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Molecular and Cellular Biology, September 2000, p. 6891-6903, Vol. 20, No. 18
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1beta -Induced Histone H4 Acetylation on Lysines 8 and 12

Kazuhiro Ito, Peter J. Barnes, and Ian M. Adcock*

Thoracic Medicine, Imperial College School of Medicine at the National Heart & Lung Institute, London SW3 6LY, United Kingdom

Received 13 December 1999/Returned for modification 2 February 2000/Accepted 30 May 2000

We have investigated the ability of dexamethasone to regulate interleukin-1beta (IL-1beta )-induced gene expression, histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity. Low concentrations of dexamethasone (10-10 M) repress IL-1beta -stimulated granulocyte-macrophage colony-stimulating factor (GM-CSF) expression and fail to stimulate secretory leukocyte proteinase inhibitor expression. Dexamethasone (10-7 M) and IL-1beta (1 ng/ml) both stimulated HAT activity but showed a different pattern of histone H4 acetylation. Dexamethasone targeted lysines K5 and K16, whereas IL-1beta targeted K8 and K12. Low concentrations of dexamethasone (10-10 M), which do not transactivate, repressed IL-1beta -stimulated K8 and K12 acetylation. Using chromatin immunoprecipitation assays, we show that dexamethasone inhibits IL-1beta -enhanced acetylated K8-associated GM-CSF promoter enrichment in a concentration-dependent manner. Neither IL-1beta nor dexamethasone elicited any GM-CSF promoter association at acetylated K5 residues. Furthermore, we show that GR acts both as a direct inhibitor of CREB binding protein (CBP)-associated HAT activity and also by recruiting HDAC2 to the p65-CBP HAT complex. This action does not involve de novo synthesis of HDAC protein or altered expression of CBP or p300/CBP-associated factor. This mechanism for glucocorticoid repression is novel and establishes that inhibition of histone acetylation is an additional level of control of inflammatory gene expression. This further suggests that pharmacological manipulation of of specific histone acetylation status is a potentially useful approach for the treatment of inflammatory diseases.

* Corresponding author. Mailing address: Thoracic Medicine, Imperial College School of Medicine at the National Heart & Lung Institute, Dovehouse St., London SW3 6LY, United Kingdom. Phone: 44 (0)171-352-8121. Fax: 44 (0)171-351-8126. E-mail: ian.adcock{at}ic.ac.uk.

