This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ye, H.
Right arrow Articles by Costa, R. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ye, H.
Right arrow Articles by Costa, R. H.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, December 1999, p. 8570-8580, Vol. 19, No. 12
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Premature Expression of the Winged Helix Transcription Factor HFH-11B in Regenerating Mouse Liver Accelerates Hepatocyte Entry into S Phase

Honggang Ye,1,dagger Ai Xuan Holterman,1,2 Kyung W. Yoo,1 Roberta R. Franks,1 and Robert H. Costa1,*

Department of Molecular Genetics1 and Department of Surgery/Division of Pediatric Surgery,2 University of Illinois at Chicago College of Medicine, Chicago, Illinois 60607-7170

Received 23 June 1999/Returned for modification 30 July 1999/Accepted 14 September 1999

Two-thirds partial hepatectomy (PH) induces differentiated cells in the liver remnant to proliferate and regenerate to its original size. The proliferation-specific HNF-3/fork head homolog-11B protein (HFH-11B; also known as Trident and Win) is a family member of the winged helix/fork head transcription factors and in regenerating liver its expression is reactivated prior to hepatocyte entry into DNA replication (S phase). To examine whether HFH-11B regulates hepatocyte proliferation during liver regeneration, we used the -3-kb transthyretin (TTR) promoter to create transgenic mice that displayed ectopic hepatocyte expression of HFH-11B. Liver regeneration studies with the TTR-HFH-11B mice demonstrate that its premature expression resulted in an 8-h acceleration in the onset of hepatocyte DNA replication and mitosis. This liver regeneration phenotype is associated with protracted expression of cyclin D1 and C/EBPbeta , which are involved in stimulating DNA replication and premature expression of M phase promoting cyclin B1 and cdc2. Consistent with the early hepatocyte entry into S phase, regenerating transgenic livers exhibited earlier expression of DNA repair genes (XRCC1, mHR21spA, and mHR23B). Furthermore, in nonregenerating transgenic livers, ectopic HFH-11B expression did not elicit abnormal hepatocyte proliferation, a finding consistent with the retention of the HFH-11B transgene protein in the cytoplasm. We found that nuclear translocation of the HFH-11B transgene protein requires mitogenic signalling induced by PH and that its premature availability in regenerating transgenic liver allowed nuclear translocation to occur 8 h earlier than in wild type.

* Corresponding author. Mailing address: Department of Molecular Genetics (M/C 669), University of Illinois at Chicago, College of Medicine, 900 S. Ashland Ave, Rm. 2220 MBRB, Chicago, IL 60607-7170. Phone: (312) 996-0474. Fax: (312) 355-4010. E-mail: RobCosta{at}uic.edu.

dagger Present address: Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637.

