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Molecular and Cellular Biology, February 1999, p. 1301-1312, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth

Mark K. Abe,1 Wen-Liang Kuo,2 Marc B. Hershenson,1 and Marsha Rich Rosner2,*

Department of Pediatrics1 and Ben May Institute for Cancer Research and Department of Pharmacological and Physiological Sciences,2 University of Chicago, Chicago, Illinois 60637

Received 22 July 1998/Returned for modification 31 August 1998/Accepted 27 October 1998

Mitogen-activated protein (MAP) kinases play distinct roles in a variety of cellular signaling pathways and are regulated through multiple mechanisms. In this study, a novel 61-kDa member of the MAP kinase family, termed extracellular signal-regulated kinase 7 (ERK7), has been cloned and characterized. Although it has the signature TEY activation motif of ERK1 and ERK2, ERK7 is not activated by extracellular stimuli that typically activate ERK1 and ERK2 or by common activators of c-Jun N-terminal kinase (JNK) and p38 kinase. Instead, ERK7 has appreciable constitutive activity in serum-starved cells that is dependent on the presence of its C-terminal domain. Interestingly, the C-terminal tail, not the kinase domain, of ERK7 regulates its nuclear localization and inhibition of growth. Taken together, these results elucidate a novel type of MAP kinase whereby interactions via its C-terminal tail, rather than extracellular signal-mediated activation cascades, regulate its activity, localization, and function.

* Corresponding author. Mailing address: Ben May Institute for Cancer Research, University of Chicago, 5841 S. Maryland Ave., MC 6027, Chicago, IL 60637-1470. Phone: (773) 702-0380. Fax: (773) 702-4634. E-mail: mrosner{at}ben-may.bsd.uchicago.edu.

Molecular and Cellular Biology, February 1999, p. 1301-1312, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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