This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Howell, B. W.
Right arrow Articles by Cooper, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Howell, B. W.
Right arrow Articles by Cooper, J. A.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, July 1999, p. 5179-5188, Vol. 19, No. 7
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and to Phospholipids

Brian W. Howell,1 Lorene M. Lanier,2 Ronald Frank,3 Frank B. Gertler,2 and Jonathan A. Cooper1,*

Fred Hutchinson Cancer Research Center, Seattle, Washington 981091; Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-43072; and AG Molecular Recognition, GBF, D-38124 Braunschweig, Germany3

Received 22 December 1998/Returned for modification 8 February 1999/Accepted 12 April 1999

Disabled gene products are important for nervous system development in drosophila and mammals. In mice, the Dab1 protein is thought to function downstream of the extracellular protein Reln during neuronal positioning. The structures of Dab proteins suggest that they mediate protein-protein or protein-membrane docking functions. Here we show that the amino-terminal phosphotyrosine-binding (PTB) domain of Dab1 binds to the transmembrane glycoproteins of the amyloid precursor protein (APP) and low-density lipoprotein receptor families and the cytoplasmic signaling protein Ship. Dab1 associates with the APP cytoplasmic domain in transfected cells and is coexpressed with APP in hippocampal neurons. Screening of a set of altered peptide sequences showed that the sequence GYXNPXY present in APP family members is an optimal binding sequence, with approximately 0.5 µM affinity. Unlike other PTB domains, the Dab1 PTB does not bind to tyrosine-phosphorylated peptide ligands. The PTB domain also binds specifically to phospholipid bilayers containing phosphatidylinositol 4P (PtdIns4P) or PtdIns4,5P2 in a manner that does not interfere with protein binding. We propose that the PTB domain permits Dab1 to bind specifically to transmembrane proteins containing an NPXY internalization signal.

* Corresponding author. Mailing address: FHCRC, Mailstop A2-025, 1100 Fairview Ave. N, Seattle WA 98109. Phone: (206) 667-4454. Fax: (206) 667-6522. E-mail: jcooper{at}fhcrc.org.

Molecular and Cellular Biology, July 1999, p. 5179-5188, Vol. 19, No. 7
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Fuentealba, R. A., Liu, Q., Kanekiyo, T., Zhang, J., Bu, G. (2009). Low Density Lipoprotein Receptor-related Protein 1 Promotes Anti-apoptotic Signaling in Neurons by Activating Akt Survival Pathway. J. Biol. Chem. 284: 34045-34053 [Abstract] [Full Text]  
  • Austin, S. A., Sens, M. A., Combs, C. K. (2009). Amyloid Precursor Protein Mediates a Tyrosine Kinase-Dependent Activation Response in Endothelial Cells. J. Neurosci. 29: 14451-14462 [Abstract] [Full Text]  
  • Laky, K., Annaert, W., Fowlkes, B. J. (2009). Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development. Int Immunol 21: 1163-1174 [Abstract] [Full Text]  
  • Keyel, P. A., Thieman, J. R., Roth, R., Erkan, E., Everett, E. T., Watkins, S. C., Heuser, J. E., Traub, L. M. (2008). The AP-2 Adaptor {beta}2 Appendage Scaffolds Alternate Cargo Endocytosis. Mol. Biol. Cell 19: 5309-5326 [Abstract] [Full Text]  
