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Molecular and Cellular Biology, February 2002, p. 1172-1183, Vol. 22, No. 4
0270-7306/01/$04.00+0     DOI: 10.1128/MCB.22.4.1172-1183.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Wnt/ß-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Eek-hoon Jho,1,2,{dagger} Tong Zhang,1 Claire Domon,3 Choun-Ki Joo,2 Jean-Noel Freund,3 and Frank Costantini1*

Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032,1 INSERM Unit 381, F-67200 Strasbourg, France,3 Laboratory of Ophthalmology and Visual Science, Catholic University Medical College, Seoul 137-701, Korea2

Received 17 September 2001/ Accepted 16 November 2001

Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt signaling pathway, which promote the phosphorylation and degradation of ß-catenin. While Axin is expressed ubiquitously, Axin2 mRNA was seen in a restricted pattern during mouse embryogenesis and organogenesis. Because many sites of Axin2 expression overlapped with those of several Wnt genes, we tested whether Axin2 was induced by Wnt signaling. Endogenous Axin2 mRNA and protein expression could be rapidly induced by activation of the Wnt pathway, and Axin2 reporter constructs, containing a 5.6-kb DNA fragment including the promoter and first intron, were also induced. This genomic region contains eight Tcf/LEF consensus binding sites, five of which are located within longer, highly conserved noncoding sequences. The mutation or deletion of these Tcf/LEF sites greatly diminished induction by ß-catenin, and mutation of the Tcf/LEF site T2 abolished protein binding in an electrophoretic mobility shift assay. These results strongly suggest that Axin2 is a direct target of the Wnt pathway, mediated through Tcf/LEF factors. The 5.6-kb genomic sequence was sufficient to direct the tissue-specific expression of d2EGFP in transgenic embryos, consistent with a role for the Tcf/LEF sites and surrounding conserved sequences in the in vivo expression pattern of Axin2. Our results suggest that Axin2 participates in a negative feedback loop, which could serve to limit the duration or intensity of a Wnt-initiated signal.

* Corresponding author. Mailing address: Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W. 168th St., New York, NY 10032. Phone: (212) 305-6814. Fax: (212) 923-2090. E-mail: fdc3{at}columbia.edu.

{dagger} Present address: ISO Healthcare Group, Westport, CT 06880.

