This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harrod, R.
Right arrow Articles by Giam, C.-Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harrod, R.
Right arrow Articles by Giam, C.-Z.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, September 1998, p. 5052-5061, Vol. 18, No. 9
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

An Exposed KID-Like Domain in Human T-Cell Lymphotropic Virus Type 1 Tax Is Responsible for the Recruitment of Coactivators CBP/p300

Robert Harrod,1 Yong Tang,1 Christophe Nicot,1 Hsieng S. Lu,2 Alex Vassilev,3 Yoshihiro Nakatani,3 and Chou-Zen Giam1,*

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 208141; Department of Protein Structure, Amgen Inc., Thousand Oaks, California 913202; and Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-27533

Received 7 April 1998/Returned for modification 18 May 1998/Accepted 9 June 1998

Human T-cell lymphotropic virus type 1 (HTLV-1) transcriptional activation is mediated by the viral transactivator, Tax, and three 21-bp repeats (Tax response element [TxRE]) located in the U3 region of the viral long terminal repeat (LTR). Each TxRE contains a core cyclic AMP response element (CRE) flanked by 5' G-rich and 3' C-rich sequences. The TxRE binds CREB (CRE-binding protein) and Tax to form a ternary complex and confers Tax-dependent transactivation. Recent data indicate that Tax functions as a specific link to connect CREB-binding protein (CBP)/p300 in a phosphorylation-independent manner to CREB/ATF-1 assembled on the viral 21-bp repeats. Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization. Amino acid residues around the trypsin- and chymotrypsin-sensitive sites (88KVL90) of Tax bear resemblance to those in the kinase-inducible domain of CREB (129SRRPSYRKILNE140) surrounding Ser-133, which undergoes signal-induced phosphorylation to recruit CBP/p300. Site-directed mutagenesis of residues in this domain (R82A, K85A, K88A, and V89A) resulted in proteins which failed to transactivate from the HTLV-1 LTR in vivo. These mutants (K85A, K88A, and V89A) bind CREB with similar affinities as wild-type Tax, yet interaction with CBP/p300 is abrogated in various biochemical assays, indicating that the recruitment of CBP/p300 is crucial for Tax transactivation. A Tax mutant, M47, defective in the COOH-terminal transactivation domain, continued to interact with CBP/p300, suggesting that interactions with additional cellular factors are required for proper Tax function.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814. Phone: (301) 295-9624. Fax: (301) 295-1545. E-mail: giam{at}bob.usuf2.usuhs.mil.

Molecular and Cellular Biology, September 1998, p. 5052-5061, Vol. 18, No. 9
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Nejmeddine, M., Negi, V. S., Mukherjee, S., Tanaka, Y., Orth, K., Taylor, G. P., Bangham, C. R. M. (2009). HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse. Blood 114: 1016-1025 [Abstract] [Full Text]  
  • Landry, S., Halin, M., Vargas, A., Lemasson, I., Mesnard, J.-M., Barbeau, B. (2009). Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein. J. Virol. 83: 2048-2054 [Abstract] [Full Text]  
