: 5769-5776 [Abstract] [Full Text]  
  • Ma, Y., Hu, C., Riegel, A. T., Fan, S., Rosen, E. M. (2007). Growth Factor Signaling Pathways Modulate BRCA1 Repression of Estrogen Receptor-{alpha} Activity. Mol. Endocrinol. 21: 1905-1923 [Abstract] [Full Text]  
  • Kazi, A. A., Koos, R. D. (2007). Estrogen-Induced Activation of Hypoxia-Inducible Factor-1{alpha}, Vascular Endothelial Growth Factor Expression, and Edema in the Uterus Are Mediated by the Phosphatidylinositol 3-Kinase/Akt Pathway. Endocrinology 148: 2363-2374 [Abstract] [Full Text]  
  • Sanchez, M., Sauve, K., Picard, N., Tremblay, A. (2007). The Hormonal Response of Estrogen Receptor beta Is Decreased by the Phosphatidylinositol 3-Kinase/Akt Pathway via a Phosphorylation-dependent Release of CREB-binding Protein. J. Biol. Chem. 282: 4830-4840 [Abstract] [Full Text]  
  • Vasudevan, N., Pfaff, D. W. (2007). Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles. Endocr. Rev. 28: 1-19 [Abstract] [Full Text]  
  • Fan, P., Wang, J., Santen, R. J., Yue, W. (2007). Long-term Treatment with Tamoxifen Facilitates Translocation of Estrogen Receptor {alpha} out of the Nucleus and Enhances its Interaction with EGFR in MCF-7 Breast Cancer Cells. Cancer Res. 67: 1352-1360 [Abstract] [Full Text]  
  • Likhite, V. S., Stossi, F., Kim, K., Katzenellenbogen, B. S., Katzenellenbogen, J. A. (2006). Kinase-Specific Phosphorylation of the Estrogen Receptor Changes Receptor Interactions with Ligand, Deoxyribonucleic Acid, and Coregulators Associated with Alterations in Estrogen and Tamoxifen Activity. Mol. Endocrinol. 20: 3120-3132 [Abstract] [Full Text]  
  • Zhang, S, Li, X, Burghardt, R, Smith, R III, Safe, S H (2005). Role of estrogen receptor (ER) {alpha} in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells. J Mol Endocrinol 35: 433-447 [Abstract] [Full Text]  
  • Cui, X., Schiff, R., Arpino, G., Osborne, C. K., Lee, A. V. (2005). Biology of Progesterone Receptor Loss in Breast Cancer and Its Implications for Endocrine Therapy. JCO 23: 7721-7735 [Abstract] [Full Text]  
  • Takahashi, T., Ohmichi, M., Kawagoe, J., Ohshima, C., Doshida, M., Ohta, T., Saitoh, M., Mori-Abe, A., Du, B., Igarashi, H., Takahashi, K., Kurachi, H. (2005). Growth Factors Change Nuclear Distribution of Estrogen Receptor-{alpha} via Mitogen-Activated Protein Kinase or Phosphatidylinositol 3-Kinase Cascade in a Human Breast Cancer Cell Line. Endocrinology 146: 4082-4089 [Abstract] [Full Text]  
  • Valley, C. C., Metivier, R., Solodin, N. M., Fowler, A. M., Mashek, M. T., Hill, L., Alarid, E. T. (2005). Differential Regulation of Estrogen-Inducible Proteolysis and Transcription by the Estrogen Receptor {alpha} N Terminus. Mol. Cell. Biol. 25: 5417-5428 [Abstract] [Full Text]  
  • Gburcik, V., Bot, N., Maggiolini, M., Picard, D. (2005). SPBP Is a Phosphoserine-Specific Repressor of Estrogen Receptor {alpha}. Mol. Cell. Biol. 25: 3421-3430 [Abstract] [Full Text]  
  • Clark, D.E., Errington, T.M., Smith, J.A., Frierson, H.F. Jr., Weber, M.J., Lannigan, D.A. (2005). The Serine/Threonine Protein Kinase, p90 Ribosomal S6 Kinase, Is an Important Regulator of Prostate Cancer Cell Proliferation. Cancer Res. 65: 3108-3116 [Abstract] [Full Text]  
  • Dummler, B. A., Hauge, C., Silber, J., Yntema, H. G., Kruse, L. S., Kofoed, B., Hemmings, B. A., Alessi, D. R., Frodin, M. (2005). Functional Characterization of Human RSK4, a New 90-kDa Ribosomal S6 Kinase, Reveals Constitutive Activation in Most Cell Types. J. Biol. Chem. 280: 13304-13314 [Abstract] [Full Text]  
