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Mol Cell Biol, July 1998, p. 4109-4117, Vol. 18, No. 7
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

Mariko Takahashi-Tezuka, Yuichi Yoshida, Toshiyuki Fukada, Takuya Ohtani, Yojiro Yamanaka, Keigo Nishida, Koichi Nakajima, Masahiko Hibi, and Toshio Hirano*

Division of Molecular Oncology, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565-0871, Japan

Received 8 September 1997/Returned for modification 13 October 1997/Accepted 16 April 1998

Gab1 has structural similarities with Drosophila DOS (daughter of sevenless), which is a substrate of the protein tyrosine phosphatase Corkscrew. Both Gab1 and DOS have a pleckstrin homology domain and tyrosine residues, potential binding sites for various SH2 domain-containing adapter molecules when they are phosphorylated. We found that Gab1 was tyrosine phosphorylated in response to various cytokines, such as interleukin-6 (IL-6), IL-3, alpha interferon (IFN-alpha ), and IFN-gamma . Upon the stimulation of IL-6 or IL-3, Gab1 was found to form a complex with phosphatidylinositol (PI)-3 kinase and SHP-2, a homolog of Corkscrew. Mutational analysis of gp130, the common subunit of IL-6 family cytokine receptors, revealed that neither tyrosine residues of gp130 nor its carboxy terminus was required for tyrosine phosphorylation of Gab1. Expression of Gab1 enhanced gp130-dependent mitogen-activated protein (MAP) kinase ERK2 activation. A mutation of tyrosine 759, the SHP-2 binding site of gp130, abrogated the interactions of Gab1 with SHP-2 and PI-3 kinase as well as ERK2 activation. Furthermore, ERK2 activation was inhibited by a dominant negative p85 PI-3 kinase, wortmannin, or a dominant negative Ras. These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2, PI-3 kinase, and Ras are involved in Gab1-mediated ERK activation.

* Corresponding author. Mailing address: Division of Molecular Oncology, Biomedical Research Center, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. Phone: 81-6-879-3880. Fax: 81-6-879-3889. E-mail: hirano{at}molonc.med.osaka-u.ac.jp.