  • Fukuda, R.-i., Tsuchiya, K., Suzuki, K., Itoh, K., Fujita, J., Utsunomiya, A., Tsuji, T. (2009). Human T-cell Leukemia Virus Type I Tax Down-regulates the Expression of Phosphatidylinositol 3,4,5-Trisphosphate Inositol Phosphatases via the NF-{kappa}B Pathway. J. Biol. Chem. 284: 2680-2689 [Abstract] [Full Text]  
  • Clerc, I., Polakowski, N., Andre-Arpin, C., Cook, P., Barbeau, B., Mesnard, J.-M., Lemasson, I. (2008). An Interaction between the Human T Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) and the KIX Domain of p300/CBP Contributes to the Down-regulation of Tax-dependent Viral Transcription by HBZ. J. Biol. Chem. 283: 23903-23913 [Abstract] [Full Text]  
  • Geiger, T. R., Sharma, N., Kim, Y.-M., Nyborg, J. K. (2008). The Human T-Cell Leukemia Virus Type 1 Tax Protein Confers CBP/p300 Recruitment and Transcriptional Activation Properties to Phosphorylated CREB. Mol. Cell. Biol. 28: 1383-1392 [Abstract] [Full Text]  
  • Cho, W.-K., Zhou, M., Jang, M. K., Huang, K., Jeong, S.-J., Ozato, K., Brady, J. N. (2007). Modulation of the Brd4/P-TEFb Interaction by the Human T-Lymphotropic Virus Type 1 Tax Protein. J. Virol. 81: 11179-11186 [Abstract] [Full Text]  
  • Hishiki, T., Ohshima, T., Ego, T., Shimotohno, K. (2007). BCL3 Acts as a Negative Regulator of Transcription from the Human T-cell Leukemia Virus Type 1 Long Terminal Repeat through Interactions with TORC3. J. Biol. Chem. 282: 28335-28343 [Abstract] [Full Text]  
  • Kim, Y.-M., Ramirez, J. A., Mick, J. E., Giebler, H. A., Yan, J.-P., Nyborg, J. K. (2007). Molecular Characterization of the Tax-containing HTLV-1 Enhancer Complex Reveals a Prominent Role for CREB Phosphorylation in Tax Transactivation. J. Biol. Chem. 282: 18750-18757 [Abstract] [Full Text]  
  • Sinha-Datta, U., Datta, A., Ghorbel, S., Dodon, M. D., Nicot, C. (2007). Human T-cell Lymphotrophic Virus Type I Rex and p30 Interactions Govern the Switch between Virus Latency and Replication. J. Biol. Chem. 282: 14608-14615 [Abstract] [Full Text]  
  • Lemasson, I., Lewis, M. R., Polakowski, N., Hivin, P., Cavanagh, M.-H., Thebault, S., Barbeau, B., Nyborg, J. K., Mesnard, J.-M. (2007). Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription. J. Virol. 81: 1543-1553 [Abstract] [Full Text]  
  • Twizere, J.-C., Springael, J.-Y., Boxus, M., Burny, A., Dequiedt, F., Dewulf, J.-F., Duchateau, J., Portetelle, D., Urbain, P., Lint, C. V., Green, P. L., Mahieux, R., Parmentier, M., Willems, L., Kettmann, R. (2007). Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling. Blood 109: 1051-1060 [Abstract] [Full Text]  
  • Wencker, M., Sausse, C., Derse, D., Gazzolo, L., Duc Dodon, M. (2007). Human T-Cell Leukemia Virus Type 1 Tax Protein Down-Regulates Pre-T-Cell Receptor Alpha Gene Transcription in Human Immature Thymocytes. J. Virol. 81: 301-308 [Abstract] [Full Text]  
  • Tomita, M., Kikuchi, A., Akiyama, T., Tanaka, Y., Mori, N. (2006). Human T-Cell Leukemia Virus Type 1 Tax Dysregulates {beta}-Catenin Signaling. J. Virol. 80: 10497-10505 [Abstract] [Full Text]  