Molecular and Cellular Biology, September 2000, p. 6891-6903, Vol. 20, No. 18
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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  • Cazzola, M., Dahl, R. (2004). Inhaled Combination Therapy With Long-Acting {beta}2-Agonists and Corticosteroids in Stable COPD. Chest 126: 220-237 [Abstract] [Full Text]  
  • Druesne, N., Pagniez, A., Mayeur, C., Thomas, M., Cherbuy, C., Duee, P.-H., Martel, P., Chaumontet, C. (2004). Diallyl disulfide (DADS) increases histone acetylation and p21waf1/cip1 expression in human colon tumor cell lines. Carcinogenesis 25: 1227-1236 [Abstract] [Full Text]  
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  • Nie, M., Pang, L., Inoue, H., Knox, A. J (2003). Transcriptional Regulation of Cyclooxygenase 2 by Bradykinin and Interleukin-1{beta} in Human Airway Smooth Muscle Cells: Involvement of Different Promoter Elements, Transcription Factors, and Histone H4 Acetylation. Mol. Cell. Biol. 23: 9233-9244 [Abstract] [Full Text]  
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  • De Bosscher, K., Vanden Berghe, W., Haegeman, G. (2003). The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression. Endocr. Rev. 24: 488-522 [Abstract] [Full Text]  
  • Kang, J., Zhang, Y., Chen, J., Chen, H., Lin, C., Wang, Q., Ou, Y. (2003). Nickel-Induced Histone Hypoacetylation: The Role of Reactive Oxygen Species. Toxicol Sci 74: 279-286 [Abstract] [Full Text]  
  • Tan, L., Peng, H., Osaki, M., Choy, B. K., Auron, P. E., Sandell, L. J., Goldring, M. B. (2003). Egr-1 Mediates Transcriptional Repression of COL2A1 Promoter Activity by Interleukin-1beta. J. Biol. Chem. 278: 17688-17700 [Abstract] [Full Text]  
  • Barnes, P. J. (2003). Theophylline: New Perspectives for an Old Drug. Am. J. Respir. Crit. Care Med. 167: 813-818 [Full Text]  
  • Gilmour, P. S., Rahman, I., Donaldson, K., MacNee, W. (2003). Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles. Am. J. Physiol. Lung Cell. Mol. Physiol. 284: L533-L540 [Abstract] [Full Text]  
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  • Rogatsky, I., Luecke, H. F., Leitman, D. C., Yamamoto, K. R. (2002). Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc. Natl. Acad. Sci. USA 99: 16701-16706 [Abstract] [Full Text]  
  • Zhang, W., Kone, B. C. (2002). NF-kappa B inhibits transcription of the H+-K+-ATPase alpha 2-subunit gene: role of histone deacetylases. Am. J. Physiol. Renal Physiol. 283: F904-F911 [Abstract] [Full Text]  
  • Tomita, K., Caramori, G., Lim, S., Ito, K., Hanazawa, T., Oates, T., Chiselita, I., Jazrawi, E., Chung, K. F., Barnes, P. J., Adcock, I. M. (2002). Increased p21CIP1/WAF1 and B Cell Lymphoma Leukemia-xL Expression and Reduced Apoptosis in Alveolar Macrophages from Smokers. Am. J. Respir. Crit. Care Med. 166: 724-731 [Abstract] [Full Text]  
  • Ito, K., Caramori, G., Lim, S., Oates, T., Chung, K. F., Barnes, P. J., Adcock, I. M. (2002). Expression and Activity of Histone Deacetylases in Human Asthmatic Airways. Am. J. Respir. Crit. Care Med. 166: 392-396 [Abstract] [Full Text]  
  • Yu, Z., Zhang, W., Kone, B. C. (2002). Histone Deacetylases Augment Cytokine Induction of the iNOS Gene. J. Am. Soc. Nephrol. 13: 2009-2017 [Abstract] [Full Text]  
  • Gaughan, L., Logan, I. R., Cook, S., Neal, D. E., Robson, C. N. (2002). Tip60 and Histone Deacetylase 1 Regulate Androgen Receptor Activity through Changes to the Acetylation Status of the Receptor. J. Biol. Chem. 277: 25904-25913 [Abstract] [Full Text]  
  • Ito, K., Lim, S., Caramori, G., Cosio, B., Chung, K. F., Adcock, I. M., Barnes, P. J. (2002). A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc. Natl. Acad. Sci. USA 99: 8921-8926 [Abstract] [Full Text]  
  • Mizutani, T., Ito, T., Nishina, M., Yamamichi, N., Watanabe, A., Iba, H. (2002). Maintenance of Integrated Proviral Gene Expression Requires Brm, a Catalytic Subunit of SWI/SNF Complex. J. Biol. Chem. 277: 15859-15864 [Abstract] [Full Text]  
  • He, G., Margolis, D. M. (2002). Counterregulation of Chromatin Deacetylation and Histone Deacetylase Occupancy at the Integrated Promoter of Human Immunodeficiency Virus Type 1 (HIV-1) by the HIV-1 Repressor YY1 and HIV-1 Activator Tat. Mol. Cell. Biol. 22: 2965-2973 [Abstract] [Full Text]  
  • Barnes, P.J. (2002). Scientific rationale for inhaled combination therapy with long-acting {beta}2-agonists and corticosteroids. Eur Respir J 19: 182-191 [Abstract] [Full Text]  
  • Kohm, A. P., Sanders, V. M. (2001). Norepinephrine and beta 2-Adrenergic Receptor Stimulation Regulate CD4+ T and B Lymphocyte Function in Vitro and in Vivo. Pharmacol. Rev. 53: 487-525 [Abstract] [Full Text]  
  • Ashburner, B. P., Westerheide, S. D., Baldwin, A. S. Jr. (2001). The p65 (RelA) Subunit of NF-{kappa}B Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression. Mol. Cell. Biol. 21: 7065-7077 [Abstract] [Full Text]  
  • Smith, P. J., Cousins, D. J., Jee, Y.-K., Staynov, D. Z., Lee, T. H., Lavender, P. (2001). Suppression of Granulocyte-Macrophage Colony-Stimulating Factor Expression by Glucocorticoids Involves Inhibition of Enhancer Function by the Glucocorticoid Receptor Binding to Composite NF-AT/Activator Protein-1 Elements. J. Immunol. 167: 2502-2510 [Abstract] [Full Text]  
  • Barnes, P.J. (2001). Cytokine modulators as novel therapies for airway disease. Eur Respir J 18: 67S-77s [Abstract] [Full Text]  
  • Ito, K., Jazrawi, E., Cosio, B., Barnes, P. J., Adcock, I. M. (2001). p65-activated Histone Acetyltransferase Activity Is Repressed by Glucocorticoids. MIFEPRISTONE FAILS TO RECRUIT HDAC2 TO THE p65-HAT COMPLEX. J. Biol. Chem. 276: 30208-30215 [Abstract] [Full Text]  


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