Molecular and Cellular Biology, December 1999, p. 8570-8580, Vol. 19, No. 12
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Chua, P.-J., Yip, G. W.-C., Bay, B.-H. (2009). Cell Cycle Arrest Induced by Hydrogen Peroxide Is Associated with Modulation of Oxidative Stress Related Genes in Breast Cancer Cells. Exp. Biol. Med. 234: 1086-1094 [Abstract] [Full Text]  
  • Li, Q., Zhang, N., Jia, Z., Le, X., Dai, B., Wei, D., Huang, S., Tan, D., Xie, K. (2009). Critical Role and Regulation of Transcription Factor FoxM1 in Human Gastric Cancer Angiogenesis and Progression. Cancer Res. 69: 3501-3509 [Abstract] [Full Text]  
  • Ackermann Misfeldt, A., Costa, R. H., Gannon, M. (2008). {beta}-Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1. Diabetes 57: 3069-3077 [Abstract] [Full Text]  
  • Park, H. J., Costa, R. H., Lau, L. F., Tyner, A. L., Raychaudhuri, P. (2008). Anaphase-Promoting Complex/Cyclosome-Cdh1-Mediated Proteolysis of the Forkhead Box M1 Transcription Factor Is Critical for Regulated Entry into S Phase. Mol. Cell. Biol. 28: 5162-5171 [Abstract] [Full Text]  
  • Lichti-Kaiser, K., Staudinger, J. L. (2008). The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes. Drug Metab. Dispos. 36: 1538-1545 [Abstract] [Full Text]  
  • Wang, M., Chen, M., Zheng, G., Dillard, B., Tallarico, M., Ortiz, Z., Holterman, A.-X. (2008). Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G357-G366 [Abstract] [Full Text]  
  • Wang, I-C., Chen, Y.-J., Hughes, D. E., Ackerson, T., Major, M. L., Kalinichenko, V. V., Costa, R. H., Raychaudhuri, P., Tyner, A. L., Lau, L. F. (2008). FoxM1 Regulates Transcription of JNK1 to Promote the G1/S Transition and Tumor Cell Invasiveness. J. Biol. Chem. 283: 20770-20778 [Abstract] [Full Text]  
  • Li, S. K. M., Smith, D. K., Leung, W. Y., Cheung, A. M. S., Lam, E. W. F., Dimri, G. P., Yao, K.-M. (2008). FoxM1c Counteracts Oxidative Stress-induced Senescence and Stimulates Bmi-1 Expression. J. Biol. Chem. 283: 16545-16553 [Abstract] [Full Text]  
  • Petrovic, V., Costa, R. H., Lau, L. F., Raychaudhuri, P., Tyner, A. L. (2008). FoxM1 Regulates Growth Factor-induced Expression of Kinase-interacting Stathmin (KIS) to Promote Cell Cycle Progression. J. Biol. Chem. 283: 453-460 [Abstract] [Full Text]  
  • Papanicolaou, K. N., Izumiya, Y., Walsh, K. (2008). Forkhead Transcription Factors and Cardiovascular Biology. Circ. Res. 102: 16-31 [Abstract] [Full Text]  
  • Wang, Z., Banerjee, S., Kong, D., Li, Y., Sarkar, F. H. (2007). Down-regulation of Forkhead Box M1 Transcription Factor Leads to the Inhibition of Invasion and Angiogenesis of Pancreatic Cancer Cells. Cancer Res. 67: 8293-8300 [Abstract] [Full Text]  
  • Tan, Y., Raychaudhuri, P., Costa, R. H. (2007). Chk2 Mediates Stabilization of the FoxM1 Transcription Factor To Stimulate Expression of DNA Repair Genes. Mol. Cell. Biol. 27: 1007-1016 [Abstract] [Full Text]  
  • Radhakrishnan, S. K., Bhat, U. G., Hughes, D. E., Wang, I-C., Costa, R. H., Gartel, A. L. (2006). Identification of a Chemical Inhibitor of the Oncogenic Transcription Factor Forkhead Box M1. Cancer Res. 66: 9731-9735 [Abstract] [Full Text]  
  • Zhang, H., Ackermann, A. M., Gusarova, G. A., Lowe, D., Feng, X., Kopsombut, U. G., Costa, R. H., Gannon, M. (2006). The FoxM1 Transcription Factor Is Required to Maintain Pancreatic {beta}-Cell Mass. Mol. Endocrinol. 20: 1853-1866 [Abstract] [Full Text]  