  • Durkin, S. S., Ward, M. D., Fryrear, K. A., Semmes, O. J. (2006). Site-specific Phosphorylation Differentiates Active from Inactive Forms of the Human T-cell Leukemia Virus Type 1 Tax Oncoprotein. J. Biol. Chem. 281: 31705-31712 [Abstract] [Full Text]  
  • Calattini, S., Chevalier, S. A., Duprez, R., Afonso, P., Froment, A., Gessain, A., Mahieux, R. (2006). Human T-Cell Lymphotropic Virus Type 3: Complete Nucleotide Sequence and Characterization of the Human Tax3 Protein. J. Virol. 80: 9876-9888 [Abstract] [Full Text]  
  • Jeong, S.-J., Lu, H., Cho, W.-K., Park, H. U., Pise-Masison, C., Brady, J. N. (2006). Coactivator-Associated Arginine Methyltransferase 1 Enhances Transcriptional Activity of the Human T-Cell Lymphotropic Virus Type 1 Long Terminal Repeat through Direct Interaction with Tax.. J. Virol. 80: 10036-10044 [Abstract] [Full Text]  
  • Tosi, G., Pilotti, E., Mortara, L., Barbaro, A. D. L., Casoli, C., Accolla, R. S. (2006). Inhibition of human T cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y. Proc. Natl. Acad. Sci. USA 103: 12861-12866 [Abstract] [Full Text]  
  • Zhang, L., Liu, M., Merling, R., Giam, C.-Z. (2006). Versatile Reporter Systems Show that Transactivation by Human T-Cell Leukemia Virus Type 1 Tax Occurs Independently of Chromatin Remodeling Factor BRG1.. J. Virol. 80: 7459-7468 [Abstract] [Full Text]  
  • Siu, Y.-T., Chin, K.-T., Siu, K.-L., Yee Wai Choy, E., Jeang, K.-T., Jin, D.-Y. (2006). TORC1 and TORC2 Coactivators Are Required for Tax Activation of the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeats. J. Virol. 80: 7052-7059 [Abstract] [Full Text]  
  • Waldele, K., Silbermann, K., Schneider, G., Ruckes, T., Cullen, B. R., Grassmann, R. (2006). Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes. Blood 107: 4491-4499 [Abstract] [Full Text]  
  • Nasr, R., Chiari, E., El-Sabban, M., Mahieux, R., Kfoury, Y., Abdulhay, M., Yazbeck, V., Hermine, O., de The, H., Pique, C., Bazarbachi, A. (2006). Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-{kappa}B activation. Blood 107: 4021-4029 [Abstract] [Full Text]  
  • Lemasson, I., Polakowski, N. J., Laybourn, P. J., Nyborg, J. K. (2006). Tax-dependent Displacement of Nucleosomes during Transcriptional Activation of Human T-Cell Leukemia Virus Type 1. J. Biol. Chem. 281: 13075-13082 [Abstract] [Full Text]  
  • Awasthi, S., Sharma, A., Wong, K., Zhang, J., Matlock, E. F., Rogers, L., Motloch, P., Takemoto, S., Taguchi, H., Cole, M. D., Luscher, B., Dittrich, O., Tagami, H., Nakatani, Y., McGee, M., Girard, A.-M., Gaughan, L., Robson, C. N., Monnat, R. J. Jr., Harrod, R. (2005). A Human T-Cell Lymphotropic Virus Type 1 Enhancer of Myc Transforming Potential Stabilizes Myc-TIP60 Transcriptional Interactions. Mol. Cell. Biol. 25: 6178-6198 [Abstract] [Full Text]  
  • Wong, K., Zhang, J., Awasthi, S., Sharma, A., Rogers, L., Matlock, E. F., Van Lint, C., Karpova, T., McNally, J., Harrod, R. (2004). Nerve Growth Factor Receptor Signaling Induces Histone Acetyltransferase Domain-dependent Nuclear Translocation of p300/CREB-binding Protein-associated Factor and hGCN5 Acetyltransferases. J. Biol. Chem. 279: 55667-55674 [Abstract] [Full Text]  