  • Li, H., Koshiba, S., Hayashi, F., Tochio, N., Tomizawa, T., Kasai, T., Yabuki, T., Motoda, Y., Harada, T., Watanabe, S., Inoue, M., Hayashizaki, Y., Tanaka, A., Kigawa, T., Yokoyama, S. (2008). Structure of the C-terminal Phosphotyrosine Interaction Domain of Fe65L1 Complexed with the Cytoplasmic Tail of Amyloid Precursor Protein Reveals a Novel Peptide Binding Mode. J. Biol. Chem. 283: 27165-27178 [Abstract] [Full Text]  
  • Radzimanowski, J., Ravaud, S., Schlesinger, S., Koch, J., Beyreuther, K., Sinning, I., Wild, K. (2008). Crystal Structure of the Human Fe65-PTB1 Domain. J. Biol. Chem. 283: 23113-23120 [Abstract] [Full Text]  
  • Mishra, S. K., Jha, A., Steinhauser, A. L., Kokoza, V. A., Washabaugh, C. H., Raikhel, A. S., Foster, W. A., Traub, L. M. (2008). Internalization of LDL-receptor superfamily yolk-protein receptors during mosquito oogenesis involves transcriptional regulation of PTB-domain adaptors. J. Cell Sci. 121: 1264-1274 [Abstract] [Full Text]  
  • Hoe, H.-S., Minami, S. S., Makarova, A., Lee, J., Hyman, B. T., Matsuoka, Y., Rebeck, G. W. (2008). Fyn Modulation of Dab1 Effects on Amyloid Precursor Protein and ApoE Receptor 2 Processing. J. Biol. Chem. 283: 6288-6299 [Abstract] [Full Text]  
  • Shrivastava-Ranjan, P., Faundez, V., Fang, G., Rees, H., Lah, J. J., Levey, A. I., Kahn, R. A. (2008). Mint3/X11{gamma} Is an ADP-Ribosylation Factor-dependent Adaptor that Regulates the Traffic of the Alzheimer's Precursor Protein from the Trans-Golgi Network. Mol. Biol. Cell 19: 51-64 [Abstract] [Full Text]  
  • Young-Pearse, T. L., Bai, J., Chang, R., Zheng, J. B., LoTurco, J. J., Selkoe, D. J. (2007). A Critical Function for -Amyloid Precursor Protein in Neuronal Migration Revealed by In Utero RNA Interference. J. Neurosci. 27: 14459-14469 [Abstract] [Full Text]  
  • Wiley, J. C., Smith, E. A., Hudson, M. P., Ladiges, W. C., Bothwell, M. (2007). Fe65 Stimulates Proteolytic Liberation of the beta-Amyloid Precursor Protein Intracellular Domain. J. Biol. Chem. 282: 33313-33325 [Abstract] [Full Text]  
  • Kerjan, G., Gleeson, J. G. (2007). A missed exit: Reelin sets in motion Dab1 polyubiquitination to put the break on neuronal migration. Genes Dev. 21: 2850-2854 [Full Text]  
  • Eisele, Y. S., Baumann, M., Klebl, B., Nordhammer, C., Jucker, M., Kilger, E. (2007). Gleevec Increases Levels of the Amyloid Precursor Protein Intracellular Domain and of the Amyloid-beta degrading Enzyme Neprilysin. Mol. Biol. Cell 18: 3591-3600 [Abstract] [Full Text]  
  • Romero, D. G., Yanes, L. L., de Rodriguez, A. F., Plonczynski, M. W., Welsh, B. L., Reckelhoff, J. F., Gomez-Sanchez, E. P., Gomez-Sanchez, C. E. (2007). Disabled-2 Is Expressed in Adrenal Zona Glomerulosa and Is Involved in Aldosterone Secretion. Endocrinology 148: 2644-2652 [Abstract] [Full Text]  
  • Nizzari, M., Venezia, V., Repetto, E., Caorsi, V., Magrassi, R., Gagliani, M. C., Carlo, P., Florio, T., Schettini, G., Tacchetti, C., Russo, T., Diaspro, A., Russo, C. (2007). Amyloid Precursor Protein and Presenilin1 Interact with the Adaptor GRB2 and Modulate ERK 1,2 Signaling. J. Biol. Chem. 282: 13833-13844 [Abstract] [Full Text]  
  • Yamashita, N., Uchida, Y., Ohshima, T., Hirai, S.-i., Nakamura, F., Taniguchi, M., Mikoshiba, K., Honnorat, J., Kolattukudy, P., Thomasset, N., Takei, K., Takahashi, T., Goshima, Y. (2006). Collapsin Response Mediator Protein 1 Mediates Reelin Signaling in Cortical Neuronal Migration. J. Neurosci. 26: 13357-13362 [Abstract] [Full Text]  
  • Honda, T., Nakajima, K. (2006). Mouse Disabled1 (DAB1) Is a Nucleocytoplasmic Shuttling Protein. J. Biol. Chem. 281: 38951-38965 [Abstract] [Full Text]  
