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Molecular and Cellular Biology, August 2001, p. 5071-5081, Vol. 21, No. 15
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.15.5071-5081.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Early Expressed Clb Proteins Allow Accumulation of Mitotic Cyclin by Inactivating Proteolytic Machinery during S Phase

Foong May Yeong, Hong Hwa Lim, Ya Wang, and Uttam Surana*

Institute of Molecular and Cell Biology, Singapore 117609, Singapore

Received 2 March 2001/Returned for modification 17 April 2001/Accepted 8 May 2001

Periodic accumulation and destruction of mitotic cyclins are important for the initiation and termination of M phase. It is known that both APCCdc20 and APCHct1 collaborate to destroy mitotic cyclins during M phase. Here we show that this relationship between anaphase-promoting complex (APC) and Clb proteins is reversed in S phase such that the early Clb kinases (Clb3, Clb4, and Clb5 kinases) inactivate APCHct1 to allow Clb2 accumulation. This alternating antagonism between APC and Clb proteins during S and M phases constitutes an oscillatory system that generates undulations in the levels of mitotic cyclins.

* Corresponding author. Mailing address: Institute of Molecular and Cell Biology, 30 Medical Dr., Singapore 117609, Singapore. Phone: (65) 7743612, 8743518, or 8746680. Fax: (65) 7791117. E-mail: mcbucs{at}imcb.nus.edu.sg.

Molecular and Cellular Biology, August 2001, p. 5071-5081, Vol. 21, No. 15
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.15.5071-5081.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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