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Molecular and Cellular Biology, February 1999, p. 1202-1209, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

Lin Liu, Daniel M. Scolnick, Raymond C. Trievel, Hong Bing Zhang, Ronen Marmorstein, Thanos D. Halazonetis,* and Shelley L. Berger*

The Wistar Institute, Philadelphia, Pennsylvania 19104

Received 18 August 1998/Returned for modification 2 October 1998/Accepted 4 November 1998

The p53 tumor suppressor protein is a sequence-specific transcription factor that modulates the response of cells to DNA damage. Recent studies suggest that full transcriptional activity of p53 requires the coactivators CREB binding protein (CBP)/p300 and PCAF. These coactivators interact with each other, and both possess intrinsic histone acetyltransferase activity. Furthermore, p300 acetylates p53 to activate its sequence-specific DNA binding activity in vitro. In this study, we demonstrate that PCAF also acetylates p53 in vitro at a lysine residue distinct from that acetylated by p300 and thereby increases p53's ability to bind to its cognate DNA site. We have generated antibodies to acetylated p53 peptides at either of the two lysine residues that are targeted by PCAF or p300 and have demonstrated that these antibodies are highly specific for both acetylation and the particular site. Using these antibodies, we detect acetylation of these sites in vivo, and interestingly, acetylation at both sites increases in response to DNA-damaging agents. These data indicate that site-specific acetylation of p53 increases under physiological conditions that activate p53 and identify CBP/p300 and PCAF as the probable enzymes that modify p53 in vivo.

* Corresponding author. Mailing address for Shelley L. Berger: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104. Phone: (215) 898-3922. Fax: (215) 898-0663. E-mail: berger{at}wista.wistar.upenn.edu. Mailing address for Thomas D. Halazonetis: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104. Phone: (215) 898-3978. Fax: (215) 898-3868. E-mail: halazonetis{at}wista.wistar.upenn.edu.