  • Liu, M., Dai, B., Kang, S.-H., Ban, K., Huang, F.-J., Lang, F. F., Aldape, K. D., Xie, T.-x., Pelloski, C. E., Xie, K., Sawaya, R., Huang, S. (2006). FoxM1B Is Overexpressed in Human Glioblastomas and Critically Regulates the Tumorigenicity of Glioma Cells.. Cancer Res. 66: 3593-3602 [Abstract] [Full Text]  
  • Adolphe, C., Hetherington, R., Ellis, T., Wainwright, B. (2006). Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression. Cancer Res. 66: 2081-2088 [Abstract] [Full Text]  
  • Kim, I.-M., Ackerson, T., Ramakrishna, S., Tretiakova, M., Wang, I-C., Kalin, T. V., Major, M. L., Gusarova, G. A., Yoder, H. M., Costa, R. H., Kalinichenko, V. V. (2006). The Forkhead Box m1 Transcription Factor Stimulates the Proliferation of Tumor Cells during Development of Lung Cancer. Cancer Res. 66: 2153-2161 [Abstract] [Full Text]  
  • Kalin, T. V., Wang, I-C., Ackerson, T. J., Major, M. L., Detrisac, C. J., Kalinichenko, V. V., Lyubimov, A., Costa, R. H. (2006). Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Progression of Prostate Carcinomas in both TRAMP and LADY Transgenic Mice. Cancer Res. 66: 1712-1720 [Abstract] [Full Text]  
  • Wang, I-C., Chen, Y.-J., Hughes, D., Petrovic, V., Major, M. L., Park, H. J., Tan, Y., Ackerson, T., Costa, R. H. (2005). Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase. Mol. Cell. Biol. 25: 10875-10894 [Abstract] [Full Text]  
  • Wonsey, D. R., Follettie, M. T. (2005). Loss of the Forkhead Transcription Factor FoxM1 Causes Centrosome Amplification and Mitotic Catastrophe. Cancer Res. 65: 5181-5189 [Abstract] [Full Text]  
  • Ma, R. Y. M., Tong, T. H. K., Cheung, A. M. S., Tsang, A. C. C., Leung, W. Y., Yao, K.-M. (2005). Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1c. J. Cell Sci. 118: 795-806 [Abstract] [Full Text]  
  • Rangwala, S. M., Rich, A. S., Rhoades, B., Shapiro, J. S., Obici, S., Rossetti, L., Lazar, M. A. (2004). Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia. Diabetes 53: 1937-1941 [Abstract] [Full Text]  
  • Major, M. L., Lepe, R., Costa, R. H. (2004). Forkhead Box M1B Transcriptional Activity Requires Binding of Cdk-Cyclin Complexes for Phosphorylation-Dependent Recruitment of p300/CBP Coactivators. Mol. Cell. Biol. 24: 2649-2661 [Abstract] [Full Text]  
  • Kalinichenko, V. V., Major, M. L., Wang, X., Petrovic, V., Kuechle, J., Yoder, H. M., Dennewitz, M. B., Shin, B., Datta, A., Raychaudhuri, P., Costa, R. H. (2004). Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev. 18: 830-850 [Abstract] [Full Text]  
  • Kalinichenko, V. V., Gusarova, G. A., Kim, I.-M., Shin, B., Yoder, H. M., Clark, J., Sapozhnikov, A. M., Whitsett, J. A., Costa, R. H. (2004). Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am. J. Physiol. Lung Cell. Mol. Physiol. 286: L521-L530 [Abstract] [Full Text]  
  • Kalinichenko, V. V., Gusarova, G. A., Tan, Y., Wang, I-C., Major, M. L., Wang, X., Yoder, H. M., Costal, R. H. (2003). Ubiquitous Expression of the Forkhead Box M1B Transgene Accelerates Proliferation of Distinct Pulmonary Cell Types following Lung Injury. J. Biol. Chem. 278: 37888-37894 [Abstract] [Full Text]  
  • Arai, M., Yokosuka, O., Chiba, T., Imazeki, F., Kato, M., Hashida, J., Ueda, Y., Sugano, S., Hashimoto, K., Saisho, H., Takiguchi, M., Seki, N. (2003). Gene Expression Profiling Reveals the Mechanism and Pathophysiology of Mouse Liver Regeneration. J. Biol. Chem. 278: 29813-29818 [Abstract] [Full Text]  
  • Wang, X., Kiyokawa, H., Dennewitz, M. B., Costa, R. H. (2002). The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc. Natl. Acad. Sci. USA 99: 16881-16886 [Abstract] [Full Text]  