Molecular and Cellular Biology, February 2002, p. 1172-1183, Vol. 22, No. 4
0022-538X/01/$04.00+0     DOI: 10.1128/MCB.22.4.1172-1183.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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  • Salisbury, T. B., Binder, A. K., Grammer, J. C., Nilson, J. H. (2007). Maximal Activity of the Luteinizing Hormone{beta}-Subunit Gene Requires {beta}-Catenin. Mol. Endocrinol. 21: 963-971 [Abstract] [Full Text]  
  • Yochum, G. S., McWeeney, S., Rajaraman, V., Cleland, R., Peters, S., Goodman, R. H. (2007). Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells. Proc. Natl. Acad. Sci. USA 104: 3324-3329 [Abstract] [Full Text]  
  • Reinhold, M. I., Naski, M. C. (2007). Direct Interactions of Runx2 and Canonical Wnt Signaling Induce FGF18. J. Biol. Chem. 282: 3653-3663 [Abstract] [Full Text]  
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  • Schneikert, J., Grohmann, A., Behrens, J. (2007). Truncated APC regulates the transcriptional activity of {beta}-catenin in a cell cycle dependent manner. Hum Mol Genet 16: 199-209 [Abstract] [Full Text]  
  • Yochum, G. S., Cleland, R., McWeeney, S., Goodman, R. H. (2007). An Antisense Transcript Induced by Wnt/beta-Catenin Signaling Decreases E2F4. J. Biol. Chem. 282: 871-878 [Abstract] [Full Text]  
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  • Dequeant, M.-L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., Pourquie, O. (2006). A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock. Science 314: 1595-1598 [Abstract] [Full Text]  
  • Peng, G., Westerfield, M. (2006). Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development 133: 3191-3200 [Abstract] [Full Text]  
  • Mou, C., Jackson, B., Schneider, P., Overbeek, P. A., Headon, D. J. (2006). Generation of the primary hair follicle pattern. Proc. Natl. Acad. Sci. USA 103: 9075-9080 [Abstract] [Full Text]  
  • Kim, S., Xu, X., Hecht, A., Boyer, T. G. (2006). Mediator Is a Transducer of Wnt/beta-Catenin Signaling. J. Biol. Chem. 281: 14066-14075 [Abstract] [Full Text]  
  • Lowy, A. M., Clements, W. M., Bishop, J., Kong, L., Bonney, T., Sisco, K., Aronow, B., Fenoglio-Preiser, C., Groden, J. (2006). {beta}-Catenin/Wnt Signaling Regulates Expression of the Membrane Type 3 Matrix Metalloproteinase in Gastric Cancer.. Cancer Res. 66: 4734-4741 [Abstract] [Full Text]  
  • Creyghton, M. P., Roel, G., Eichhorn, P. J. A., Vredeveld, L. C., Destree, O., Bernards, R. (2006). PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle. Proc. Natl. Acad. Sci. USA 103: 5397-5402 [Abstract] [Full Text]  
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  • Krieghoff, E., Behrens, J., Mayr, B. (2006). Nucleo-cytoplasmic distribution of {beta}-catenin is regulated by retention.. J. Cell Sci. 119: 1453-1463 [Abstract] [Full Text]  
  • Ayyanan, A., Civenni, G., Ciarloni, L., Morel, C., Mueller, N., Lefort, K., Mandinova, A., Raffoul, W., Fiche, M., Dotto, G. P., Brisken, C. (2006). Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc. Natl. Acad. Sci. USA 103: 3799-3804 [Abstract] [Full Text]  
  • Boerboom, D., White, L. D., Dalle, S., Courty, J., Richards, J. S. (2006). Dominant-Stable {beta}-Catenin Expression Causes Cell Fate Alterations and Wnt Signaling Antagonist Expression in a Murine Granulosa Cell Tumor Model. Cancer Res. 66: 1964-1973 [Abstract] [Full Text]  
  • Reinhold, M. I., Kapadia, R. M., Liao, Z., Naski, M. C. (2006). The Wnt-inducible Transcription Factor Twist1 Inhibits Chondrogenesis. J. Biol. Chem. 281: 1381-1388 [Abstract] [Full Text]  
  • Almeida, M., Han, L., Bellido, T., Manolagas, S. C., Kousteni, S. (2005). Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by {beta}-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT. J. Biol. Chem. 280: 41342-41351 [Abstract] [Full Text]  
  • Nakaya, M.-a., Biris, K., Tsukiyama, T., Jaime, S., Rawls, J. A., Yamaguchi, T. P. (2005). Wnt3alinks left-right determination with segmentation and anteroposterior axis elongation. Development 132: 5425-5436 [Abstract] [Full Text]  
  • Muzio, L., Soria, J.M., Pannese, M., Piccolo, S., Mallamaci, A. (2005). A Mutually Stimulating Loop Involving Emx2 and Canonical Wnt Signalling Specifically Promotes Expansion of Occipital Cortex and Hippocampus. Cereb Cortex 15: 2021-2028 [Abstract] [Full Text]  
  • Penman, G. A., Leung, L., Nathke, I. S. (2005). The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J. Cell Sci. 118: 4741-4750 [Abstract] [Full Text]  