  • Qiu, S., Zhao, L. F., Korwek, K. M., Weeber, E. J. (2006). Differential Reelin-Induced Enhancement of NMDA and AMPA Receptor Activity in the Adult Hippocampus. J. Neurosci. 26: 12943-12955 [Abstract] [Full Text]  
  • Hoe, H.-S., Tran, T. S., Matsuoka, Y., Howell, B. W., Rebeck, G. W. (2006). DAB1 and Reelin Effects on Amyloid Precursor Protein and ApoE Receptor 2 Trafficking and Processing. J. Biol. Chem. 281: 35176-35185 [Abstract] [Full Text]  
  • Smith, M. J., Hardy, W. R., Murphy, J. M., Jones, N., Pawson, T. (2006). Screening for PTB Domain Binding Partners and Ligand Specificity Using Proteome-Derived NPXY Peptide Arrays. Mol. Cell. Biol. 26: 8461-8474 [Abstract] [Full Text]  
  • DeKroon, R., Robinette, J. B., Hjelmeland, A. B., Wiggins, E., Blackwell, M., Mihovilovic, M., Fujii, M., York, J., Hart, J., Kontos, C., Rich, J., Strittmatter, W. J. (2006). APOE4-VLDL Inhibits the HDL-Activated Phosphatidylinositol 3-Kinase/Akt Pathway via the Phosphoinositol Phosphatase SHIP2. Circ. Res. 99: 829-836 [Abstract] [Full Text]  
  • Yang, D.-H., Fazili, Z., Smith, E. R., Cai, K. Q., Klein-Szanto, A., Cohen, C., Horowitz, I. R., Xu, X.-X. (2006). Disabled-2 Heterozygous Mice Are Predisposed to Endometrial and Ovarian Tumorigenesis and Exhibit Sex-Biased Embryonic Lethality in a p53-Null Background. Am. J. Pathol. 169: 258-267 [Abstract] [Full Text]  
  • Botella-Lopez, A., Burgaya, F., Gavin, R., Garcia-Ayllon, M. S., Gomez-Tortosa, E., Pena-Casanova, J., Urena, J. M., Del Rio, J. A., Blesa, R., Soriano, E., Saez-Valero, J. (2006). Reelin expression and glycosylation patterns are altered in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 103: 5573-5578 [Abstract] [Full Text]  
  • Pramatarova, A., Ochalski, P. G., Lee, C.-H., Howell, B. W. (2006). Mouse Disabled 1 Regulates the Nuclear Position of Neurons in a Drosophila Eye Model. Mol. Cell. Biol. 26: 1510-1517 [Abstract] [Full Text]  
  • Beffert, U., Durudas, A., Weeber, E. J., Stolt, P. C., Giehl, K. M., Sweatt, J. D., Hammer, R. E., Herz, J. (2006). Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity. J. Neurosci. 26: 2041-2052 [Abstract] [Full Text]  
  • Mayer, H., Duit, S., Hauser, C., Schneider, W. J., Nimpf, J. (2006). Reconstitution of the Reelin Signaling Pathway in Fibroblasts Demonstrates that Dab1 Phosphorylation Is Independent of Receptor Localization in Lipid Rafts. Mol. Cell. Biol. 26: 19-27 [Abstract] [Full Text]  
  • Kuo, G., Arnaud, L., Kronstad-O'Brien, P., Cooper, J. A. (2005). Absence of Fyn and Src Causes a Reeler-Like Phenotype. J. Neurosci. 25: 8578-8586 [Abstract] [Full Text]  
  • Nagai, J., Christensen, E. I., Morris, S. M., Willnow, T. E., Cooper, J. A., Nielsen, R. (2005). Mutually dependent localization of megalin and Dab2 in the renal proximal tubule. Am. J. Physiol. Renal Physiol. 289: F569-F576 [Abstract] [Full Text]  
  • Gonzalez-Billault, C., Del Rio, J. A., Urena, J. M., Jimenez-Mateos, E. M., Barallobre, M. J., Pascual, M., Pujadas, L., Simo, S., Torre, A. L., Gavin, R., Wandosell, F., Soriano, E., Avila, J. (2005). A role of MAP1B in Reelin-dependent Neuronal Migration. Cereb Cortex 15: 1134-1145 [Abstract] [Full Text]  
  • Yoon, I.-S., Pietrzik, C. U., Kang, D. E., Koo, E. H. (2005). Sequences from the Low Density Lipoprotein Receptor-related Protein (LRP) Cytoplasmic Domain Enhance Amyloid {beta} Protein Production via the {beta}-Secretase Pathway without Altering Amyloid Precursor Protein/LRP Nuclear Signaling. J. Biol. Chem. 280: 20140-20147 [Abstract] [Full Text]  
