This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhou, X.-H.
Right arrow Articles by Fässler, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhou, X.-H.
Right arrow Articles by Fässler, R.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, September 2001, p. 5970-5978, Vol. 21, No. 17
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.17.5970-5978.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Neurocan Is Dispensable for Brain Development

Xiao-Hong Zhou,1 Cord Brakebusch,1 Henry Matthies,2 Toshitaka Oohashi,3 Emilio Hirsch,3 Markus Moser,4 Manfred Krug,2 Constanze I. Seidenbecher,5 Tobias M. Boeckers,5,6 Uwe Rauch,1 Reinhard Buettner,4 Eckart D. Gundelfinger,5 and Reinhard Fässler1,3,*

Department of Experimental Pathology, Lund University, 221 85 Lund, Sweden,1 and Institute for Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg,2 Max Planck Institute for Biochemistry, 82152 Martinsried,3 Institute of Pathology, University Hospital of RWTH Aachen, 52074 Aachen,4 Leibniz Institute for Neurobiology, 39118 Magdeburg,5 and AG Molecular Neurobiology, Institute for Anatomy, Westfälische Wilhelms-Universität, 48149 Münster,6 Germany

Received 23 April 2001/Accepted 30 May 2001

Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable and fertile and have no obvious deficits in reproduction and general performance. Brain anatomy, morphology, and ultrastructure are similar to those of wild-type mice. Perineuronal nets surrounding neurons appear largely normal. Mild deficits in synaptic plasticity may exist, as maintenance of late-phase hippocampal long-term potentiation is reduced. These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain.

* Corresponding author. Mailing address: Department of Experimental Pathology, Lund University, 221 85 Lund, Sweden. Phone: 46 46 173400. Fax: 46 46 158202. E-mail: Reinhard.Fassler{at}pat.lu.se.

Molecular and Cellular Biology, September 2001, p. 5970-5978, Vol. 21, No. 17
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.17.5970-5978.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Dours-Zimmermann, M. T., Maurer, K., Rauch, U., Stoffel, W., Fassler, R., Zimmermann, D. R. (2009). Versican V2 Assembles the Extracellular Matrix Surrounding the Nodes of Ranvier in the CNS. J. Neurosci. 29: 7731-7742 [Abstract] [Full Text]  
  • Quaglia, X., Beggah, A. T., Seidenbecher, C., Zurn, A. D. (2008). Delayed priming promotes CNS regeneration post-rhizotomy in Neurocan and Brevican-deficient mice. Brain 131: 240-249 [Abstract] [Full Text]  
  • Liu, B. P, Cafferty, W. B.J, Budel, S. O, Strittmatter, S. M (2006). Extracellular regulators of axonal growth in the adult central nervous system. Phil Trans R Soc B 361: 1593-1610 [Abstract] [Full Text]  
  • Spicer, A. P., Joo, A., Bowling, R. A. Jr. (2003). A Hyaluronan Binding Link Protein Gene Family Whose Members Are Physically Linked Adjacent to Chrondroitin Sulfate Proteoglycan Core Protein Genes: THE MISSING LINKS. J. Biol. Chem. 278: 21083-21091 [Abstract] [Full Text]  
  • Zhang, Y., Rauch, U., Perez, M.-T. R. (2003). Accumulation of Neurocan, a Brain Chondroitin Sulfate Proteoglycan, in Association with the Retinal Vasculature in RCS Rats. IOVS 44: 1252-1261 [Abstract] [Full Text]  
  • Franken, S., Junghans, U., Rosslenbroich, V., Baader, S. L., Hoffmann, R., Gieselmann, V., Viebahn, C., Kappler, J. (2003). Collapsin Response Mediator Proteins of Neonatal Rat Brain Interact with Chondroitin Sulfate. J. Biol. Chem. 278: 3241-3250 [Abstract] [Full Text]  
  • Brakebusch, C., Seidenbecher, C. I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., Krug, M., Bockers, T. M., Zhou, X., Kreutz, M. R., Montag, D., Gundelfinger, E. D., Fassler, R. (2002). Brevican-Deficient Mice Display Impaired Hippocampal CA1 Long-Term Potentiation but Show No Obvious Deficits in Learning and Memory. Mol. Cell. Biol. 22: 7417-7427 [Abstract] [Full Text]  
  • Evers, M. R., Salmen, B., Bukalo, O., Rollenhagen, A., Bosl, M. R., Morellini, F., Bartsch, U., Dityatev, A., Schachner, M. (2002). Impairment of L-type Ca2+ Channel-Dependent Forms of Hippocampal Synaptic Plasticity in Mice Deficient in the Extracellular Matrix Glycoprotein Tenascin-C. J. Neurosci. 22: 7177-7194 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»