This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brakebusch, C.
Right arrow Articles by Fässler, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brakebusch, C.
Right arrow Articles by Fässler, R.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, November 2002, p. 7417-7427, Vol. 22, No. 21
0270-7306/02/$04.00+0     DOI: 10.1128/MCB.22.21.7417-7427.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Brevican-Deficient Mice Display Impaired Hippocampal CA1 Long-Term Potentiation but Show No Obvious Deficits in Learning and Memory

Cord Brakebusch,1,2 Constanze I. Seidenbecher,3 Fredrik Asztely,4 Uwe Rauch,2 Henry Matthies,3 Hannelore Meyer,1 Manfred Krug,3 Tobias M. Böckers,5 Xiaohong Zhou,2 Michael R. Kreutz,3 Dirk Montag,6 Eckart D. Gundelfinger,3 and Reinhard Fässler1,2*

Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried,1 Department of Neurochemistry and Molecular Biology,3 Neurogenetics Research Group, Leibniz Institute for Neurobiology, 39118 Magdeburg,6 Institute for Anatomy, University of Münster, 48149 Münster, Germany,5 Department of Experimental Pathology,2 Department of Neurology, Lund University Hospital, 22185 Lund, Sweden4

Received 17 April 2002/ Returned for modification 10 June 2002/ Accepted 16 July 2002

Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets. Brevican increases the invasiveness of glioma cells in vivo and has been suggested to play a role in central nervous system fiber tract development. To study the role of brevican in the development and function of the brain, we generated mice lacking a functional brevican gene. These mice are viable and fertile and have a normal life span. Brain anatomy was normal, although alterations in the expression of neurocan were detected. Perineuronal nets formed but appeared to be less prominent in mutant than in wild-type mice. Brevican-deficient mice showed significant deficits in the maintenance of hippocampal long-term potentiation (LTP). However, no obvious impairment of excitatory and inhibitory synaptic transmission was found, suggesting a complex cause for the LTP defect. Detailed behavioral analysis revealed no statistically significant deficits in learning and memory. These data indicate that brevican is not crucial for brain development but has restricted structural and functional roles.

* Corresponding author. Mailing address: Department of Molecular Medicine, Max Planck Institute of Biochemistry, Am Klopferspitz 18A, 82152 Martinsried, Germany. Phone.: 49-89-8578 2897. Fax: 49-89-8578 2422. E-mail: faessler{at}biochem.mpg.de.

Molecular and Cellular Biology, November 2002, p. 7417-7427, Vol. 22, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/MCB.22.21.7417-7427.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Dours-Zimmermann, M. T., Maurer, K., Rauch, U., Stoffel, W., Fassler, R., Zimmermann, D. R. (2009). Versican V2 Assembles the Extracellular Matrix Surrounding the Nodes of Ranvier in the CNS. J. Neurosci. 29: 7731-7742 [Abstract] [Full Text]  
  • Quaglia, X., Beggah, A. T., Seidenbecher, C., Zurn, A. D. (2008). Delayed priming promotes CNS regeneration post-rhizotomy in Neurocan and Brevican-deficient mice. Brain 131: 240-249 [Abstract] [Full Text]  
  • Hedstrom, K. L., Xu, X., Ogawa, Y., Frischknecht, R., Seidenbecher, C. I., Shrager, P., Rasband, M. N. (2007). Neurofascin assembles a specialized extracellular matrix at the axon initial segment. JCB 178: 875-886 [Abstract] [Full Text]  
  • Ida, M., Shuo, T., Hirano, K., Tokita, Y., Nakanishi, K., Matsui, F., Aono, S., Fujita, H., Fujiwara, Y., Kaji, T., Oohira, A. (2006). Identification and Functions of Chondroitin Sulfate in the Milieu of Neural Stem Cells. J. Biol. Chem. 281: 5982-5991 [Abstract] [Full Text]  
  • Corvetti, L., Rossi, F. (2005). Degradation of Chondroitin Sulfate Proteoglycans Induces Sprouting of Intact Purkinje Axons in the Cerebellum of the Adult Rat. J. Neurosci. 25: 7150-7158 [Abstract] [Full Text]  
  • Levenson, J. M., Choi, S., Lee, S.-Y., Cao, Y. A., Ahn, H. J., Worley, K. C., Pizzi, M., Liou, H.-C., Sweatt, J. D. (2004). A Bioinformatics Analysis of Memory Consolidation Reveals Involvement of the Transcription Factor c-Rel. J. Neurosci. 24: 3933-3943 [Abstract] [Full Text]  
  • LYNCH, M. A. (2004). Long-Term Potentiation and Memory. Physiol. Rev. 84: 87-136 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»