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Molecular and Cellular Biology, October 1999, p. 7203-7215, Vol. 19, No. 10
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis

Francesca Peruzzi, Marco Prisco, Michael Dews, Paolo Salomoni, Emanuela Grassilli, Gaetano Romano, Bruno Calabretta, and Renato Baserga*

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Received 3 March 1999/Returned for modification 27 April 1999/Accepted 15 July 1999

The type 1 insulin-like growth factor receptor (IGF-1R), activated by its ligands, protects several cell types from a variety of apoptotic injuries. The main signaling pathway for IGF-1R-mediated protection from apoptosis has been previously elucidated and rests on the activation of phosphatidylinositol 3-kinase, Akt/protein kinase B, and the phosphorylation and inactivation of BAD, a member of the Bcl-2 family of proteins. In 32D cells (a murine hemopoietic cell line devoid of insulin receptor substrate 1 [IRS-1]), the IGF-1R activates alternative pathways for protection from apoptosis induced by withdrawal of interleukin-3. One of these pathways leads to the activation of mitogen-activated protein kinase, while a third pathway results in the mitochondrial translocation of Raf and depends on the integrity of a group of serines in the C terminus of the receptor that are known to interact with 14.3.3 proteins. All three pathways, however, result in BAD phosphorylation. The presence of multiple antiapoptotic pathways may explain the remarkable efficacy of the IGF-1R in protecting cells from apoptosis.

* Corresponding author. Mailing address: Kimmel Cancer Center, Thomas Jefferson University, 624 Bluemle Life Sciences Building, 233 S. 10th St., Philadelphia, PA 19107. Phone: (215) 503-4507. Fax: (215) 923-0249. E-mail: r_baserga{at}lac.jci.tju.edu.