  • Koga, H., Ohshima, T., Shimotohno, K. (2004). Enhanced Activation of Tax-dependent Transcription of Human T-cell Leukemia Virus Type I (HTLV-I) Long Terminal Repeat by TORC3. J. Biol. Chem. 279: 52978-52983 [Abstract] [Full Text]  
  • Meertens, L., Chevalier, S., Weil, R., Gessain, A., Mahieux, R. (2004). A 10-Amino Acid Domain within Human T-cell Leukemia Virus Type 1 and Type 2 Tax Protein Sequences Is Responsible for Their Divergent Subcellular Distribution. J. Biol. Chem. 279: 43307-43320 [Abstract] [Full Text]  
  • Lu, H., Pise-Masison, C. A., Linton, R., Park, H. U., Schiltz, R. L., Sartorelli, V., Brady, J. N. (2004). Tax Relieves Transcriptional Repression by Promoting Histone Deacetylase 1 Release from the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat. J. Virol. 78: 6735-6743 [Abstract] [Full Text]  
  • Waldele, K., Schneider, G., Ruckes, T., Grassmann, R. (2004). Interleukin-13 Overexpression by Tax Transactivation: a Potential Autocrine Stimulus in Human T-Cell Leukemia Virus-Infected Lymphocytes. J. Virol. 78: 6081-6090 [Abstract] [Full Text]  
  • Livengood, J. A., Nyborg, J. K. (2004). The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expression. Nucleic Acids Res 32: 2829-2837 [Abstract] [Full Text]  
  • Casoli, C., De Lerma Barbaro, A., Pilotti, E., Bertazzoni, U., Tosi, G., Accolla, R. S. (2004). The MHC class II transcriptional activator (CIITA) inhibits HTLV-2 viral replication by blocking the function of the viral transactivator Tax-2. Blood 103: 995-1001 [Abstract] [Full Text]  
  • Wu, K., Bottazzi, M. E., de la Fuente, C., Deng, L., Gitlin, S. D., Maddukuri, A., Dadgar, S., Li, H., Vertes, A., Pumfery, A., Kashanchi, F. (2004). Protein Profile of Tax-associated Complexes. J. Biol. Chem. 279: 495-508 [Abstract] [Full Text]  
  • Basbous, J., Bazarbachi, A., Granier, C., Devaux, C., Mesnard, J.-M. (2003). The Central Region of Human T-Cell Leukemia Virus Type 1 Tax Protein Contains Distinct Domains Involved in Subunit Dimerization. J. Virol. 77: 13028-13035 [Abstract] [Full Text]  
  • Georges, S. A., Giebler, H. A., Cole, P. A., Luger, K., Laybourn, P. J., Nyborg, J. K. (2003). Tax Recruitment of CBP/p300, via the KIX Domain, Reveals a Potent Requirement for Acetyltransferase Activity That Is Chromatin Dependent and Histone Tail Independent. Mol. Cell. Biol. 23: 3392-3404 [Abstract] [Full Text]  
  • Hiraiwa, N., Yabuta, T., Yoritomi, K., Hiraiwa, M., Tanaka, Y., Suzuki, T., Yoshida, M., Kannagi, R. (2003). Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element. Blood 101: 3615-3621 [Abstract] [Full Text]  
  • Lemasson, I., Polakowski, N. J., Laybourn, P. J., Nyborg, J. K. (2002). Transcription Factor Binding and Histone Modifications on the Integrated Proviral Promoter in Human T-cell Leukemia Virus-I-infected T-cells. J. Biol. Chem. 277: 49459-49465 [Abstract] [Full Text]  
  • Arnulf, B., Villemain, A., Nicot, C., Mordelet, E., Charneau, P., Kersual, J., Zermati, Y., Mauviel, A., Bazarbachi, A., Hermine, O. (2002). Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood 100: 4129-4138 [Abstract] [Full Text]  
