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Molecular and Cellular Biology, May 2001, p. 3012-3024, Vol. 21, No. 9
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.9.3012-3024.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

AP-1 Repressor Protein JDP-2: Inhibition of UV-Mediated Apoptosis through p53 Down-Regulation

Fabrice Piu,1,2,* Ami Aronheim,1,3 Sigal Katz,3 and Michael Karin1

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, La Jolla, California 92093-06361; Acadia Pharmaceuticals Inc., San Diego, California 921212; and Department of Molecular Genetics, The B. Rappaport Faculty of Medicine, Technion, Bat Galim, Haifa 31096, Israel3

Received 12 October 2000/Returned for modification 20 November 2000/Accepted 8 February 2001

Members of the AP-1 transcription factor family, especially c-Jun and c-Fos, have long been known to mediate critical steps in the cellular response to ultraviolet (UV) irradiation. We sought to examine whether two newly discovered members of the AP-1 family, JDP-1 and JDP-2, also participate in the mammalian UV response. Here we report that JDP-2, but not JDP-1, is transiently induced upon UV challenge and that elevated levels of JDP-2 increase cell survival following UV exposure. This protective function of JDP-2 appears to be mediated through repression of p53 expression at the transcriptional level, via a conserved atypical AP-1 site in the p53 promoter.

* Corresponding author. Mailing address: Signal Transduction Group, Acadia Pharmaceuticals, Inc., 3911 Sorrento Valley Blvd., San Diego, CA 92121. Phone: (858) 558-2871. Fax: (858) 558-2872. E-mail: fpiu{at}acadia-pharm.com.

Molecular and Cellular Biology, May 2001, p. 3012-3024, Vol. 21, No. 9
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.9.3012-3024.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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