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Molecular and Cellular Biology, February 1999, p. 1460-1469, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF Complex, and Alters the Ability of BRG1 To Induce Growth Arrest

Frances Shanahan, Wolfgang Seghezzi, David Parry, Daniel Mahony, and Emma Lees*

Cell Signaling Department, DNAX Research Institute, Palo Alto, California 94304

Received 9 September 1998/Returned for modification 16 October 1998/Accepted 7 November 1998

SWI-SNF complexes have been implicated in transcriptional regulation by chromatin remodeling. We have identified an interaction between two components of the mammalian SWI-SNF complex and cyclin E, an essential cell cycle regulatory protein required for G1/S transition. BRG1 and BAF155, mammalian homologs of yeast SWI2 and SWI3, respectively, are found in cyclin E complexes and are phosphorylated by cyclin E-associated kinase activity. In this report, we show that overexpression of BRG1 causes growth arrest and induction of senescence-associated beta -galactosidase activity, which can be overcome by cyclin E. Our results suggest that cyclin E may modulate the activity of the SWI-SNF apparatus to maintain the chromatin in a transcriptionally permissive state.

* Corresponding author. Mailing address: Cell Signaling Department, DNAX Research Institute, 901 California Ave., Palo Alto, CA 94304. Phone: (650) 496-1257. Fax: (650) 496-1200. E-mail: lees{at}dnax.org.

Molecular and Cellular Biology, February 1999, p. 1460-1469, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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