  • Goto, N. K., Zor, T., Martinez-Yamout, M., Dyson, H. J., Wright, P. E. (2002). Cooperativity in Transcription Factor Binding to the Coactivator CREB-binding Protein (CBP). THE MIXED LINEAGE LEUKEMIA PROTEIN (MLL) ACTIVATION DOMAIN BINDS TO AN ALLOSTERIC SITE ON THE KIX DOMAIN. J. Biol. Chem. 277: 43168-43174 [Abstract] [Full Text]  
  • Lee, D. K., Kim, B.-C., Brady, J. N., Jeang, K.-T., Kim, S.-J. (2002). Human T-cell Lymphotropic Virus Type 1 Tax Inhibits Transforming Growth Factor-beta Signaling by Blocking the Association of Smad Proteins with Smad-binding Element. J. Biol. Chem. 277: 33766-33775 [Abstract] [Full Text]  
  • Lu, H., Pise-Masison, C. A., Fletcher, T. M., Schiltz, R. L., Nagaich, A. K., Radonovich, M., Hager, G., Cole, P. A., Brady, J. N. (2002). Acetylation of Nucleosomal Histones by p300 Facilitates Transcription from Tax-Responsive Human T-Cell Leukemia Virus Type 1 Chromatin Template. Mol. Cell. Biol. 22: 4450-4462 [Abstract] [Full Text]  
  • Liang, M.-H., Geisbert, T., Yao, Y., Hinrichs, S. H., Giam, C.-Z. (2002). Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes S-Phase Entry but Blocks Mitosis. J. Virol. 76: 4022-4033 [Abstract] [Full Text]  
  • Georges, S. A., Kraus, W. L., Luger, K., Nyborg, J. K., Laybourn, P. J. (2002). p300-Mediated Tax Transactivation from Recombinant Chromatin: Histone Tail Deletion Mimics Coactivator Function. Mol. Cell. Biol. 22: 127-137 [Abstract] [Full Text]  
  • Zhang, W., Nisbet, J. W., Albrecht, B., Ding, W., Kashanchi, F., Bartoe, J. T., Lairmore, M. D. (2001). Human T-Lymphotropic Virus Type 1 p30II Regulates Gene Transcription by Binding CREB Binding Protein/p300. J. Virol. 75: 9885-9895 [Abstract] [Full Text]  
  • Scoggin, K. E. S., Ulloa, A., Nyborg, J. K. (2001). The Oncoprotein Tax Binds the SRC-1-Interacting Domain of CBP/p300 To Mediate Transcriptional Activation. Mol. Cell. Biol. 21: 5520-5530 [Abstract] [Full Text]  
  • Ernst, P., Wang, J., Huang, M., Goodman, R. H., Korsmeyer, S. J. (2001). MLL and CREB Bind Cooperatively to the Nuclear Coactivator CREB-Binding Protein. Mol. Cell. Biol. 21: 2249-2258 [Abstract] [Full Text]  
  • Mori, N., Morishita, M., Tsukazaki, T., Giam, C.-Z., Kumatori, A., Tanaka, Y., Yamamoto, N. (2001). Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor {beta} signaling through interaction with CREB-binding protein/p300. Blood 97: 2137-2144 [Abstract] [Full Text]  
  • Kibler, K. V., Jeang, K.-T. (2001). CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein. J. Virol. 75: 2161-2173 [Abstract] [Full Text]  
  • Van, P. L., Yim, K.-W., Jin, D.-Y., Dapolito, G., Kurimasa, A., Jeang, K.-T. (2001). Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53. J. Virol. 75: 396-407 [Abstract] [Full Text]  
  • Robek, M. D., Ratner, L. (2000). Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction. J. Virol. 74: 11988-11992 [Abstract] [Full Text]  
  • Shuh, M., Derse, D. (2000). Ternary Complex Factors and Cofactors Are Essential for Human T-Cell Leukemia Virus Type 1 Tax Transactivation of the Serum Response Element. J. Virol. 74: 11394-11397 [Abstract] [Full Text]  
  • Nicot, C., Harrod, R. (2000). Distinct p300-Responsive Mechanisms Promote Caspase-Dependent Apoptosis by Human T-Cell Lymphotropic Virus Type 1 Tax Protein. Mol. Cell. Biol. 20: 8580-8589 [Abstract] [Full Text]  
