This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Klaman, L. D.
Right arrow Articles by Kahn, B. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klaman, L. D.
Right arrow Articles by Kahn, B. B.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, August 2000, p. 5479-5489, Vol. 20, No. 15
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Lori D. Klaman,1 Olivier Boss,2 Odile D. Peroni,2 Jason K. Kim,3 Jennifer L. Martino,1 Janice M. Zabolotny,2 Nadeem Moghal,1 Margaret Lubkin,4 Young-Bum Kim,2 Arlene H. Sharpe,5 Alain Stricker-Krongrad,4 Gerald I. Shulman,3 Benjamin G. Neel,1,* and Barbara B. Kahn2,*

Cancer Biology Program, Division of Hematology-Oncology,1 and Division of Endocrinology,2 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, and Division of Immunology, Brigham and Women's Hospital,5 Boston, Massachusetts 02215; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 065363; and Metabolic Diseases Physiology, Millennium Pharmaceuticals, Cambridge, Massachusetts 021394

Received 15 March 2000/Accepted 24 April 2000

Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase that has been implicated in the regulation of insulin action, as well as in other signal transduction pathways. To investigate the role of PTP-1B in vivo, we generated homozygotic PTP-1B-null mice by targeted gene disruption. PTP-1B-deficient mice have remarkably low adiposity and are protected from diet-induced obesity. Decreased adiposity is due to a marked reduction in fat cell mass without a decrease in adipocyte number. Leanness in PTP-1B-deficient mice is accompanied by increased basal metabolic rate and total energy expenditure, without marked alteration of uncoupling protein mRNA expression. In addition, insulin-stimulated whole-body glucose disposal is enhanced significantly in PTP-1B-deficient animals, as shown by hyperinsulinemic-euglycemic clamp studies. Remarkably, increased insulin sensitivity in PTP-1B-deficient mice is tissue specific, as insulin-stimulated glucose uptake is elevated in skeletal muscle, whereas adipose tissue is unaffected. Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo.

* Corresponding author. Mailing address for Benjamin G. Neel: Cancer Biology Program, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215. Phone: (617) 667-2823. Fax: (617) 667-0610. E-mail: bneel{at}caregroup.harvard.edu. Mailing address for Barbara B. Kahn: Diabetes Unit, Beth Israel Deaconess Medical Center, 99 Brookline Ave., Boston, MA 02215. Phone: (617) 667-5422. Fax: (617) 667-2927.

Molecular and Cellular Biology, August 2000, p. 5479-5489, Vol. 20, No. 15
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Soulsby, M., Bennett, A. M. (2009). Physiological Signaling Specificity by Protein Tyrosine Phosphatases. Physiology 24: 281-289 [Abstract] [Full Text]  
  • Ugi, S., Shi, K., Nishio, Y., Shimizu, S., Guo, B., Sekine, O., Ikeda, K., Egawa, K., Yoshizaki, T., Nagai, Y., Koya, D., Takada, T., Torii, R., Kimura, H., Kashiwagi, A., Maegawa, H. (2009). Membrane Localization of Protein-Tyrosine Phosphatase 1B is Essential for its Activation of Sterol Regulatory Element-Binding Protein-1 Gene Expression and Consequent Hypertriglyceridaemia. J Biochem 146: 541-547 [Abstract] [Full Text]  
  • Fernandez-Veledo, S., Vila-Bedmar, R., Nieto-Vazquez, I., Lorenzo, M. (2009). c-Jun N-Terminal Kinase 1/2 Activation by Tumor Necrosis Factor-{alpha} Induces Insulin Resistance In Human Visceral But Not Subcutaneous Adipocytes: Reversal by Liver X Receptor Agonists. J. Clin. Endocrinol. Metab. 94: 3583-3593 [Abstract] [Full Text]  