  • Morimura, T., Hattori, M., Ogawa, M., Mikoshiba, K. (2005). Disabled1 Regulates the Intracellular Trafficking of Reelin Receptors. J. Biol. Chem. 280: 16901-16908 [Abstract] [Full Text]  
  • Stolt, P. C., Chen, Y., Liu, P., Bock, H. H., Blacklow, S. C., Herz, J. (2005). Phosphoinositide Binding by the Disabled-1 PTB Domain Is Necessary for Membrane Localization and Reelin Signal Transduction. J. Biol. Chem. 280: 9671-9677 [Abstract] [Full Text]  
  • Homayouni, R., Heinrich, K., Wei, L., Berry, M. W. (2005). Gene clustering by Latent Semantic Indexing of MEDLINE abstracts. Bioinformatics 21: 104-115 [Abstract] [Full Text]  
  • Khvotchev, M., Sudhof, T. C. (2004). Proteolytic Processing of Amyloid-{beta} Precursor Protein by Secretases Does Not Require Cell Surface Transport. J. Biol. Chem. 279: 47101-47108 [Abstract] [Full Text]  
  • Du, L., Post, S. R. (2004). Macrophage colony-stimulating factor differentially regulates low density lipoprotein and transferrin receptors. J. Lipid Res. 45: 1733-1740 [Abstract] [Full Text]  
  • Chen, K., Ochalski, P. G., Tran, T. S., Sahir, N., Schubert, M., Pramatarova, A., Howell, B. W. (2004). Interaction between Dab1 and CrkII is promoted by Reelin signaling. J. Cell Sci. 117: 4527-4536 [Abstract] [Full Text]  
  • Bock, H. H., Jossin, Y., May, P., Bergner, O., Herz, J. (2004). Apolipoprotein E Receptors Are Required for Reelin-induced Proteasomal Degradation of the Neuronal Adaptor Protein Disabled-1. J. Biol. Chem. 279: 33471-33479 [Abstract] [Full Text]  
  • Michaely, P., Li, W.-P., Anderson, R. G. W., Cohen, J. C., Hobbs, H. H. (2004). The Modular Adaptor Protein ARH Is Required for Low Density Lipoprotein (LDL) Binding and Internalization but Not for LDL Receptor Clustering in Coated Pits. J. Biol. Chem. 279: 34023-34031 [Abstract] [Full Text]  
  • Louvi, A., Sisodia, S. S., Grove, E. A. (2004). Presenilin 1 in migration and morphogenesis in the central nervous system. Development 131: 3093-3105 [Abstract] [Full Text]  
  • Perkinton, M. S., Standen, C. L., Lau, K.-F., Kesavapany, S., Byers, H. L., Ward, M., McLoughlin, D. M., Miller, C. C. J. (2004). The c-Abl Tyrosine Kinase Phosphorylates the Fe65 Adaptor Protein to Stimulate Fe65/Amyloid Precursor Protein Nuclear Signaling. J. Biol. Chem. 279: 22084-22091 [Abstract] [Full Text]  
  • Bedirian, A., Baldwin, C., Abe, J.-i., Takano, T., Lemay, S. (2004). Pleckstrin Homology and Phosphotyrosine-binding Domain-dependent Membrane Association and Tyrosine Phosphorylation of Dok-4, an Inhibitory Adapter Molecule Expressed in Epithelial Cells. J. Biol. Chem. 279: 19335-19349 [Abstract] [Full Text]  
  • Sondag, C. M., Combs, C. K. (2004). Amyloid Precursor Protein Mediates Proinflammatory Activation of Monocytic Lineage Cells. J. Biol. Chem. 279: 14456-14463 [Abstract] [Full Text]  
  • Qin, H., Percival-Smith, A., Li, C., Jia, C. Y. H., Gloor, G., Li, S. S.-C. (2004). A Novel Transmembrane Protein Recruits Numb to the Plasma Membrane during Asymmetric Cell Division. J. Biol. Chem. 279: 11304-11312 [Abstract] [Full Text]  
  • Beffert, U., Stolt, P. C., Herz, J. (2004). Functions of lipoprotein receptors in neurons. J. Lipid Res. 45: 403-409 [Abstract] [Full Text]  