  • Zhao, X., Lorenc, H., Stephenson, H., Wang, Y. J., Witherspoon, D., Katzenellenbogen, B., Pfaff, D., Vasudevan, N. (2005). Thyroid hormone can increase estrogen-mediated transcription from a consensus estrogen response element in neuroblastoma cells. Proc. Natl. Acad. Sci. USA 102: 4890-4895 [Abstract] [Full Text]  
  • Cho, K.-N., Choi, J. Y., Kim, C.-H., Baek, S. J., Chung, K. C., Moon, U. Y., Kim, K.-S., Lee, W.-J., Koo, J. S., Yoon, J.-H. (2005). Prostaglandin E2 Induces MUC8 Gene Expression via a Mechanism Involving ERK MAPK/RSK1/cAMP Response Element Binding Protein Activation in Human Airway Epithelial Cells. J. Biol. Chem. 280: 6676-6681 [Abstract] [Full Text]  
  • Johnston, S. R. (2005). Combinations of Endocrine and Biological Agents: Present Status of Therapeutic and Presurgical Investigations. Clin. Cancer Res. 11: 889s-899s [Abstract] [Full Text]  
  • Cui, Y., Zhang, M., Pestell, R., Curran, E. M., Welshons, W. V., Fuqua, S. A. W. (2004). Phosphorylation of Estrogen Receptor {alpha} Blocks Its Acetylation and Regulates Estrogen Sensitivity. Cancer Res. 64: 9199-9208 [Abstract] [Full Text]  
  • Ring, A., Dowsett, M. (2004). Mechanisms of tamoxifen resistance. Endocr Relat Cancer 11: 643-658 [Abstract] [Full Text]  
  • Herynk, M. H., Fuqua, S. A. W. (2004). Estrogen Receptor Mutations in Human Disease. Endocr. Rev. 25: 869-898 [Abstract] [Full Text]  
  • Edmunds, J. W., Mahadevan, L. C. (2004). MAP kinases as structural adaptors and enzymatic activators in transcription complexes. J. Cell Sci. 117: 3715-3723 [Abstract] [Full Text]  
  • Hu, Y., Fang, X., Dunham, S. M., Prada, C., Stachowiak, E. K., Stachowiak, M. K. (2004). 90-kDa Ribosomal S6 Kinase Is a Direct Target for the Nuclear Fibroblast Growth Factor Receptor 1 (FGFR1): ROLE IN FGFR1 SIGNALING. J. Biol. Chem. 279: 29325-29335 [Abstract] [Full Text]  
  • Merot, Y., Metivier, R., Penot, G., Manu, D., Saligaut, C., Gannon, F., Pakdel, F., Kah, O., Flouriot, G. (2004). The Relative Contribution Exerted by AF-1 and AF-2 Transactivation Functions in Estrogen Receptor {alpha} Transcriptional Activity Depends upon the Differentiation Stage of the Cell. J. Biol. Chem. 279: 26184-26191 [Abstract] [Full Text]  
  • Shou, J., Massarweh, S., Osborne, C. K., Wakeling, A. E., Ali, S., Weiss, H., Schiff, R. (2004). Mechanisms of Tamoxifen Resistance: Increased Estrogen Receptor-HER2/neu Cross-Talk in ER/HER2-Positive Breast Cancer. JNCI J Natl Cancer Inst 96: 926-935 [Abstract] [Full Text]  
  • Roux, P. P., Blenis, J. (2004). ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions. Microbiol. Mol. Biol. Rev. 68: 320-344 [Abstract] [Full Text]  
  • Holloway, J. N., Murthy, S., El-Ashry, D. (2004). A Cytoplasmic Substrate of Mitogen-Activated Protein Kinase Is Responsible for Estrogen Receptor-{alpha} Down-Regulation in Breast Cancer Cells: The Role of Nuclear Factor-{kappa}B. Mol. Endocrinol. 18: 1396-1410 [Abstract] [Full Text]  
  • Myers, A. P., Corson, L. B., Rossant, J., Baker, J. C. (2004). Characterization of Mouse Rsk4 as an Inhibitor of Fibroblast Growth Factor-RAS-Extracellular Signal-Regulated Kinase Signaling. Mol. Cell. Biol. 24: 4255-4266 [Abstract] [Full Text]  
  • Song, K. S., Seong, J.-K., Chung, K. C., Lee, W.-J., Kim, C.-H., Cho, K. N., Kang, C.-D., Koo, J. S., Yoon, J.-H. (2003). Induction of MUC8 Gene Expression by Interleukin-1{beta} Is Mediated by a Sequential ERK MAPK/RSK1/CREB Cascade Pathway in Human Airway Epithelial Cells. J. Biol. Chem. 278: 34890-34896 [Abstract] [Full Text]  