  • Morris, D. L., Cho, K. W., Zhou, Y., Rui, L. (2009). SH2B1 Enhances Insulin Sensitivity by Both Stimulating the Insulin Receptor and Inhibiting Tyrosine Dephosphorylation of Insulin Receptor Substrate Proteins. Diabetes 58: 2039-2047 [Abstract] [Full Text]  
  • Xue, B., Pulinilkunnil, T., Murano, I., Bence, K. K., He, H., Minokoshi, Y., Asakura, K., Lee, A., Haj, F., Furukawa, N., Catalano, K. J., Delibegovic, M., Balschi, J. A., Cinti, S., Neel, B. G., Kahn, B. B. (2009). Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues. Mol. Cell. Biol. 29: 4563-4573 [Abstract] [Full Text]  
  • Heinonen, K. M., Bourdeau, A., Doody, K. M., Tremblay, M. L. (2009). Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-{gamma} signaling. Proc. Natl. Acad. Sci. USA 106: 9368-9372 [Abstract] [Full Text]  
  • Wang, J.-F., Gong, K., Wei, D.-Q., Li, Y.-X., Chou, K.-C. (2009). Molecular dynamics studies on the interactions of PTP1B with inhibitors: from the first phosphate-binding site to the second one. Protein Eng Des Sel 22: 349-355 [Abstract] [Full Text]  
  • Arias-Romero, L. E., Saha, S., Villamar-Cruz, O., Yip, S.-C., Ethier, S. P., Zhang, Z.-Y., Chernoff, J. (2009). Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells. Cancer Res. 69: 4582-4588 [Abstract] [Full Text]  
  • Abella, J. V., Park, M. (2009). Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases. Am. J. Physiol. Endocrinol. Metab. 296: E973-E984 [Abstract] [Full Text]  
  • Swarbrick, M. M., Havel, P. J., Levin, A. A., Bremer, A. A., Stanhope, K. L., Butler, M., Booten, S. L., Graham, J. L., McKay, R. A., Murray, S. F., Watts, L. M., Monia, B. P., Bhanot, S. (2009). Inhibition of Protein Tyrosine Phosphatase-1B with Antisense Oligonucleotides Improves Insulin Sensitivity and Increases Adiponectin Concentrations in Monkeys. Endocrinology 150: 1670-1679 [Abstract] [Full Text]  
  • Rajala, R. V. S., Wiskur, B., Tanito, M., Callegan, M., Rajala, A. (2009). Diabetes Reduces Autophosphorylation of Retinal Insulin Receptor and Increases Protein-Tyrosine Phosphatase-1B Activity. IOVS 50: 1033-1040 [Abstract] [Full Text]  
  • Benomar, Y., Berthou, F., Vacher, C.-M., Bailleux, V., Gertler, A., Djiane, J., Taouis, M. (2009). Leptin But Not Ciliary Neurotrophic Factor (CNTF) Induces Phosphotyrosine Phosphatase-1B Expression in Human Neuronal Cells (SH-SY5Y): Putative Explanation of CNTF Efficacy in Leptin-Resistant State. Endocrinology 150: 1182-1191 [Abstract] [Full Text]  
  • Delibegovic, M., Zimmer, D., Kauffman, C., Rak, K., Hong, E.-G., Cho, Y.-R., Kim, J. K., Kahn, B. B., Neel, B. G., Bence, K. K. (2009). Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress. Diabetes 58: 590-599 [Abstract] [Full Text]  
  • White, C. L., Whittington, A., Barnes, M. J., Wang, Z., Bray, G. A., Morrison, C. D. (2009). HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am. J. Physiol. Endocrinol. Metab. 296: E291-E299 [Abstract] [Full Text]  
  • Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., Rudich, A. (2009). Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species. Physiol. Rev. 89: 27-71 [Abstract] [Full Text]  
  • Sangwan, V., Paliouras, G. N., Abella, J. V., Dube, N., Monast, A., Tremblay, M. L., Park, M. (2008). Regulation of the Met Receptor-tyrosine Kinase by the Protein-tyrosine Phosphatase 1B and T-cell Phosphatase. J. Biol. Chem. 283: 34374-34383 [Abstract] [Full Text]  
  • Mueller, A. S., Klomann, S. D., Wolf, N. M., Schneider, S., Schmidt, R., Spielmann, J., Stangl, G., Eder, K., Pallauf, J. (2008). Redox Regulation of Protein Tyrosine Phosphatase 1B by Manipulation of Dietary Selenium Affects the Triglyceride Concentration in Rat Liver. J. Nutr. 138: 2328-2336 [Abstract] [Full Text]  
