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Molecular and Cellular Biology, October 1999, p. 7237-7244, Vol. 19, No. 10
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Targeted Disruption of Mouse Yin Yang 1 Transcription Factor Results in Peri-Implantation Lethality

Mary E. Donohoe,1 Xiaolin Zhang,1 Lynda McGinnis,2 John Biggers,2 En Li,3 and Yang Shi1,*

Department of Pathology1 and Department of Cell Biology,2 Harvard Medical School, Boston, Massachusetts 02115, and Cardiovascular Research Center, Massachusetts General Hospital East, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 021293

Received 6 April 1999/Returned for modification 4 May 1999/Accepted 21 July 1999

Yin Yang 1 (YY1) is a zinc finger-containing transcription factor and a target of viral oncoproteins. To determine the biological role of YY1 in mammalian development, we generated mice deficient for YY1 by gene targeting. Homozygosity for the mutated YY1 allele results in embryonic lethality in the mouse. YY1 mutants undergo implantation and induce uterine decidualization but rapidly degenerate around the time of implantation. A subset of YY1 heterozygote embryos are developmentally retarded and exhibit neurulation defects, suggesting that YY1 may have additional roles during later stages of mouse embryogenesis. Our studies demonstrate an essential function for YY1 in the development of the mouse embryo.

* Corresponding author. Mailing address: Department of Pathology, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115. Phone: (617) 432-4318. Fax: (617) 432-1313. E-mail: yang_shi{at}hms.harvard.edu.

Molecular and Cellular Biology, October 1999, p. 7237-7244, Vol. 19, No. 10
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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