  • Scheper, G. C., Parra, J. L., Wilson, M., van Kollenburg, B., Vertegaal, A. C. O., Han, Z.-G., Proud, C. G. (2003). The N and C Termini of the Splice Variants of the Human Mitogen-Activated Protein Kinase-Interacting Kinase Mnk2 Determine Activity and Localization. Mol. Cell. Biol. 23: 5692-5705 [Abstract] [Full Text]  
  • Martin, L.-A., Farmer, I., Johnston, S. R. D., Ali, S., Marshall, C., Dowsett, M. (2003). Enhanced Estrogen Receptor (ER) {alpha}, ERBB2, and MAPK Signal Transduction Pathways Operate during the Adaptation of MCF-7 Cells to Long Term Estrogen Deprivation. J. Biol. Chem. 278: 30458-30468 [Abstract] [Full Text]  
  • De Bosscher, K., Vanden Berghe, W., Haegeman, G. (2003). The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression. Endocr. Rev. 24: 488-522 [Abstract] [Full Text]  
  • Kapoor, G. S., Golden, C., Atkins, B., Mehta, K. D. (2003). pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK-induced LDL receptor transcription in HepG2 cells. J. Lipid Res. 44: 584-593 [Abstract] [Full Text]  
  • Levin, E. R. (2003). Bidirectional Signaling between the Estrogen Receptor and the Epidermal Growth Factor Receptor. Mol. Endocrinol. 17: 309-317 [Abstract] [Full Text]  
  • Schiff, R., Massarweh, S., Shou, J., Osborne, C. K. (2003). Breast Cancer Endocrine Resistance: How Growth Factor Signaling and Estrogen Receptor Coregulators Modulate Response. Clin. Cancer Res. 9: 447s-454s [Abstract] [Full Text]  
  • Ahola, T. M., Alkio, N., Manninen, T., Ylikomi, T. (2002). Progestin and G Protein-Coupled Receptor 30 Inhibit Mitogen-Activated Protein Kinase Activity in MCF-7 Breast Cancer Cells. Endocrinology 143: 4620-4626 [Abstract] [Full Text]  
  • Wu, J., Janknecht, R. (2002). Regulation of the ETS Transcription Factor ER81 by the 90-kDa Ribosomal S6 Kinase 1 and Protein Kinase A. J. Biol. Chem. 277: 42669-42679 [Abstract] [Full Text]  
  • Yue, W., Wang, J.-P., Conaway, M., Masamura, S., Li, Y., Santen, R. J. (2002). Activation of the MAPK Pathway Enhances Sensitivity of MCF-7 Breast Cancer Cells to the Mitogenic Effect of Estradiol. Endocrinology 143: 3221-3229 [Abstract] [Full Text]  
  • Lee, H., Bai, W. (2002). Regulation of Estrogen Receptor Nuclear Export by Ligand-Induced and p38-Mediated Receptor Phosphorylation. Mol. Cell. Biol. 22: 5835-5845 [Abstract] [Full Text]  
  • Gioeli, D., Ficarro, S. B., Kwiek, J. J., Aaronson, D., Hancock, M., Catling, A. D., White, F. M., Christian, R. E., Settlage, R. E., Shabanowitz, J., Hunt, D. F., Weber, M. J. (2002). Androgen Receptor Phosphorylation. REGULATION AND IDENTIFICATION OF THE PHOSPHORYLATION SITES. J. Biol. Chem. 277: 29304-29314 [Abstract] [Full Text]  
  • Kraus, R. J., Ariazi, E. A., Farrell, M. L., Mertz, J. E. (2002). Estrogen-related Receptor alpha 1 Actively Antagonizes Estrogen Receptor-regulated Transcription in MCF-7 Mammary Cells. J. Biol. Chem. 277: 24826-24834 [Abstract] [Full Text]  
  • Cato, A. C. B., Nestl, A., Mink, S. (2002). Rapid Actions of Steroid Receptors in Cellular Signaling Pathways. Sci Signal 2002: re9-re9 [Abstract] [Full Text]  
  • Zhang, Y., Zhai, Q., Luo, Y., Dorf, M. E. (2002). RANTES-mediated Chemokine Transcription in Astrocytes Involves Activation and Translocation of p90 Ribosomal S6 Protein Kinase (RSK). J. Biol. Chem. 277: 19042-19048 [Abstract] [Full Text]  
  • Song, R. X.-D., McPherson, R. A., Adam, L., Bao, Y., Shupnik, M., Kumar, R., Santen, R. J. (2002). Linkage of Rapid Estrogen Action to MAPK Activation by ER{alpha}-Shc Association and Shc Pathway Activation. Mol. Endocrinol. 16: 116-127 [Abstract] [Full Text]  