  • Nieto-Vazquez, I., Fernandez-Veledo, S., de Alvaro, C., Lorenzo, M. (2008). Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle. Diabetes 57: 3211-3221 [Abstract] [Full Text]  
  • Venkatesan, B., Ghosh-Choudhury, N., Das, F., Mahimainathan, L., Kamat, A., Kasinath, B. S., Abboud, H. E., Choudhury, G. G. (2008). Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B. FASEB J. 22: 3469-3482 [Abstract] [Full Text]  
  • Mertins, P., Eberl, H. C., Renkawitz, J., Olsen, J. V., Tremblay, M. L., Mann, M., Ullrich, A., Daub, H. (2008). Investigation of Protein-tyrosine Phosphatase 1B Function by Quantitative Proteomics. Mol. Cell. Proteomics 7: 1763-1777 [Abstract] [Full Text]  
  • Picardi, P. K., Calegari, V. C., de Oliveira Prada, P., Contin Moraes, J., Araujo, E., Gomes Marcondes, M. C. C., Ueno, M., Carvalheira, J. B. C., Velloso, L. A., Abdalla Saad, M. J. (2008). Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats. Endocrinology 149: 3870-3880 [Abstract] [Full Text]  
  • Gonzalez-Rodriguez, A., Nevado, C., Escriva, F., Sesti, G., Rondinone, C. M., Benito, M., Valverde, A. M. (2008). PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G338-G347 [Abstract] [Full Text]  
  • Rinna, A., Forman, H. J. (2008). SHP-1 Inhibition by 4-Hydroxynonenal Activates Jun N-Terminal Kinase and Glutamate Cysteine Ligase. Am. J. Respir. Cell Mol. Bio. 39: 97-104 [Abstract] [Full Text]  
  • Carre, N., Cauzac, M., Girard, J., Burnol, A.-F. (2008). Dual Effect of the Adapter Growth Factor Receptor-Bound Protein 14 (Grb14) on Insulin Action in Primary Hepatocytes. Endocrinology 149: 3109-3117 [Abstract] [Full Text]  
  • Zabolotny, J. M., Kim, Y.-B., Welsh, L. A., Kershaw, E. E., Neel, B. G., Kahn, B. B. (2008). Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo. J. Biol. Chem. 283: 14230-14241 [Abstract] [Full Text]  
  • Nakamura, Y., Patrushev, N., Inomata, H., Mehta, D., Urao, N., Kim, H. W., Razvi, M., Kini, V., Mahadev, K., Goldstein, B. J., McKinney, R., Fukai, T., Ushio-Fukai, M. (2008). Role of Protein Tyrosine Phosphatase 1B in Vascular Endothelial Growth Factor Signaling and Cell-Cell Adhesions in Endothelial Cells. Circ. Res. 102: 1182-1191 [Abstract] [Full Text]  
  • Lorenzo, M., Fernandez-Veledo, S., Vila-Bedmar, R., Garcia-Guerra, L., De Alvaro, C., Nieto-Vazquez, I. (2008). Insulin resistance induced by tumor necrosis factor-{alpha} in myocytes and brown adipocytes. J ANIM SCI 86: E94-E104 [Abstract] [Full Text]  
  • Metlakunta, A. S., Sahu, M., Sahu, A. (2008). Hypothalamic Phosphatidylinositol 3-Kinase Pathway of Leptin Signaling Is Impaired during the Development of Diet-Induced Obesity in FVB/N Mice. Endocrinology 149: 1121-1128 [Abstract] [Full Text]  
  • Kraut-Cohen, J., Muller, W. J., Elson, A. (2008). Protein-tyrosine Phosphatase {epsilon} Regulates Shc Signaling in a Kinase-specific Manner: INCREASING COHERENCE IN TYROSINE PHOSPHATASE SIGNALING. J. Biol. Chem. 283: 4612-4621 [Abstract] [Full Text]  
  • Aga-Mizrachi, S., Brutman-Barazani, T., Jacob, A. I., Bak, A., Elson, A., Sampson, S. R. (2008). Cytosolic Protein Tyrosine Phosphatase-{epsilon} Is a Negative Regulator of Insulin Signaling in Skeletal Muscle. Endocrinology 149: 605-614 [Abstract] [Full Text]  
  • Pilecka, I., Patrignani, C., Pescini, R., Curchod, M.-L., Perrin, D., Xue, Y., Yasenchak, J., Clark, A., Magnone, M. C., Zaratin, P., Valenzuela, D., Rommel, C., van Huijsduijnen, R. H. (2007). Protein-tyrosine Phosphatase H1 Controls Growth Hormone Receptor Signaling and Systemic Growth. J. Biol. Chem. 282: 35405-35415 [Abstract] [Full Text]  