  • Lerch-Gaggl, A., Haque, J., Li, J., Ning, G., Traktman, P., Duncan, S. A. (2002). Pescadillo Is Essential for Nucleolar Assembly, Ribosome Biogenesis, and Mammalian Cell Proliferation. J. Biol. Chem. 277: 45347-45355 [Abstract] [Full Text]  
  • Wang, X., Krupczak-Hollis, K., Tan, Y., Dennewitz, M. B., Adami, G. R., Costa, R. H. (2002). Increased Hepatic Forkhead Box M1B (FoxM1B) Levels in Old-aged Mice Stimulated Liver Regeneration through Diminished p27Kip1 Protein Levels and Increased Cdc25B Expression. J. Biol. Chem. 277: 44310-44316 [Abstract] [Full Text]  
  • Teh, M.-T., Wong, S.-T., Neill, G. W., Ghali, L. R., Philpott, M. P., Quinn, A. G. (2002). FOXM1 Is a Downstream Target of Gli1 in Basal Cell Carcinomas. Cancer Res. 62: 4773-4780 [Abstract] [Full Text]  
  • Allen-Jennings, A. E., Hartman, M. G., Kociba, G. J., Hai, T. (2002). The Roles of ATF3 in Liver Dysfunction and the Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression. J. Biol. Chem. 277: 20020-20025 [Abstract] [Full Text]  
  • Kalinichenko, V. V., Zhou, Y., Bhattacharyya, D., Kim, W., Shin, B., Bambal, K., Costa, R. H. (2002). Haploinsufficiency of the Mouse Forkhead Box f1 Gene Causes Defects in Gall Bladder Development. J. Biol. Chem. 277: 12369-12374 [Abstract] [Full Text]  
  • Nag, A., Datta, A., Yoo, K., Bhattacharyya, D., Chakrabortty, A., Wang, X., Slagle, B. L., Costa, R. H., Raychaudhuri, P. (2001). DDB2 Induces Nuclear Accumulation of the Hepatitis B Virus X Protein Independently of Binding to DDB1. J. Virol. 75: 10383-10392 [Abstract] [Full Text]  
  • Wang, X., Quail, E., Hung, N.-J., Tan, Y., Ye, H., Costa, R. H. (2001). Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver. Proc. Natl. Acad. Sci. USA 98: 11468-11473 [Abstract] [Full Text]  
  • Shih, H. H., Xiu, M., Berasi, S. P., Sampson, E. M., Leiter, A., Paulson, K. E., Yee, A. S. (2001). HMG Box Transcriptional Repressor HBP1 Maintains a Proliferation Barrier in Differentiated Liver Tissue. Mol. Cell. Biol. 21: 5723-5732 [Abstract] [Full Text]  
  • Costa, R. H., Kalinichenko, V. V., Lim, L. (2001). Transcription factors in mouse lung development and function. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L823-L838 [Abstract] [Full Text]  
  • Kalinichenko, V. V., Lim, L., Shin, B., Costa, R. H. (2001). Differential expression of forkhead box transcription factors following butylated hydroxytoluene lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L695-L704 [Abstract] [Full Text]  
  • Rausa, F. M., Tan, Y., Zhou, H., Yoo, K. W., Stolz, D. B., Watkins, S. C., Franks, R. R., Unterman, T. G., Costa, R. H. (2000). Elevated Levels of Hepatocyte Nuclear Factor 3beta in Mouse Hepatocytes Influence Expression of Genes Involved in Bile Acid and Glucose Homeostasis. Mol. Cell. Biol. 20: 8264-8282 [Abstract] [Full Text]  
  • Allen-Jennings, A. E., Hartman, M. G., Kociba, G. J., Hai, T. (2001). The Roles of ATF3 in Glucose Homeostasis. A TRANSGENIC MOUSE MODEL WITH LIVER DYSFUNCTION AND DEFECTS IN ENDOCRINE PANCREAS. J. Biol. Chem. 276: 29507-29514 [Abstract] [Full Text]  
  • Chang, B.-D., Swift, M. E., Shen, M., Fang, J., Broude, E. V., Roninson, I. B. (2002). Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc. Natl. Acad. Sci. USA 99: 389-394 [Abstract] [Full Text]  
  • Kalinichenko, V. V., Zhou, Y., Shin, B., Stolz, D. B., Watkins, S. C., Whitsett, J. A., Costa, R. H. (2002). Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L1253-L1265 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»