  • Beffert, U., Weeber, E. J., Morfini, G., Ko, J., Brady, S. T., Tsai, L.-H., Sweatt, J. D., Herz, J. (2004). Reelin and Cyclin-Dependent Kinase 5-Dependent Signals Cooperate in Regulating Neuronal Migration and Synaptic Transmission. J. Neurosci. 24: 1897-1906 [Abstract] [Full Text]  
  • Ho, A., Sudhof, T. C. (2004). Binding of F-spondin to amyloid-{beta} precursor protein: A candidate amyloid-{beta} precursor protein ligand that modulates amyloid-{beta} precursor protein cleavage. Proc. Natl. Acad. Sci. USA 101: 2548-2553 [Abstract] [Full Text]  
  • Strasser, V., Fasching, D., Hauser, C., Mayer, H., Bock, H. H., Hiesberger, T., Herz, J., Weeber, E. J., Sweatt, J. D., Pramatarova, A., Howell, B., Schneider, W. J., Nimpf, J. (2004). Receptor Clustering Is Involved in Reelin Signaling. Mol. Cell. Biol. 24: 1378-1386 [Abstract] [Full Text]  
  • Makarova, A., Mikhailenko, I., Bugge, T. H., List, K., Lawrence, D. A., Strickland, D. K. (2003). The Low Density Lipoprotein Receptor-related Protein Modulates Protease Activity in the Brain by Mediating the Cellular Internalization of Both Neuroserpin and Neuroserpin-Tissue-type Plasminogen Activator Complexes. J. Biol. Chem. 278: 50250-50258 [Abstract] [Full Text]  
  • Lee, J.-H., Lau, K.-F., Perkinton, M. S., Standen, C. L., Shemilt, S. J. A., Mercken, L., Cooper, J. D., McLoughlin, D. M., Miller, C. C. J. (2003). The Neuronal Adaptor Protein X11{alpha} Reduces A{beta} Levels in the Brains of Alzheimer's APPswe Tg2576 Transgenic Mice. J. Biol. Chem. 278: 47025-47029 [Abstract] [Full Text]  
  • Kamikura, D. M., Cooper, J. A. (2003). Lipoprotein receptors and a Disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 17: 2798-2811 [Abstract] [Full Text]  
  • Soutar, A. K., Naoumova, R. P., Traub, L. M. (2003). Genetics, Clinical Phenotype, and Molecular Cell Biology of Autosomal Recessive Hypercholesterolemia. Arterioscler. Thromb. Vasc. Bio. 23: 1963-1970 [Abstract] [Full Text]  
  • Traub, L. M. (2003). Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection. JCB 163: 203-208 [Abstract] [Full Text]  
  • Pramatarova, A., Ochalski, P. G., Chen, K., Gropman, A., Myers, S., Min, K.-T., Howell, B. W. (2003). Nck{beta} Interacts with Tyrosine-Phosphorylated Disabled 1 and Redistributes in Reelin-Stimulated Neurons. Mol. Cell. Biol. 23: 7210-7221 [Abstract] [Full Text]  
  • Bock, H. H., Jossin, Y., Liu, P., Forster, E., May, P., Goffinet, A. M., Herz, J. (2003). Phosphatidylinositol 3-Kinase Interacts with the Adaptor Protein Dab1 in Response to Reelin Signaling and Is Required for Normal Cortical Lamination. J. Biol. Chem. 278: 38772-38779 [Abstract] [Full Text]  
  • Yun, M., Keshvara, L., Park, C.-G., Zhang, Y.-M., Dickerson, J. B., Zheng, J., Rock, C. O., Curran, T., Park, H.-W. (2003). Crystal Structures of the Dab Homology Domains of Mouse Disabled 1 and 2. J. Biol. Chem. 278: 36572-36581 [Abstract] [Full Text]  
  • Schlessinger, J., Lemmon, M. A. (2003). SH2 and PTB Domains in Tyrosine Kinase Signaling. Sci Signal 2003: re12-re12 [Abstract] [Full Text]  
  • Dahlen, D. D., Broudy, V. C., Drachman, J. G. (2003). Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs. Blood 102: 102-108 [Abstract] [Full Text]  
  • Ben-Shlomo, I., Yu Hsu, S., Rauch, R., Kowalski, H. W., Hsueh, A. J. W. (2003). Signaling Receptome: A Genomic and Evolutionary Perspective of Plasma Membrane Receptors Involved in Signal Transduction. Sci Signal 2003: re9-re9 [Abstract] [Full Text]  