  • Delibegovic, M., Bence, K. K., Mody, N., Hong, E.-G., Ko, H. J., Kim, J. K., Kahn, B. B., Neel, B. G. (2007). Improved Glucose Homeostasis in Mice with Muscle-Specific Deletion of Protein-Tyrosine Phosphatase 1B. Mol. Cell. Biol. 27: 7727-7734 [Abstract] [Full Text]  
  • Ruffolo, S. C., Forsell, P. K. A., Yuan, X., Desmarais, S., Himms-Hagen, J., Cromlish, W., Wong, K. K., Kennedy, B. P. (2007). Basal Activation of p70S6K Results in Adipose-specific Insulin Resistance in Protein-tyrosine Phosphatase 1B / Mice. J. Biol. Chem. 282: 30423-30433 [Abstract] [Full Text]  
  • Yang, R., Barouch, L. A. (2007). Leptin Signaling and Obesity: Cardiovascular Consequences. Circ. Res. 101: 545-559 [Abstract] [Full Text]  
  • Kuchay, S. M., Kim, N., Grunz, E. A., Fay, W. P., Chishti, A. H. (2007). Double Knockouts Reveal that Protein Tyrosine Phosphatase 1B Is a Physiological Target of Calpain-1 in Platelets. Mol. Cell. Biol. 27: 6038-6052 [Abstract] [Full Text]  
  • Xue, B., Kim, Y.-B., Lee, A., Toschi, E., Bonner-Weir, S., Kahn, C. R., Neel, B. G., Kahn, B. B. (2007). Protein-tyrosine Phosphatase 1B Deficiency Reduces Insulin Resistance and the Diabetic Phenotype in Mice with Polygenic Insulin Resistance. J. Biol. Chem. 282: 23829-23840 [Abstract] [Full Text]  
  • Smith, F. M., Holt, L. J., Garfield, A. S., Charalambous, M., Koumanov, F., Perry, M., Bazzani, R., Sheardown, S. A., Hegarty, B. D., Lyons, R. J., Cooney, G. J., Daly, R. J., Ward, A. (2007). Mice with a Disruption of the Imprinted Grb10 Gene Exhibit Altered Body Composition, Glucose Homeostasis, and Insulin Signaling during Postnatal Life. Mol. Cell. Biol. 27: 5871-5886 [Abstract] [Full Text]  
  • Bose, S., Farah, M A., Jung, H.-C., Lee, J.-H., Kim, Y. (2007). Molecular mechanism of bis(maltolato)oxovanadium(IV)-induced insulin signaling in 3T3-L1 and IM9 cells: impact of dexamethasone. J Mol Endocrinol 38: 627-649 [Abstract] [Full Text]  
  • Pandey, S. K., Yu, X. X., Watts, L. M., Michael, M. D., Sloop, K. W., Rivard, A. R., Leedom, T. A., Manchem, V. P., Samadzadeh, L., McKay, R. A., Monia, B. P., Bhanot, S. (2007). Reduction of Low Molecular Weight Protein-tyrosine Phosphatase Expression Improves Hyperglycemia and Insulin Sensitivity in Obese Mice. J. Biol. Chem. 282: 14291-14299 [Abstract] [Full Text]  
  • Prudente, S., Flex, E., Morini, E., Turchi, F., Capponi, D., De Cosmo, S., Tassi, V., Guida, V., Avogaro, A., Folli, F., Maiani, F., Frittitta, L., Dallapiccola, B., Trischitta, V. (2007). A Functional Variant of the Adipocyte Glycerol Channel Aquaporin 7 Gene Is Associated With Obesity and Related Metabolic Abnormalities. Diabetes 56: 1468-1474 [Abstract] [Full Text]  
  • Katz, A. (2007). Modulation of glucose transport in skeletal muscle by reactive oxygen species. J. Appl. Physiol. 102: 1671-1676 [Abstract] [Full Text]  
  • Bentires-Alj, M., Neel, B. G. (2007). Protein-Tyrosine Phosphatase 1B Is Required for HER2/Neu-Induced Breast Cancer. Cancer Res. 67: 2420-2424 [Abstract] [Full Text]  
  • Picha, K. M., Patel, S. S., Mandiyan, S., Koehn, J., Wennogle, L. P. (2007). The Role of the C-terminal Domain of Protein Tyrosine Phosphatase-1B in Phosphatase Activity and Substrate Binding. J. Biol. Chem. 282: 2911-2917 [Abstract] [Full Text]  
  • Nieto-Vazquez, I., Fernandez-Veledo, S., de Alvaro, C., Rondinone, C. M., Valverde, A. M., Lorenzo, M. (2007). Protein-Tyrosine Phosphatase 1B-Deficient Myocytes Show Increased Insulin Sensitivity and Protection Against Tumor Necrosis Factor-{alpha}-Induced Insulin Resistance. Diabetes 56: 404-413 [Abstract] [Full Text]  