  • Giebler, H. A., Lemasson, I., Nyborg, J. K. (2000). p53 Recruitment of CREB Binding Protein Mediated through Phosphorylated CREB: a Novel Pathway of Tumor Suppressor Regulation. Mol. Cell. Biol. 20: 4849-4858 [Abstract] [Full Text]  
  • Goodman, R. H., Smolik, S. (2000). CBP/p300 in cell growth, transformation, and development. Genes Dev. 14: 1553-1577 [Full Text]  
  • Pise-Masison, C. A., Mahieux, R., Jiang, H., Ashcroft, M., Radonovich, M., Duvall, J., Guillerm, C., Brady, J. N. (2000). Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-kappa B Pathway and Is Dependent on p53 Phosphorylation. Mol. Cell. Biol. 20: 3377-3386 [Abstract] [Full Text]  
  • Gachon, F., Thebault, S., Peleraux, A., Devaux, C., Mesnard, J.-M. (2000). Molecular Interactions Involved in the Transactivation of the Human T-Cell Leukemia Virus Type 1 Promoter Mediated by Tax and CREB-2 (ATF-4). Mol. Cell. Biol. 20: 3470-3481 [Abstract] [Full Text]  
  • Harrod, R., Kuo, Y.-L., Tang, Y., Yao, Y., Vassilev, A., Nakatani, Y., Giam, C.-Z. (2000). p300 and p300/cAMP-responsive Element-binding Protein Associated Factor Interact with Human T-cell Lymphotropic Virus Type-1 Tax in a Multi-histone Acetyltransferase/Activator-Enhancer Complex. J. Biol. Chem. 275: 11852-11857 [Abstract] [Full Text]  
  • Burton, M., Upadhyaya, C. D., Maier, B., Hope, T. J., Semmes, O. J. (2000). Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets. J. Virol. 74: 2351-2364 [Abstract] [Full Text]  
  • Jiang, H., Lu, H., Schiltz, R. L., Pise-Masison, C. A., Ogryzko, V. V., Nakatani, Y., Brady, J. N. (1999). PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner. Mol. Cell. Biol. 19: 8136-8145 [Abstract] [Full Text]  
  • Kimzey, A. L., Dynan, W. S. (1999). Identification of a Human T-cell Leukemia Virus Type I Tax Peptide in Contact with DNA. J. Biol. Chem. 274: 34226-34232 [Abstract] [Full Text]  
  • Van Orden, K., Giebler, H. A., Lemasson, I., Gonzales, M., Nyborg, J. K. (1999). Binding of p53 to the KIX Domain of CREB Binding Protein. A POTENTIAL LINK TO HUMAN T-CELL LEUKEMIA VIRUS, TYPE I-ASSOCIATED LEUKEMOGENESIS. J. Biol. Chem. 274: 26321-26328 [Abstract] [Full Text]  
  • Robek, M. D., Ratner, L. (1999). Immortalization of CD4+ and CD8+ T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone. J. Virol. 73: 4856-4865 [Abstract] [Full Text]  
  • Xiao, G., Harhaj, E. W., Sun, S.-C. (2000). Domain-specific Interaction with the Ikappa B Kinase (IKK) Regulatory Subunit IKKgamma Is an Essential Step in Tax-mediated Activation of IKK. J. Biol. Chem. 275: 34060-34067 [Abstract] [Full Text]  
  • Pise-Masison, C. A., Mahieux, R., Radonovich, M., Jiang, H., Brady, J. N. (2001). Human T-lymphotropic Virus Type I Tax Protein Utilizes Distinct Pathways for p53 Inhibition That Are Cell Type-dependent. J. Biol. Chem. 276: 200-205 [Abstract] [Full Text]  
  • Lemasson, I., Nyborg, J. K. (2001). Human T-cell Leukemia Virus Type I Tax Repression of p73beta Is Mediated through Competition for the C/H1 Domain of CBP. J. Biol. Chem. 276: 15720-15727 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»