  • Jossin, Y., Bar, I., Ignatova, N., Tissir, F., de Rouvroit, C. L., Goffinet, A. M. (2003). The Reelin Signaling Pathway: Some Recent Developments. Cereb Cortex 13: 627-633 [Abstract] [Full Text]  
  • Gianni, D., Zambrano, N., Bimonte, M., Minopoli, G., Mercken, L., Talamo, F., Scaloni, A., Russo, T. (2003). Platelet-derived Growth Factor Induces the beta -gamma -Secretase-mediated Cleavage of Alzheimer's Amyloid Precursor Protein through a Src-Rac-dependent Pathway. J. Biol. Chem. 278: 9290-9297 [Abstract] [Full Text]  
  • Calderwood, D. A., Fujioka, Y., de Pereda, J. M., Garcia-Alvarez, B., Nakamoto, T., Margolis, B., McGlade, C. J., Liddington, R. C., Ginsberg, M. H. (2003). Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling. Proc. Natl. Acad. Sci. USA 100: 2272-2277 [Abstract] [Full Text]  
  • Bar, I., Tissir, F., Lambert de Rouvroit, C., De Backer, O., Goffinet, A. M. (2003). The Gene Encoding Disabled-1 (DAB1), the Intracellular Adaptor of the Reelin Pathway, Reveals Unusual Complexity in Human and Mouse. J. Biol. Chem. 278: 5802-5812 [Abstract] [Full Text]  
  • Brich, J., Shie, F.-S., Howell, B. W., Li, R., Tus, K., Wakeland, E. K., Jin, L.-W., Mumby, M., Churchill, G., Herz, J., Cooper, J. A. (2003). Genetic Modulation of Tau Phosphorylation in the Mouse. J. Neurosci. 23: 187-192 [Abstract] [Full Text]  
  • Beffert, U., Morfini, G., Bock, H. H., Reyna, H., Brady, S. T., Herz, J. (2002). Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3beta. J. Biol. Chem. 277: 49958-49964 [Abstract] [Full Text]  
  • Mishra, S. K., Watkins, S. C., Traub, L. M. (2002). The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery. Proc. Natl. Acad. Sci. USA 99: 16099-16104 [Abstract] [Full Text]  
  • Russo, C., Dolcini, V., Salis, S., Venezia, V., Zambrano, N., Russo, T., Schettini, G. (2002). Signal Transduction through Tyrosine-phosphorylated C-terminal Fragments of Amyloid Precursor Protein via an Enhanced Interaction with Shc/Grb2 Adaptor Proteins in Reactive Astrocytes of Alzheimer's Disease Brain. J. Biol. Chem. 277: 35282-35288 [Abstract] [Full Text]  
  • Bruni, P., Minopoli, G., Brancaccio, T., Napolitano, M., Faraonio, R., Zambrano, N., Hansen, U., Russo, T. (2002). Fe65, a Ligand of the Alzheimer's beta -Amyloid Precursor Protein, Blocks Cell Cycle Progression by Down-regulating Thymidylate Synthase Expression. J. Biol. Chem. 277: 35481-35488 [Abstract] [Full Text]  
  • Keshvara, L., Magdaleno, S., Benhayon, D., Curran, T. (2002). Cyclin-Dependent Kinase 5 Phosphorylates Disabled 1 Independently of Reelin Signaling. J. Neurosci. 22: 4869-4877 [Abstract] [Full Text]  
  • Calderwood, D. A., Yan, B., de Pereda, J. M., Alvarez, B. G., Fujioka, Y., Liddington, R. C., Ginsberg, M. H. (2002). The Phosphotyrosine Binding-like Domain of Talin Activates Integrins. J. Biol. Chem. 277: 21749-21758 [Abstract] [Full Text]  
  • Loukinova, E., Ranganathan, S., Kuznetsov, S., Gorlatova, N., Migliorini, M. M., Loukinov, D., Ulery, P. G., Mikhailenko, I., Lawrence, D. A., Strickland, D. K. (2002). Platelet-derived Growth Factor (PDGF)-induced Tyrosine Phosphorylation of the Low Density Lipoprotein Receptor-related Protein (LRP). EVIDENCE FOR INTEGRATED CO-RECEPTOR FUNCTION BETWEEN LRP AND THE PDGF. J. Biol. Chem. 277: 15499-15506 [Abstract] [Full Text]  
  • Tarr, P. E., Roncarati, R., Pelicci, G., Pelicci, P. G., D'Adamio, L. (2002). Tyrosine Phosphorylation of the beta -Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc. J. Biol. Chem. 277: 16798-16804 [Abstract] [Full Text]  