  • Gonzalez-Rodriguez, A., Clampit, J. E., Escribano, O., Benito, M., Rondinone, C. M., Valverde, A. M. (2007). Developmental Switch from Prolonged Insulin Action to Increased Insulin Sensitivity in Protein Tyrosine Phosphatase 1B-Deficient Hepatocytes. Endocrinology 148: 594-608 [Abstract] [Full Text]  
  • Morrison, C. D., White, C. L., Wang, Z., Lee, S.-Y., Lawrence, D. S., Cefalu, W. T., Zhang, Z.-Y., Gettys, T. W. (2007). Increased Hypothalamic Protein Tyrosine Phosphatase 1B Contributes to Leptin Resistance with Age. Endocrinology 148: 433-440 [Abstract] [Full Text]  
  • Ala, P. J., Gonneville, L., Hillman, M., Becker-Pasha, M., Yue, E. W., Douty, B., Wayland, B., Polam, P., Crawley, M. L., McLaughlin, E., Sparks, R. B., Glass, B., Takvorian, A., Combs, A. P., Burn, T. C., Hollis, G. F., Wynn, R. (2006). Structural Insights into the Design of Nonpeptidic Isothiazolidinone-containing Inhibitors of Protein-tyrosine Phosphatase 1B. J. Biol. Chem. 281: 38013-38021 [Abstract] [Full Text]  
  • Vercauteren, M., Remy, E., Devaux, C., Dautreaux, B., Henry, J.-P., Bauer, F., Mulder, P., Hooft van Huijsduijnen, R., Bombrun, A., Thuillez, C., Richard, V. (2006). Improvement of Peripheral Endothelial Dysfunction by Protein Tyrosine Phosphatase Inhibitors in Heart Failure. Circulation 114: 2498-2507 [Abstract] [Full Text]  
  • Foster-Schubert, K. E., Cummings, D. E. (2006). Emerging Therapeutic Strategies for Obesity. Endocr. Rev. 27: 779-793 [Abstract] [Full Text]  
  • Perrin, D., Fremaux, C., Besson, D., Sauer, W. H., Scheer, A. (2006). A Microfluidics-Based Mobility Shift Assay to Discover New Tyrosine Phosphatase Inhibitors. J Biomol Screen 11: 996-1004 [Abstract]  
  • Molero, J. C., Turner, N., Thien, C. B.F., Langdon, W. Y., James, D. E., Cooney, G. J. (2006). Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action. Diabetes 55: 3411-3417 [Abstract] [Full Text]  
  • Ala, P. J., Gonneville, L., Hillman, M. C., Becker-Pasha, M., Wei, M., Reid, B. G., Klabe, R., Yue, E. W., Wayland, B., Douty, B., Polam, P., Wasserman, Z., Bower, M., Combs, A. P., Burn, T. C., Hollis, G. F., Wynn, R. (2006). Structural Basis for Inhibition of Protein-tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics. J. Biol. Chem. 281: 32784-32795 [Abstract] [Full Text]  
  • Tiran, Z., Peretz, A., Sines, T., Shinder, V., Sap, J., Attali, B., Elson, A. (2006). Tyrosine Phosphatases {varepsilon} and {alpha} Perform Specific and Overlapping Functions in Regulation of Voltage-gated Potassium Channels in Schwann Cells. Mol. Biol. Cell 17: 4330-4342 [Abstract] [Full Text]  
  • Pilch, P. F., Bergenhem, N. (2006). Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes. Mol. Pharmacol. 70: 779-785 [Abstract] [Full Text]  
  • Tups, A., Helwig, M., Stohr, S., Barrett, P., Mercer, J. G., Klingenspor, M. (2006). Photoperiodic regulation of insulin receptor mRNA and intracellular insulin signaling in the arcuate nucleus of the Siberian hamster, Phodopus sungorus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291: R643-R650 [Abstract] [Full Text]  
  • Nigorikawa, K., Yoshikawa, K., Sasaki, T., Iida, E., Tsukamoto, M., Murakami, H., Maehama, T., Hazeki, K., Hazeki, O. (2006). A Naphthoquinone Derivative, Shikonin, Has Insulin-Like Actions by Inhibiting Both Phosphatase and Tensin Homolog Deleted on Chromosome 10 and Tyrosine Phosphatases. Mol. Pharmacol. 70: 1143-1149 [Abstract] [Full Text]  
