This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Montag-Sallaz, M.
Right arrow Articles by Montag, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Montag-Sallaz, M.
Right arrow Articles by Montag, D.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, November 2002, p. 7967-7981, Vol. 22, No. 22
0270-7306/02/$04.00+0     DOI: 10.1128/MCB.22.22.7967-7981.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Misguided Axonal Projections, Neural Cell Adhesion Molecule 180 mRNA Upregulation, and Altered Behavior in Mice Deficient for the Close Homolog of L1

M. Montag-Sallaz,1,2 M. Schachner,2,3 and D. Montag1,2*

Neurogenetics Research Group, Leibniz Institute for Neurobiology, D-39118 Magdeburg,1 Zentrum für Molekulare Neurobiologie, Universitäts-Krankenhaus, Eppendorf, D-20246 Hamburg, Germany,3 Department of Neurobiology, Swiss Federal Institute of Technology, Hoenggerberg, CH 8093 Zurich, Switzerland2

Received 4 April 2002/ Returned for modification 4 June 2002/ Accepted 15 August 2002

Cell recognition molecules are involved in nervous system development and participate in synaptic plasticity in the adult brain. The close homolog of L1 (CHL1), a recently identified member of the L1 family of cell adhesion molecules, is expressed by neurons and glia in the central nervous system and by Schwann cells in the peripheral nervous system in a pattern overlapping, but distinct from, the other members of the L1 family. In humans, CHL1 (also referred to as CALL) is a candidate gene for 3p- syndrome-associated mental impairment. In the present study, we generated and analyzed CHL1-deficient mice. At the morphological level, these mice showed alterations of hippocampal mossy fiber organization and of olfactory axon projections. Expression of the mRNA of the synapse-specific neural cell adhesion molecule 180 isoform was upregulated in adult CHL1-deficient mice, but the mRNA levels of several other recognition molecules were not changed. The behavior of CHL1-deficient mice in the open field, the elevated plus maze, and the Morris water maze indicated that the mutant animals reacted differently to their environment. Our data show that the permanent absence of CHL1 results in misguided axonal projections and aberrant axonal connectivity and alters the exploratory behavior in novel environments, suggesting deficits in information processing in CHL1-deficient mice.

* Corresponding author. Mailing address: Neurogenetics Research Group, Leibniz Institute for Neurobiology, D-39118 Magdeburg, Germany. Phone: 49-391-6263215. Fax: 49-391-6263252. E-mail: montag{at}ifn-magdeburg.de.

Molecular and Cellular Biology, November 2002, p. 7967-7981, Vol. 22, No. 22
0022-538X/02/$04.00+0     DOI: 10.1128/MCB.22.22.7967-7981.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kolata, S., Wu, J., Light, K., Schachner, M., Matzel, L. D. (2008). Impaired Working Memory Duration But Normal Learning Abilities Found in Mice That Are Conditionally Deficient in the Close Homolog of L1. J. Neurosci. 28: 13505-13510 [Abstract] [Full Text]  
  • Schmidt, S., Richter, M., Montag, D., Sartorius, T., Gawlik, V., Hennige, A. M., Scherneck, S., Himmelbauer, H., Lutz, S. Z., Augustin, R., Kluge, R., Ruth, P., Joost, H.-G., Schurmann, A. (2008). Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice. Am. J. Physiol. Endocrinol. Metab. 295: E1084-E1094 [Abstract] [Full Text]  
  • Batista-Brito, R., Machold, R., Klein, C., Fishell, G. (2008). Gene Expression in Cortical Interneuron Precursors is Prescient of their Mature Function. Cereb Cortex 18: 2306-2317 [Abstract] [Full Text]  
  • Wright, A. G., Demyanenko, G. P., Powell, A., Schachner, M., Enriquez-Barreto, L., Tran, T. S., Polleux, F., Maness, P. F. (2007). Close Homolog of L1 and Neuropilin 1 Mediate Guidance of Thalamocortical Axons at the Ventral Telencephalon. J. Neurosci. 27: 13667-13679 [Abstract] [Full Text]  
  • Jakovcevski, I., Wu, J., Karl, N., Leshchyns'ka, I., Sytnyk, V., Chen, J., Irintchev, A., Schachner, M. (2007). Glial Scar Expression of CHL1, the Close Homolog of the Adhesion Molecule L1, Limits Recovery after Spinal Cord Injury. J. Neurosci. 27: 7222-7233 [Abstract] [Full Text]  
  • Angata, K., Long, J. M., Bukalo, O., Lee, W., Dityatev, A., Wynshaw-Boris, A., Schachner, M., Fukuda, M., Marth, J. D. (2004). Sialyltransferase ST8Sia-II Assembles a Subset of Polysialic Acid That Directs Hippocampal Axonal Targeting and Promotes Fear Behavior. J. Biol. Chem. 279: 32603-32613 [Abstract] [Full Text]  
  • Frints, S. G. M., Marynen, P., Hartmann, D., Fryns, J.-P., Steyaert, J., Schachner, M., Rolf, B., Craessaerts, K., Snellinx, A., Hollanders, K., D'Hooge, R., De Deyn, P. P., Froyen, G. (2003). CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior. Hum Mol Genet 12: 1463-1474 [Abstract] [Full Text]  
  • Buhusi, M., Midkiff, B. R., Gates, A. M., Richter, M., Schachner, M., Maness, P. F. (2003). Close Homolog of L1 Is an Enhancer of Integrin-mediated Cell Migration. J. Biol. Chem. 278: 25024-25031 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»