Mol Cell Biol, July 1998, p. 4109-4117, Vol. 18, No. 7
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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  • Sakkab, D., Lewitzky, M., Posern, G., Schaeper, U., Sachs, M., Birchmeier, W., Feller, S. M. (2000). Signaling of Hepatocyte Growth Factor/Scatter Factor (HGF) to the Small GTPase Rap1 via the Large Docking Protein Gab1 and the Adapter Protein CRKL. J. Biol. Chem. 275: 10772-10778 [Abstract] [Full Text]  
  • Nishigaki, K., Hanson, C., Ohashi, T., Thompson, D., Muszynski, K., Ruscetti, S. (2000). Erythroid Cells Rendered Erythropoietin Independent by Infection with Friend Spleen Focus-Forming Virus Show Constitutive Activation of Phosphatidylinositol 3-Kinase and Akt Kinase: Involvement of Insulin Receptor Substrate-Related Adapter Proteins. J. Virol. 74: 3037-3045 [Abstract] [Full Text]  
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  • Aklilu, F., Gladu, J., Goltzman, D., Rabbani, S. A. (2000). Role of Mitogen-activated Protein Kinases in the Induction of Parathyroid Hormone-related Peptide. Cancer Res. 60: 1753-1760 [Abstract] [Full Text]  
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  • Ong, S. H., Guy, G. R., Hadari, Y. R., Laks, S., Gotoh, N., Schlessinger, J., Lax, I. (2000). FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors. Mol. Cell. Biol. 20: 979-989 [Abstract] [Full Text]  
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  • Korhonen, J. M., Said, F. A., Wong, A. J., Kaplan, D. R. (1999). Gab1 Mediates Neurite Outgrowth, DNA Synthesis, and Survival in PC12 Cells. J. Biol. Chem. 274: 37307-37314 [Abstract] [Full Text]  
  • Maroun, C. R., Moscatello, D. K., Naujokas, M. A., Holgado-Madruga, M., Wong, A. J., Park, M. (1999). A Conserved Inositol Phospholipid Binding Site within the Pleckstrin Homology Domain of the Gab1 Docking Protein Is Required for Epithelial Morphogenesis. J. Biol. Chem. 274: 31719-31726 [Abstract] [Full Text]  
  • Wickrema, A., Uddin, S., Sharma, A., Chen, F., Alsayed, Y., Ahmad, S., Sawyer, S. T., Krystal, G., Yi, T., Nishada, K., Hibi, M., Hirano, T., Platanias, L. C. (1999). Engagement of Gab1 and Gab2 in Erythropoietin Signaling. J. Biol. Chem. 274: 24469-24474 [Abstract] [Full Text]  
  • Zhao, C., Yu, D.-H., Shen, R., Feng, G.-S. (1999). Gab2, a New Pleckstrin Homology Domain-containing Adapter Protein, Acts to Uncouple Signaling from ERK Kinase to Elk-1. J. Biol. Chem. 274: 19649-19654 [Abstract] [Full Text]  
  • Lecoq-Lafon, C., Verdier, F., Fichelson, S., Chretien, S., Gisselbrecht, S., Lacombe, C., Mayeux, P. (1999). Erythropoietin Induces the Tyrosine Phosphorylation of GAB1 and Its Association With SHC, SHP2, SHIP, and Phosphatidylinositol 3-Kinase. Blood 93: 2578-2585 [Abstract] [Full Text]  
  • Nishida, K., Yoshida, Y., Itoh, M., Fukada, T., Ohtani, T., Shirogane, T., Atsumi, T., Takahashi-Tezuka, M., Ishihara, K., Hibi, M., Hirano, T. (1999). Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors. Blood 93: 1809-1816 [Abstract] [Full Text]  
  • Maroun, C. R., Holgado-Madruga, M., Royal, I., Naujokas, M. A., Fournier, T. M., Wong, A. J., Park, M. (1999). The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase. Mol. Cell. Biol. 19: 1784-1799 [Abstract] [Full Text]  
  • Wang, Y., Robledo, O., Kinzie, E., Blanchard, F., Richards, C., Miyajima, A., Baumann, H. (2000). Receptor Subunit-specific Action of Oncostatin M in Hepatic Cells and Its Modulation by Leukemia Inhibitory Factor. J. Biol. Chem. 275: 25273-25285 [Abstract] [Full Text]  
  • Lock, L. S., Royal, I., Naujokas, M. A., Park, M. (2000). Identification of an Atypical Grb2 Carboxyl-terminal SH3 Domain Binding Site in Gab Docking Proteins Reveals Grb2-dependent and -independent Recruitment of Gab1 to Receptor Tyrosine Kinases. J. Biol. Chem. 275: 31536-31545 [Abstract] [Full Text]  
  • Ali, S., Ali, S. (2000). Recruitment of the Protein-tyrosine Phosphatase SHP-2 to the C-terminal Tyrosine of the Prolactin Receptor and to the Adaptor Protein Gab2. J. Biol. Chem. 275: 39073-39080 [Abstract] [Full Text]  
  • Craddock, B. L., Hobbs, J., Edmead, C. E., Welham, M. J. (2001). Phosphoinositide 3-Kinase-dependent Regulation of Interleukin-3-induced Proliferation. INVOLVEMENT OF MITOGEN-ACTIVATED PROTEIN KINASES, SHP2 AND Gab2. J. Biol. Chem. 276: 24274-24283 [Abstract] [Full Text]  
  • Cunnick, J. M., Mei, L., Doupnik, C. A., Wu, J. (2001). Phosphotyrosines 627 and 659 of Gab1 Constitute a Bisphosphoryl Tyrosine-based Activation Motif (BTAM) Conferring Binding and Activation of SHP2. J. Biol. Chem. 276: 24380-24387 [Abstract] [Full Text]  
  • Ingham, R. J., Santos, L., Dang-Lawson, M., Holgado-Madruga, M., Dudek, P., Maroun, C. R., Wong, A. J., Matsuuchi, L., Gold, M. R. (2001). The Gab1 Docking Protein Links the B Cell Antigen Receptor to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and to the SHP2 Tyrosine Phosphatase. J. Biol. Chem. 276: 12257-12265 [Abstract] [Full Text]  
  • Uozumi, H., Hiroi, Y., Zou, Y., Takimoto, E., Toko, H., Niu, P., Shimoyama, M., Yazaki, Y., Nagai, R., Komuro, I. (2001). gp130 Plays a Critical Role in Pressure Overload-induced Cardiac Hypertrophy. J. Biol. Chem. 276: 23115-23119 [Abstract] [Full Text]  
  • Shinohara, M., Kodama, A., Matozaki, T., Fukuhara, A., Tachibana, K., Nakanishi, H., Takai, Y. (2001). Roles of Cell-Cell Adhesion-dependent Tyrosine Phosphorylation of Gab-1. J. Biol. Chem. 276: 18941-18946 [Abstract] [Full Text]  
  • Lelievre, E., Plun-Favreau, H., Chevalier, S., Froger, J., Guillet, C., Elson, G. C. A., Gauchat, J.-F., Gascan, H. (2001). Signaling Pathways Recruited by the Cardiotrophin-like Cytokine/Cytokine-like Factor-1 Composite Cytokine. SPECIFIC REQUIREMENT OF THE MEMBRANE-BOUND FORM OF CILIARY NEUROTROPHIC FACTOR RECEPTOR alpha COMPONENT. J. Biol. Chem. 276: 22476-22484 [Abstract] [Full Text]  
  • Yamasaki, S., Nishida, K., Hibi, M., Sakuma, M., Shiina, R., Takeuchi, A., Ohnishi, H., Hirano, T., Saito, T. (2001). Docking Protein Gab2 Is Phosphorylated by ZAP-70 and Negatively Regulates T Cell Receptor Signaling by Recruitment of Inhibitory Molecules. J. Biol. Chem. 276: 45175-45183 [Abstract] [Full Text]  
  • Senga, T., Iwamoto, T., Kitamura, T., Miyake, Y., Hamaguchi, M. (2001). JAK/STAT3-dependent Activation of the RalGDS/Ral Pathway in M1 Mouse Myeloid Leukemia Cells. J. Biol. Chem. 276: 32678-32681 [Abstract] [Full Text]  
  • Rojnuckarin, P., Miyakawa, Y., Fox, N. E., Deou, J., Daum, G., Kaushansky, K. (2001). The Roles of Phosphatidylinositol 3-Kinase and Protein Kinase Czeta for Thrombopoietin-induced Mitogen-activated Protein Kinase Activation in Primary Murine Megakaryocytes. J. Biol. Chem. 276: 41014-41022 [Abstract] [Full Text]  


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