  • Martin, T. L., Alquier, T., Asakura, K., Furukawa, N., Preitner, F., Kahn, B. B. (2006). Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle. J. Biol. Chem. 281: 18933-18941 [Abstract] [Full Text]  
  • Silva, J. E. (2006). Thermogenic Mechanisms and Their Hormonal Regulation. Physiol. Rev. 86: 435-464 [Abstract] [Full Text]  
  • Hernandez, M. V., Sala, M. G. D., Balsamo, J., Lilien, J., Arregui, C. O. (2006). ER-bound PTP1B is targeted to newly forming cell-matrix adhesions. J. Cell Sci. 119: 1233-1243 [Abstract] [Full Text]  
  • Asante-Appiah, E., Patel, S., Desponts, C., Taylor, J. M., Lau, C., Dufresne, C., Therien, M., Friesen, R., Becker, J. W., Leblanc, Y., Kennedy, B. P., Scapin, G. (2006). Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase. J. Biol. Chem. 281: 8010-8015 [Abstract] [Full Text]  
  • Burdon, K. P., Bento, J. L., Langefeld, C. D., Campbell, J. K., Carr, J. J., Wagenknecht, L. M., Herrington, D. M., Freedman, B. I., Rich, S. S., Bowden, D. W. (2006). Association of Protein Tyrosine Phosphatase-N1 Polymorphisms With Coronary Calcified Plaque in the Diabetes Heart Study. Diabetes 55: 651-658 [Abstract] [Full Text]  
  • Molero, J. C., Waring, S. G., Cooper, A., Turner, N., Laybutt, R., Cooney, G. J., James, D. E. (2006). Casitas b-Lineage Lymphoma-Deficient Mice Are Protected Against High-Fat Diet-Induced Obesity and Insulin Resistance. Diabetes 55: 708-715 [Abstract] [Full Text]  
  • Heinonen, K. M., Dube, N., Bourdeau, A., Lapp, W. S., Tremblay, M. L. (2006). Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling. Proc. Natl. Acad. Sci. USA 103: 2776-2781 [Abstract] [Full Text]  
  • Lam, N T, Covey, S D, Lewis, J T, Oosman, S, Webber, T, Hsu, E C, Cheung, A T, Kieffer, T J (2006). Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver. J Mol Endocrinol 36: 163-174 [Abstract] [Full Text]  
  • Li, C., Baquiran, G., Gu, F., Tremblay, M. L., Fazel, A., Bergeron, J. J. M., Posner, B. I. (2006). Insulin Receptor Kinase-Associated Phosphotyrosine Phosphatases in Hepatic Endosomes: Assessing the Role of Phosphotyrosine Phosphatase-1B. Endocrinology 147: 912-918 [Abstract] [Full Text]  
  • Zhang, Z., Lin, S.-Y., Neel, B. G., Haimovich, B. (2006). Phosphorylated {alpha}-Actinin and Protein-tyrosine Phosphatase 1B Coregulate the Disassembly of the Focal Adhesion Kinase{middle dot}Src Complex and Promote Cell Migration. J. Biol. Chem. 281: 1746-1754 [Abstract] [Full Text]  
  • Sangwan, V., Paliouras, G. N., Cheng, A., Dube, N., Tremblay, M. L., Park, M. (2006). Protein-tyrosine Phosphatase 1B Deficiency Protects against Fas-induced Hepatic Failure. J. Biol. Chem. 281: 221-228 [Abstract] [Full Text]  
  • Dube, N., Bourdeau, A., Heinonen, K. M., Cheng, A., Lee Loy, A., Tremblay, M. L. (2005). Genetic Ablation of Protein Tyrosine Phosphatase 1B Accelerates Lymphomagenesis of p53-Null Mice through the Regulation of B-Cell Development. Cancer Res. 65: 10088-10095 [Abstract] [Full Text]  
  • Arias-Salgado, E. G., Haj, F., Dubois, C., Moran, B., Kasirer-Friede, A., Furie, B. C., Furie, B., Neel, B. G., Shattil, S. J. (2005). PTP-1B is an essential positive regulator of platelet integrin signaling. JCB 170: 837-845 [Abstract] [Full Text]  
  • Gavete, M. L., Martin, M. A., Alvarez, C., Escriva, F. (2005). Maternal Food Restriction Enhances Insulin-Induced GLUT-4 Translocation and Insulin Signaling Pathway in Skeletal Muscle from Suckling Rats. Endocrinology 146: 3368-3378 [Abstract] [Full Text]  
  • Liang, F., Lee, S.-Y., Liang, J., Lawrence, D. S., Zhang, Z.-Y. (2005). The Role of Protein-tyrosine Phosphatase 1B in Integrin Signaling. J. Biol. Chem. 280: 24857-24863 [Abstract] [Full Text]  