  • Richards, S. A., Dreisbach, V. C., Murphy, L. O., Blenis, J. (2001). Characterization of Regulatory Events Associated with Membrane Targeting of p90 Ribosomal S6 Kinase 1. Mol. Cell. Biol. 21: 7470-7480 [Abstract] [Full Text]  
  • Nilsson, S., Makela, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M., Gustafsson, J.-A. (2001). Mechanisms of Estrogen Action. Physiol. Rev. 81: 1535-1565 [Abstract] [Full Text]  
  • Oesterreich, S., Zhang, P., Guler, R. L., Sun, X., Curran, E. M., Welshons, W. V., Osborne, C. K., Lee, A. V. (2001). Re-expression of Estrogen Receptor {alpha} in Estrogen Receptor {alpha}-negative MCF-7 Cells Restores both Estrogen and Insulin-like Growth Factor-mediated Signaling and Growth. Cancer Res. 61: 5771-5777 [Abstract] [Full Text]  
  • Sun, M., Paciga, J. E., Feldman, R. I., Yuan, Z.-q., Coppola, D., Lu, Y. Y., Shelley, S. A., Nicosia, S. V., Cheng, J. Q. (2001). Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, Activated in Breast Cancer, Regulates and Is Induced by Estrogen Receptor {alpha} (ER{alpha}) via Interaction between ER{alpha} and PI3K. Cancer Res. 61: 5985-5991 [Abstract] [Full Text]  
  • Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.-e, Karandikar, M., Berman, K., Cobb, M. H. (2001). Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions. Endocr. Rev. 22: 153-183 [Abstract] [Full Text]  
  • Clarke, R., Leonessa, F., Welch, J. N., Skaar, T. C. (2001). Cellular and Molecular Pharmacology of Antiestrogen Action and Resistance. Pharmacol. Rev. 53: 25-72 [Abstract] [Full Text]  
  • Lu, D., Giguere, V. (2001). Requirement of Ras-Dependent Pathways for Activation of the Transforming Growth Factor {beta}3 Promoter by Estradiol. Endocrinology 142: 751-759 [Abstract] [Full Text]  
  • Martin, M. B., Franke, T. F., Stoica, G. E., Chambon, P., Katzenellenbogen, B. S., Stoica, B. A., McLemore, M. S., Olivo, S. E., Stoica, A. (2000). A Role for Akt in Mediating the Estrogenic Functions of Epidermal Growth Factor and Insulin-Like Growth Factor I. Endocrinology 141: 4503-4511 [Abstract] [Full Text]  
  • Kurokawa, H., Lenferink, A. E. G., Simpson, J. F., Pisacane, P. I., Sliwkowski, M. X., Forbes, J. T., Arteaga, C. L. (2000). Inhibition of HER2/neu (erbB-2) and Mitogen-activated Protein Kinases Enhances Tamoxifen Action against HER2-overexpressing, Tamoxifen-resistant Breast Cancer Cells. Cancer Res. 60: 5887-5894 [Abstract] [Full Text]  
  • Hong, S.-H., Privalsky, M. L. (2000). The SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export. Mol. Cell. Biol. 20: 6612-6625 [Abstract] [Full Text]  
  • Bruning, J. C., Gillette, J. A., Zhao, Y., Bjorbaeck, C., Kotzka, J., Knebel, B., Avci, H., Hanstein, B., Lingohr, P., Moller, D. E., Krone, W., Kahn, C. R., Muller-Wieland, D. (2000). Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene. Proc. Natl. Acad. Sci. USA 97: 2462-2467 [Abstract] [Full Text]  
  • Giguère, V. (1999). Orphan Nuclear Receptors: From Gene to Function. Endocr. Rev. 20: 689-725 [Abstract] [Full Text]  
  • Jensen, C. J., Buch, M.-B., Krag, T. O., Hemmings, B. A., Gammeltoft, S., Frodin, M. (1999). 90-kDa Ribosomal S6 Kinase Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Protein Kinase-1. J. Biol. Chem. 274: 27168-27176 [Abstract] [Full Text]  
  • Poteet-Smith, C. E., Smith, J. A., Lannigan, D. A., Freed, T. A., Sturgill, T. W. (1999). Generation of Constitutively Active p90 Ribosomal S6 Kinase in Vivo. IMPLICATIONS FOR THE MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE FAMILY. J. Biol. Chem. 274: 22135-22138 [Abstract] [Full Text]  