  • Yan, K. S., Kuti, M., Yan, S., Mujtaba, S., Farooq, A., Goldfarb, M. P., Zhou, M.-M. (2002). FRS2 PTB Domain Conformation Regulates Interactions with Divergent Neurotrophic Receptors. J. Biol. Chem. 277: 17088-17094 [Abstract] [Full Text]  
  • Su, H. P., Nakada-Tsukui, K., Tosello-Trampont, A.-C., Li, Y., Bu, G., Henson, P. M., Ravichandran, K. S. (2002). Interaction of CED-6/GULP, an Adapter Protein Involved in Engulfment of Apoptotic Cells with CED-1 and CD91/Low Density Lipoprotein Receptor-related Protein (LRP). J. Biol. Chem. 277: 11772-11779 [Abstract] [Full Text]  
  • Hu, Q., Cool, B. H., Wang, B., Hearn, M. G., Martin, G. M. (2002). A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type. Hum Mol Genet 11: 465-475 [Abstract] [Full Text]  
  • Zambrano, N., Bimonte, M., Arbucci, S., Gianni, D., Russo, T., Bazzicalupo, P. (2002). feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and {beta}-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping. J. Cell Sci. 115: 1411-1422 [Abstract] [Full Text]  
  • Herrick, T. M., Cooper, J. A. (2002). A hypomorphic allele of dab1 reveals regional differences in reelin-Dab1 signaling during brain development. Development 129: 787-796 [Abstract] [Full Text]  
  • Smith, E. R., Capo-chichi, C. D., He, J., Smedberg, J. L., Yang, D.-H., Prowse, A. H., Godwin, A. K., Hamilton, T. C., Xu, X.-X. (2001). Disabled-2 Mediates c-Fos Suppression and the Cell Growth Regulatory Activity of Retinoic Acid in Embryonic Carcinoma Cells. J. Biol. Chem. 276: 47303-47310 [Abstract] [Full Text]  
  • Christensen, E. I., Birn, H. (2001). Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule. Am. J. Physiol. Renal Physiol. 280: F562-F573 [Abstract] [Full Text]  
  • Li, Y., van Kerkhof, P., Marzolo, M. P., Strous, G. J., Bu, G. (2001). Identification of a Major Cyclic AMP-Dependent Protein Kinase A Phosphorylation Site within the Cytoplasmic Tail of the Low-Density Lipoprotein Receptor-Related Protein: Implication for Receptor-Mediated Endocytosis. Mol. Cell. Biol. 21: 1185-1195 [Abstract] [Full Text]  
  • Hyman, B. T., Strickland, D., Rebeck, G. W. (2000). Role of the Low-density Lipoprotein Receptor-Related Protein in {beta}-Amyloid Metabolism and Alzheimer Disease. Arch Neurol 57: 646-650 [Abstract] [Full Text]  
  • Su, H. P., Brugnera, E., Van Criekinge, W., Smits, E., Hengartner, M., Bogaert, T., Ravichandran, K. S. (2000). Identification and Characterization of a Dimerization Domain in CED-6, an Adapter Protein Involved in Engulfment of Apoptotic Cells. J. Biol. Chem. 275: 9542-9549 [Abstract] [Full Text]  
  • Rohrschneider, L. R., Fuller, J. F., Wolf, I., Liu, Y., Lucas, D. M. (2000). Structure, function, and biology of SHIP proteins. Genes Dev. 14: 505-520 [Full Text]  
  • Dho, S. E., French, M. B., Woods, S. A., McGlade, C. J. (1999). Characterization of Four Mammalian Numb Protein Isoforms. IDENTIFICATION OF CYTOPLASMIC AND MEMBRANE-ASSOCIATED VARIANTS OF THE PHOSPHOTYROSINE BINDING DOMAIN. J. Biol. Chem. 274: 33097-33104 [Abstract] [Full Text]  
  • Rice, D. S., Curran, T. (1999). Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS. Genes Dev. 13: 2758-2773 [Full Text]  
  • Homayouni, R., Rice, D. S., Sheldon, M., Curran, T. (1999). Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1. J. Neurosci. 19: 7507-7515 [Abstract] [Full Text]  