  • Kim, J. K., Kim, H.-J., Park, S.-Y., Cederberg, A., Westergren, R., Nilsson, D., Higashimori, T., Cho, Y.-R., Liu, Z.-X., Dong, J., Cline, G. W., Enerback, S., Shulman, G. I. (2005). Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance. Diabetes 54: 1657-1663 [Abstract] [Full Text]  
  • Florez, J. C., Agapakis, C. M., Burtt, N. P., Sun, M., Almgren, P., Rastam, L., Tuomi, T., Gaudet, D., Hudson, T. J., Daly, M. J., Ardlie, K. G., Hirschhorn, J. N., Groop, L., Altshuler, D. (2005). Association Testing of the Protein Tyrosine Phosphatase 1B Gene (PTPN1) With Type 2 Diabetes in 7,883 People. Diabetes 54: 1884-1891 [Abstract] [Full Text]  
  • Haj, F. G., Zabolotny, J. M., Kim, Y.-B., Kahn, B. B., Neel, B. G. (2005). Liver-specific Protein-tyrosine Phosphatase 1B (PTP1B) Re-expression Alters Glucose Homeostasis of PTP1B-/-Mice. J. Biol. Chem. 280: 15038-15046 [Abstract] [Full Text]  
  • Lund, I K, Hansen, J A, Andersen, H S, Moller, N P H, Billestrup, N (2005). Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling. J Mol Endocrinol 34: 339-351 [Abstract] [Full Text]  
  • Stoker, A. W (2005). Protein tyrosine phosphatases and signalling. J Endocrinol 185: 19-33 [Abstract] [Full Text]  
  • Dunn, S. L., Bjornholm, M., Bates, S. H., Chen, Z., Seifert, M., Myers, M. G. Jr. (2005). Feedback Inhibition of Leptin Receptor/Jak2 Signaling via Tyr1138 of the Leptin Receptor and Suppressor of Cytokine Signaling 3. Mol. Endocrinol. 19: 925-938 [Abstract] [Full Text]  
  • Carvalho-Filho, M. A., Ueno, M., Hirabara, S. M., Seabra, A. B., Carvalheira, J. B.C., de Oliveira, M. G., Velloso, L. A., Curi, R., Saad, M. J.A. (2005). S-Nitrosation of the Insulin Receptor, Insulin Receptor Substrate 1, and Protein Kinase B/Akt: A Novel Mechanism of Insulin Resistance. Diabetes 54: 959-967 [Abstract] [Full Text]  
  • Lacasa, D., Boute, N., Issad, T. (2005). Interaction of the Insulin Receptor with the Receptor-Like Protein Tyrosine Phosphatases PTP{alpha} and PTP{epsilon} in Living Cells. Mol. Pharmacol. 67: 1206-1213 [Abstract] [Full Text]  
  • Kappert, K., Peters, K. G., Bohmer, F. D., Ostman, A. (2005). Tyrosine phosphatases in vessel wall signaling. Cardiovasc Res 65: 587-598 [Abstract] [Full Text]  
  • Goldstein, B. J., Mahadev, K., Wu, X. (2005). Redox Paradox: Insulin Action Is Facilitated by Insulin-Stimulated Reactive Oxygen Species With Multiple Potential Signaling Targets. Diabetes 54: 311-321 [Abstract] [Full Text]  
  • Kump, D. S, Booth, F. W (2005). Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise. J. Physiol. 562: 829-838 [Abstract] [Full Text]  
  • Galic, S., Hauser, C., Kahn, B. B., Haj, F. G., Neel, B. G., Tonks, N. K., Tiganis, T. (2005). Coordinated Regulation of Insulin Signaling by the Protein Tyrosine Phosphatases PTP1B and TCPTP. Mol. Cell. Biol. 25: 819-829 [Abstract] [Full Text]  
  • Erbe, D. V., Wang, S., Zhang, Y.-L., Harding, K., Kung, L., Tam, M., Stolz, L., Xing, Y., Furey, S., Qadri, A., Klaman, L. D., Tobin, J. F. (2005). Ertiprotafib Improves Glycemic Control and Lowers Lipids via Multiple Mechanisms. Mol. Pharmacol. 67: 69-77 [Abstract] [Full Text]  
  • Schwartz, M. W., Niswender, K. D. (2004). Adiposity Signaling and Biological Defense Against Weight Gain: Absence of Protection or Central Hormone Resistance?. J. Clin. Endocrinol. Metab. 89: 5889-5897 [Abstract] [Full Text]  