  • Rogatsky, I., Trowbridge, J. M., Garabedian, M. J. (1999). Potentiation of Human Estrogen Receptor alpha Transcriptional Activation through Phosphorylation of Serines 104 and 106 by the Cyclin A-CDK2 Complex. J. Biol. Chem. 274: 22296-22302 [Abstract] [Full Text]  
  • Chen, D., Pace, P. E., Coombes, R. C., Ali, S. (1999). Phosphorylation of Human Estrogen Receptor alpha  by Protein Kinase A Regulates Dimerization. Mol. Cell. Biol. 19: 1002-1015 [Abstract] [Full Text]  
  • Smith, J. A., Poteet-Smith, C. E., Malarkey, K., Sturgill, T. W. (1999). Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo. J. Biol. Chem. 274: 2893-2898 [Abstract] [Full Text]  
  • New, L., Zhao, M., Li, Y., Bassett, W. W., Feng, Y., Ludwig, S., Padova, F. D., Gram, H., Han, J. (1999). Cloning and Characterization of RLPK, a Novel RSK-related Protein Kinase. J. Biol. Chem. 274: 1026-1032 [Abstract] [Full Text]  
  • Joel, P. B., Traish, A. M., Lannigan, D. A. (1998). Estradiol-induced Phosphorylation of Serine 118 in the Estrogen Receptor Is Independent of p42/p44 Mitogen-activated Protein Kinase. J. Biol. Chem. 273: 13317-13323 [Abstract] [Full Text]  
  • Tomas-Zuber, M., Mary, J.-L., Lesslauer, W. (2000). Control Sites of Ribosomal S6 Kinase B and Persistent Activation through Tumor Necrosis Factor. J. Biol. Chem. 275: 23549-23558 [Abstract] [Full Text]  
  • Zhang, Y., Zhong, S., Dong, Z., Chen, N., Bode, A. M., Ma, W.-y., Dong, Z. (2001). UVA Induces Ser381 Phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK Pathways. J. Biol. Chem. 276: 14572-14580 [Abstract] [Full Text]  
  • Duan, R., Xie, W., Burghardt, R. C., Safe, S. (2001). Estrogen Receptor-mediated Activation of the Serum Response Element in MCF-7 Cells through MAPK-dependent Phosphorylation of Elk-1. J. Biol. Chem. 276: 11590-11598 [Abstract] [Full Text]  
  • Tomas-Zuber, M., Mary, J.-L., Lamour, F., Bur, D., Lesslauer, W. (2001). C-terminal Elements Control Location, Activation Threshold, and p38 Docking of Ribosomal S6 Kinase B (RSKB). J. Biol. Chem. 276: 5892-5899 [Abstract] [Full Text]  
  • Smith, J. A., Poteet-Smith, C. E., Lannigan, D. A., Freed, T. A., Zoltoski, A. J., Sturgill, T. W. (2000). Creation of a Stress-activated p90 Ribosomal S6 Kinase. THE CARBOXYL-TERMINAL TAIL OF THE MAPK-ACTIVATED PROTEIN KINASES DICTATES THE SIGNAL TRANSDUCTION PATHWAY IN WHICH THEY FUNCTION. J. Biol. Chem. 275: 31588-31593 [Abstract] [Full Text]  
  • Bhatt, R. R., Ferrell, J. E. Jr. (2000). Cloning and Characterization of Xenopus Rsk2, the Predominant p90 Rsk Isozyme in Oocytes and Eggs. J. Biol. Chem. 275: 32983-32990 [Abstract] [Full Text]  
  • Kim, K.-W., Kim, S.-H., Lee, E.-Y., Kim, N. D., Kang, H.-S., Kim, H.-D., Chung, B.-S., Kang, C.-D. (2001). Extracellular Signal-regulated Kinase/90-kDa Ribosomal S6 Kinase/Nuclear Factor-kappa B Pathway Mediates Phorbol 12-Myristate 13-Acetate-induced Megakaryocytic Differentiation of K562 Cells. J. Biol. Chem. 276: 13186-13191 [Abstract] [Full Text]  
  • Campbell, R. A., Bhat-Nakshatri, P., Patel, N. M., Constantinidou, D., Ali, S., Nakshatri, H. (2001). Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor alpha . A NEW MODEL FOR ANTI-ESTROGEN RESISTANCE. J. Biol. Chem. 276: 9817-9824 [Abstract] [Full Text]  
  • Teyssier, C., Belguise, K., Galtier, F., Chalbos, D. (2001). Characterization of the Physical Interaction between Estrogen Receptor alpha and JUN Proteins. J. Biol. Chem. 276: 36361-36369 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»