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Molecular and Cellular Biology, January 2000, p. 656-660, Vol. 20, No. 2
0270-7306/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Extracellular Matrix-Associated Protein Sc1 Is Not Essential for Mouse Development

Peter J. McKinnon,1,* Susan K. McLaughlin,2 Manuela Kapsetaki,1 and Robert F. Margolskee3

Department of Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee 381051; Department of Neurobiology and Behavior, SUNY at Stony Brook, Stony Brook, New York2; and Howard Hughes Medical Institute and Department of Physiology and Biophysics, Mount Sinai Medical Center, New York, New York3

Received 23 July 1999/Returned for modification 13 September 1999/Accepted 11 October 1999

Sc1 is an extracellular matrix-associated protein whose function is unknown. During early embryonic development, Sc1 is widely expressed, and from embryonic day 12 (E12), Sc1 is expressed primarily in the developing nervous system. This switch in Sc1 expression at E12 suggests an importance for nervous-system development. To gain insight into Sc1 function, we used gene targeting to inactivate mouse Sc1. The Sc1-null mice showed no obvious deficits in any organs. These mice were born at the expected ratios, were fertile, and had no obvious histological abnormalities, and their long-term survival did not differ from littermate controls. Therefore, the function of Sc1 during development is not critical or, in its absence, is subserved by another protein.

* Corresponding author. Mailing address: Department of Genetics, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105. Phone: (901) 495 2700. Fax: (901) 526 2907. E-mail: peter.mckinnon{at}stjude.org.

Molecular and Cellular Biology, January 2000, p. 656-660, Vol. 20, No. 2
0270-7306/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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