  • Qiu, W., Avramoglu, R. K., Dube, N., Chong, T. M., Naples, M., Au, C., Sidiropoulos, K. G., Lewis, G. F., Cohn, J. S., Tremblay, M. L., Adeli, K. (2004). Hepatic PTP-1B Expression Regulates the Assembly and Secretion of Apolipoprotein B-Containing Lipoproteins: Evidence From Protein Tyrosine Phosphatase-1B Overexpression, Knockout, and RNAi Studies. Diabetes 53: 3057-3066 [Abstract] [Full Text]  
  • Gu, F., Nguyen, D. T., Stuible, M., Dube, N., Tremblay, M. L., Chevet, E. (2004). Protein-tyrosine Phosphatase 1B Potentiates IRE1 Signaling during Endoplasmic Reticulum Stress. J. Biol. Chem. 279: 49689-49693 [Abstract] [Full Text]  
  • Bento, J. L., Palmer, N. D., Mychaleckyj, J. C., Lange, L. A., Langefeld, C. D., Rich, S. S., Freedman, B. I., Bowden, D. W. (2004). Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes. Diabetes 53: 3007-3012 [Abstract] [Full Text]  
  • Palmer, N. D., Bento, J. L., Mychaleckyj, J. C., Langefeld, C. D., Campbell, J. K., Norris, J. M., Haffner, S. M., Bergman, R. N., Bowden, D. W. (2004). Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Measures of Glucose Homeostasis in Hispanic Americans: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes 53: 3013-3019 [Abstract] [Full Text]  
  • Bullen, J. W. Jr, Ziotopoulou, M., Ungsunan, L., Misra, J., Alevizos, I., Kokkotou, E., Maratos-Flier, E., Stephanopoulos, G., Mantzoros, C. S. (2004). Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am. J. Physiol. Endocrinol. Metab. 287: E662-E670 [Abstract] [Full Text]  
  • Meng, T.-C., Buckley, D. A., Galic, S., Tiganis, T., Tonks, N. K. (2004). Regulation of Insulin Signaling through Reversible Oxidation of the Protein-tyrosine Phosphatases TC45 and PTP1B. J. Biol. Chem. 279: 37716-37725 [Abstract] [Full Text]  
  • Shi, K., Egawa, K., Maegawa, H., Nakamura, T., Ugi, S., Nishio, Y., Kashiwagi, A. (2004). Protein-Tyrosine Phosphatase 1B Associates with Insulin Receptor and Negatively Regulates Insulin Signaling without Receptor Internalization. J Biochem 136: 89-96 [Abstract] [Full Text]  
  • Carr, A. N., Davis, M. G., Eby-Wilkens, E., Howard, B. W., Towne, B. A., Dufresne, T. E., Peters, K. G. (2004). Tyrosine phosphatase inhibition augments collateral blood flow in a rat model of peripheral vascular disease. Am. J. Physiol. Heart Circ. Physiol. 287: H268-H276 [Abstract] [Full Text]  
  • Lund, I. K., Andersen, H. S., Iversen, L. F., Olsen, O. H., Moller, K. B., Pedersen, A. K., Ge, Y., Holsworth, D. D., Newman, M. J., Axe, F. U., Moller, N. P. H. (2004). Structure-based Design of Selective and Potent Inhibitors of Protein-tyrosine Phosphatase {beta}. J. Biol. Chem. 279: 24226-24235 [Abstract] [Full Text]  
  • Zabolotny, J. M., Haj, F. G., Kim, Y.-B., Kim, H.-J., Shulman, G. I., Kim, J. K., Neel, B. G., Kahn, B. B. (2004). Transgenic Overexpression of Protein-tyrosine Phosphatase 1B in Muscle Causes Insulin Resistance, but Overexpression with Leukocyte Antigen-related Phosphatase Does Not Additively Impair Insulin Action. J. Biol. Chem. 279: 24844-24851 [Abstract] [Full Text]  
  • Lamia, K. A., Peroni, O. D., Kim, Y.-B., Rameh, L. E., Kahn, B. B., Cantley, L. C. (2004). Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase {beta}-/- Mice. Mol. Cell. Biol. 24: 5080-5087 [Abstract] [Full Text]  
  • Lam, N. T., Lewis, J. T., Cheung, A. T., Luk, C. T., Tse, J., Wang, J., Bryer-Ash, M., Kolls, J. K., Kieffer, T. J. (2004). Leptin Increases Hepatic Insulin Sensitivity and Protein Tyrosine Phosphatase 1B Expression. Mol. Endocrinol. 18: 1333-1345 [Abstract] [Full Text]  
  • Sahu, A. (2004). Minireview: A Hypothalamic Role in Energy Balance with Special Emphasis on Leptin. Endocrinology 145: 2613-2620 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»