  • Giallourakis, C., Kashiwada, M., Pan, P.-Y., Danial, N., Jiang, H., Cambier, J., Coggeshall, K. M., Rothman, P. (2000). Positive Regulation of Interleukin-4-mediated Proliferation by the SH2-containing Inositol-5'-phosphatase. J. Biol. Chem. 275: 29275-29282 [Abstract] [Full Text]  
  • March, M. E., Lucas, D. M., Aman, M. J., Ravichandran, K. S. (2000). p135 Src Homology 2 Domain-containing Inositol 5'-Phosphatase (SHIPbeta ) Isoform Can Substitute for p145 SHIP in Fcgamma RIIB1-mediated Inhibitory Signaling in B Cells. J. Biol. Chem. 275: 29960-29967 [Abstract] [Full Text]  
  • Stockinger, W., Brandes, C., Fasching, D., Hermann, M., Gotthardt, M., Herz, J., Schneider, W. J., Nimpf, J. (2000). The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2. J. Biol. Chem. 275: 25625-25632 [Abstract] [Full Text]  
  • Hembrough, T. A., Ruiz, J. F., Papathanassiu, A. E., Green, S. J., Strickland, D. K. (2001). Tissue Factor Pathway Inhibitor Inhibits Endothelial Cell Proliferation via Association with the Very Low Density Lipoprotein Receptor. J. Biol. Chem. 276: 12241-12248 [Abstract] [Full Text]  
  • Barnes, H., Larsen, B., Tyers, M., van der Geer, P. (2001). Tyrosine-phosphorylated Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Associates with the Adaptor Protein SHC in SRC-transformed Cells. J. Biol. Chem. 276: 19119-19125 [Abstract] [Full Text]  
  • Zambrano, N., Bruni, P., Minopoli, G., Mosca, R., Molino, D., Russo, C., Schettini, G., Sudol, M., Russo, T. (2001). The beta -Amyloid Precursor Protein APP Is Tyrosine-phosphorylated in Cells Expressing a Constitutively Active Form of the Abl Protoncogene. J. Biol. Chem. 276: 19787-19792 [Abstract] [Full Text]  
  • Keshvara, L., Benhayon, D., Magdaleno, S., Curran, T. (2001). Identification of Reelin-induced Sites of Tyrosyl Phosphorylation on Disabled 1. J. Biol. Chem. 276: 16008-16014 [Abstract] [Full Text]  
  • Li, Y., Lu, W., Marzolo, M. P., Bu, G. (2001). Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by Their Distinct Endocytosis Rates. J. Biol. Chem. 276: 18000-18006 [Abstract] [Full Text]  
  • Brandes, C., Kahr, L., Stockinger, W., Hiesberger, T., Schneider, W. J., Nimpf, J. (2001). Alternative Splicing in the Ligand Binding Domain of Mouse ApoE Receptor-2 Produces Receptor Variants Binding Reelin but Not alpha 2-Macroglobulin. J. Biol. Chem. 276: 22160-22169 [Abstract] [Full Text]  
  • Segarini, P. R., Nesbitt, J. E., Li, D., Hays, L. G., Yates, J. R. III, Carmichael, D. F. (2001). The Low Density Lipoprotein Receptor-related Protein/alpha 2-Macroglobulin Receptor Is a Receptor for Connective Tissue Growth Factor. J. Biol. Chem. 276: 40659-40667 [Abstract] [Full Text]  
  • Scheinfeld, M. H., Roncarati, R., Vito, P., Lopez, P. A., Abdallah, M., D'Adamio, L. (2002). Jun NH2-terminal Kinase (JNK) Interacting Protein 1 (JIP1) Binds the Cytoplasmic Domain of the Alzheimer's beta -Amyloid Precursor Protein (APP). J. Biol. Chem. 277: 3767-3775 [Abstract] [Full Text]  
  • Rodriguez, M. A., Pesold, C., Liu, W. S., Kriho, V., Guidotti, A., Pappas, G. D., Costa, E. (2000). Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex. Proc. Natl. Acad. Sci. USA 97: 3550-3555 [Abstract] [Full Text]  
  • Utsunomiya-Tate, N., Kubo, K.-i., Tate, S.-i., Kainosho, M., Katayama, E., Nakajima, K., Mikoshiba, K. (2000). Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody. Proc. Natl. Acad. Sci. USA 97: 9729-9734 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»