Molecular and Cellular Biology, October 1999, p. 7203-7215, Vol. 19, No. 10
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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  • Prisco, M., Peruzzi, F., Belletti, B., Baserga, R. (2001). Regulation of Id Gene Expression by Type I Insulin-Like Growth Factor: Roles of STAT3 and the Tyrosine 950 Residue of the Receptor. Mol. Cell. Biol. 21: 5447-5458 [Abstract] [Full Text]  
  • Kim, J. J., Park, B.-C., Kido, Y., Accili, D. (2001). Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes. Endocrinology 142: 3354-3360 [Abstract] [Full Text]  
  • Nickerson, T., Chang, F., Lorimer, D., Smeekens, S. P., Sawyers, C. L., Pollak, M. (2001). In Vivo Progression of LAPC-9 and LNCaP Prostate Cancer Models to Androgen Independence Is Associated with Increased Expression of Insulin-like Growth Factor I (IGF-I) and IGF-I Receptor (IGF-IR). Cancer Res. 61: 6276-6280 [Abstract] [Full Text]  
  • Harada, H., Andersen, J. S., Mann, M., Terada, N., Korsmeyer, S. J. (2001). p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc. Natl. Acad. Sci. USA 10.1073/pnas.171301998v1 [Abstract] [Full Text]  
  • Beery, R., Haimsohn, M., Wertheim, N., Hemi, R., Nir, U., Karasik, A., Kanety, H., Geier, A. (2001). Activation of the Insulin-Like Growth Factor 1 Signaling Pathway by the Antiapoptotic Agents Aurintricarboxylic Acid and Evans Blue. Endocrinology 142: 3098-3107 [Abstract] [Full Text]  
  • Valentinis, B, Baserga, R (2001). IGF-I receptor signalling in transformation and differentiation. Mol. Pathol. 54: 133-137 [Abstract] [Full Text]  
  • Navarro, M., Baserga, R. (2001). Limited Redundancy of Survival Signals from the Type 1 Insulin-Like Growth Factor Receptor. Endocrinology 142: 1073-1081 [Abstract] [Full Text]  
  • Chiang, C.-W., Harris, G., Ellig, C., Masters, S. C., Subramanian, R., Shenolikar, S., Wadzinski, B. E., Yang, E. (2001). Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. Blood 97: 1289-1297 [Abstract] [Full Text]  
  • Peretz, S., Jensen, R., Baserga, R., Glazer, P. M. (2001). ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc. Natl. Acad. Sci. USA 10.1073/pnas.041416598v1 [Abstract] [Full Text]  
  • Gagnon, A., Dods, P., Roustan-Delatour, N., Chen, C.-S., Sorisky, A. (2001). Phosphatidylinositol-3,4,5-Trisphosphate Is Required for Insulin-Like Growth Factor 1-Mediated Survival of 3T3-L1 Preadipocytes. Endocrinology 142: 205-212 [Abstract] [Full Text]  
  • Gerhardinger, C., McClure, K. D., Romeo, G., Podestà, F., Lorenzi, M. (2001). IGF-I mRNA and Signaling in the Diabetic Retina. Diabetes 50: 175-183 [Abstract] [Full Text]  
  • Playford, M. P., Bicknell, D., Bodmer, W. F., Macaulay, V. M. (2000). Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta -catenin. Proc. Natl. Acad. Sci. USA 10.1073/pnas.210394297v1 [Abstract] [Full Text]  
  • Jung, F., Haendeler, J., Goebel, C., Zeiher, A. M., Dimmeler, S. (2000). Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death. Cardiovasc Res 48: 148-157 [Abstract] [Full Text]  
  • Dews, M., Prisco, M., Peruzzi, F., Romano, G., Morrione, A., Baserga, R. (2000). Domains of the Insulin-Like Growth Factor I Receptor Required for the Activation of Extracellular Signal-Regulated Kinases. Endocrinology 141: 1289-1300 [Abstract] [Full Text]  
  • Morrione, A., Romano, G., Navarro, M., Reiss, K., Valentinis, B., Dews, M., Eves, E., Rosner, M. R., Baserga, R. (2000). Insulin-like Growth Factor I Receptor Signaling in Differentiation of Neuronal H19-7 Cells. Cancer Res. 60: 2263-2272 [Abstract] [Full Text]  
  • Valentinis, B., Navarro, M., Zanocco-Marani, T., Edmonds, P., McCormick, J., Morrione, A., Sacchi, A., Romano, G., Reiss, K., Baserga, R. (2000). Insulin Receptor Substrate-1, p70S6K, and Cell Size in Transformation and Differentiation of Hemopoietic Cells. J. Biol. Chem. 275: 25451-25459 [Abstract] [Full Text]  
  • Krause, D., Lyons, A., Fennelly, C., O'Connor, R. (2001). Transient Activation of Jun N-terminal Kinases and Protection from Apoptosis by the Insulin-like Growth Factor I Receptor Can Be Suppressed by Dicumarol. J. Biol. Chem. 276: 19244-19252 [Abstract] [Full Text]  
  • Belletti, B., Prisco, M., Morrione, A., Valentinis, B., Navarro, M., Baserga, R. (2001). Regulation of Id2 Gene Expression by the Insulin-like Growth Factor I Receptor Requires Signaling by Phosphatidylinositol 3-Kinase. J. Biol. Chem. 276: 13867-13874 [Abstract] [Full Text]  
  • Khatib, A.-M., Siegfried, G., Prat, A., Luis, J., Chretien, M., Metrakos, P., Seidah, N. G. (2001). Inhibition of Proprotein Convertases Is Associated with Loss of Growth and Tumorigenicity of HT-29 Human Colon Carcinoma Cells. IMPORTANCE OF INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) RECEPTOR PROCESSING IN IGF-1-MEDIATED FUNCTIONS. J. Biol. Chem. 276: 30686-30693 [Abstract] [Full Text]  
  • Peruzzi, F., Prisco, M., Morrione, A., Valentinis, B., Baserga, R. (2001). Anti-apoptotic Signaling of the Insulin-like Growth Factor-I Receptor through Mitochondrial Translocation of c-Raf and Nedd4. J. Biol. Chem. 276: 25990-25996 [Abstract] [Full Text]  
  • Bieberich, E., MacKinnon, S., Silva, J., Yu, R. K. (2001). Regulation of Apoptosis during Neuronal Differentiation by Ceramide and b-Series Complex Gangliosides. J. Biol. Chem. 276: 44396-44404 [Abstract] [Full Text]  
  • Peretz, S., Jensen, R., Baserga, R., Glazer, P. M. (2001). ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc. Natl. Acad. Sci. USA 98: 1676-1681 [Abstract] [Full Text]  


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