Molecular and Cellular Biology, February 1999, p. 1202-1209, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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  • Harrod, R., Nacsa, J., Van Lint, C., Hansen, J., Karpova, T., McNally, J., Franchini, G. (2003). Human Immunodeficiency Virus Type-1 Tat/Co-activator Acetyltransferase Interactions Inhibit p53Lys-320 Acetylation and p53-responsive Transcription. J. Biol. Chem. 278: 12310-12318 [Abstract] [Full Text]  
  • Braastad, C. D., Han, Z., Hendrickson, E. A. (2003). Constitutive DNase I Hypersensitivity of p53-Regulated Promoters. J. Biol. Chem. 278: 8261-8268 [Abstract] [Full Text]  
  • Zeng, S. X., Jin, Y., Kuninger, D. T., Rotwein, P., Lu, H. (2003). The Acetylase Activity of p300 Is Dispensable for MDM2 Stabilization. J. Biol. Chem. 278: 7453-7458 [Abstract] [Full Text]  
  • Li, M., Luo, J., Brooks, C. L., Gu, W. (2002). Acetylation of p53 Inhibits Its Ubiquitination by Mdm2. J. Biol. Chem. 277: 50607-50611 [Abstract] [Full Text]  
  • Xie, A.-Y., Bermudez, V. P., Folk, W. R. (2002). Stimulation of DNA Replication from the Polyomavirus Origin by PCAF and GCN5 Acetyltransferases: Acetylation of Large T Antigen. Mol. Cell. Biol. 22: 7907-7918 [Abstract] [Full Text]  
  • Mauser, A., Saito, S.'i., Appella, E., Anderson, C. W., Seaman, W. T., Kenney, S. (2002). The Epstein-Barr Virus Immediate-Early Protein BZLF1 Regulates p53 Function through Multiple Mechanisms. J. Virol. 76: 12503-12512 [Abstract] [Full Text]  
  • Kawauchi, J., Zhang, C., Nobori, K., Hashimoto, Y., Adachi, M. T., Noda, A., Sunamori, M., Kitajima, S. (2002). Transcriptional Repressor Activating Transcription Factor 3 Protects Human Umbilical Vein Endothelial Cells from Tumor Necrosis Factor-alpha -induced Apoptosis through Down-regulation of p53 Transcription. J. Biol. Chem. 277: 39025-39034 [Abstract] [Full Text]  
  • Jin, Y., Zeng, S. X., Dai, M.-S., Yang, X.-J., Lu, H. (2002). MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation. J. Biol. Chem. 277: 30838-30843 [Abstract] [Full Text]  
  • Ard, P. G., Chatterjee, C., Kunjibettu, S., Adside, L. R., Gralinski, L. E., McMahon, S. B. (2002). Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes. Mol. Cell. Biol. 22: 5650-5661 [Abstract] [Full Text]  
  • Harada, J. N., Shevchenko, A., Shevchenko, A., Pallas, D. C., Berk, A. J. (2002). Analysis of the Adenovirus E1B-55K-Anchored Proteome Reveals Its Link to Ubiquitination Machinery. J. Virol. 76: 9194-9206 [Abstract] [Full Text]  
  • Suhara, W., Yoneyama, M., Kitabayashi, I., Fujita, T. (2002). Direct Involvement of CREB-binding Protein/p300 in Sequence-specific DNA Binding of Virus-activated Interferon Regulatory Factor-3 Holocomplex. J. Biol. Chem. 277: 22304-22313 [Abstract] [Full Text]  
  • Hong, W., Kim, A. Y., Ky, S., Rakowski, C., Seo, S.-B., Chakravarti, D., Atchison, M., Blobel, G. A. (2002). Inhibition of CBP-Mediated Protein Acetylation by the Ets Family Oncoprotein PU.1. Mol. Cell. Biol. 22: 3729-3743 [Abstract] [Full Text]  
  • Fu, M., Wang, C., Wang, J., Zhang, X., Sakamaki, T., Yeung, Y. G., Chang, C., Hopp, T., Fuqua, S. A. W., Jaffray, E., Hay, R. T., Palvimo, J. J., Janne, O. A., Pestell, R. G. (2002). Androgen Receptor Acetylation Governs trans Activation and MEKK1-Induced Apoptosis without Affecting In Vitro Sumoylation and trans-Repression Function. Mol. Cell. Biol. 22: 3373-3388 [Abstract] [Full Text]  
  • Huang, Y., Tan, M., Gosink, M., Wang, K. K. W., Sun, Y. (2002). Histone Deacetylase 5 Is Not a p53 Target Gene, But Its Overexpression Inhibits Tumor Cell Growth and Induces Apoptosis. Cancer Res. 62: 2913-2922 [Abstract] [Full Text]  
  • Subramanian, C., Hasan, S., Rowe, M., Hottiger, M., Orre, R., Robertson, E. S. (2002). Epstein-Barr Virus Nuclear Antigen 3C and Prothymosin Alpha Interact with the p300 Transcriptional Coactivator at the CH1 and CH3/HAT Domains and Cooperate in Regulation of Transcription and Histone Acetylation. J. Virol. 76: 4699-4708 [Abstract] [Full Text]  
  • Braastad, C. D., Leguia, M., Hendrickson, E. A. (2002). Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. Nucleic Acids Res 30: 1713-1724 [Abstract] [Full Text]  
  • Alarcon-Vargas, D., Ronai, Z.'e. (2002). p53-Mdm2--the affair that never ends. Carcinogenesis 23: 541-547 [Abstract] [Full Text]  
  • Song, C.-Z., Keller, K., Murata, K., Asano, H., Stamatoyannopoulos, G. (2002). Functional Interaction between Coactivators CBP/p300, PCAF, and Transcription Factor FKLF2. J. Biol. Chem. 277: 7029-7036 [Abstract] [Full Text]  


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