  • Beaudoin, G. M. J. III, Sisk, J. M., Coulombe, P. A., Thompson, C. C. (2005). Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc. Natl. Acad. Sci. USA 102: 14653-14658 [Abstract] [Full Text]  
  • Stanger, B. Z., Datar, R., Murtaugh, L. C., Melton, D. A. (2005). Direct regulation of intestinal fate by Notch. Proc. Natl. Acad. Sci. USA 102: 12443-12448 [Abstract] [Full Text]  
  • Kim, K.-A., Kakitani, M., Zhao, J., Oshima, T., Tang, T., Binnerts, M., Liu, Y., Boyle, B., Park, E., Emtage, P., Funk, W. D., Tomizuka, K. (2005). Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium. Science 309: 1256-1259 [Abstract] [Full Text]  
  • Weiske, J., Huber, O. (2005). The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-{beta}-catenin-mediated transcription. J. Cell Sci. 118: 3117-3129 [Abstract] [Full Text]  
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  • Chia, I. V., Costantini, F. (2005). Mouse Axin and Axin2/Conductin Proteins Are Functionally Equivalent In Vivo. Mol. Cell. Biol. 25: 4371-4376 [Abstract] [Full Text]  
  • Tamamura, Y., Otani, T., Kanatani, N., Koyama, E., Kitagaki, J., Komori, T., Yamada, Y., Costantini, F., Wakisaka, S., Pacifici, M., Iwamoto, M., Enomoto-Iwamoto, M. (2005). Developmental Regulation of Wnt/{beta}-Catenin Signals Is Required for Growth Plate Assembly, Cartilage Integrity, and Endochondral Ossification. J. Biol. Chem. 280: 19185-19195 [Abstract] [Full Text]  
  • Gregorieff, A., Clevers, H. (2005). Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev. 19: 877-890 [Abstract] [Full Text]  
  • Yu, H.-M. I., Jerchow, B., Sheu, T.-J., Liu, B., Costantini, F., Puzas, J. E., Birchmeier, W., Hsu, W. (2005). The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development 132: 1995-2005 [Abstract] [Full Text]  
  • Bommer, G. T., Jager, C., Durr, E.-M., Baehs, S., Eichhorst, S. T., Brabletz, T., Hu, G., Frohlich, T., Arnold, G., Kress, D. C., Goke, B., Fearon, E. R., Kolligs, F. T. (2005). DRO1, a Gene Down-regulated by Oncogenes, Mediates Growth Inhibition in Colon and Pancreatic Cancer Cells. J. Biol. Chem. 280: 7962-7975 [Abstract] [Full Text]  
  • Creyghton, M. P., Roel, G., Eichhorn, P. J.A., Hijmans, E. M., Maurer, I., Destree, O., Bernards, R. (2005). PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev. 19: 376-386 [Abstract] [Full Text]  
  • Choi, J., Park, S. Y., Costantini, F., Jho, E.-h., Joo, C.-K. (2004). Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin. J. Biol. Chem. 279: 49188-49198 [Abstract] [Full Text]  
  • Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A., Nakayama, K. I. (2004). Early Embryonic Death in Mice Lacking the {beta}-Catenin-Binding Protein Duplin. Mol. Cell. Biol. 24: 8386-8394 [Abstract] [Full Text]  
  • Aulehla, A., Herrmann, B. G. (2004). Segmentation in vertebrates: clock and gradient finally joined. Genes Dev. 18: 2060-2067 [Abstract] [Full Text]  
  • Zeng, Y. A., Verheyen, E. M. (2004). Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development. Development 131: 2911-2920 [Abstract] [Full Text]  
  • Smit, L., Baas, A., Kuipers, J., Korswagen, H., van de Wetering, M., Clevers, H. (2004). Wnt Activates the Tak1/Nemo-like Kinase Pathway. J. Biol. Chem. 279: 17232-17240 [Abstract] [Full Text]  
  • He, X., Semenov, M., Tamai, K., Zeng, X. (2004). LDL receptor-related proteins 5 and 6 in Wnt/{beta}-catenin signaling: Arrows point the way. Development 131: 1663-1677 [Abstract] [Full Text]  
  • Chesire, D. R., Dunn, T. A., Ewing, C. M., Luo, J., Isaacs, W. B. (2004). Identification of Aryl Hydrocarbon Receptor as a Putative Wnt/{beta}-Catenin Pathway Target Gene in Prostate Cancer Cells. Cancer Res. 64: 2523-2533 [Abstract] [Full Text]  
  • Morkel, M., Huelsken, J., Wakamiya, M., Ding, J., van de Wetering, M., Clevers, H., Taketo, M. M., Behringer, R. R., Shen, M. M., Birchmeier, W. (2003). {beta}-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development 130: 6283-6294 [Abstract] [Full Text]  
  • Feng, Y., Lee, N., Fearon, E. R. (2003). TIP49 Regulates {beta}-Catenin-Mediated Neoplastic Transformation and T-Cell Factor Target Gene Induction via Effects on Chromatin Remodeling. Cancer Res. 63: 8726-8734 [Abstract] [Full Text]  
  • Topol, L., Jiang, X., Choi, H., Garrett-Beal, L., Carolan, P. J., Yang, Y. (2003). Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent {beta}-catenin degradation. JCB 162: 899-908 [Abstract] [Full Text]  
  • Soshnikova, N., Zechner, D., Huelsken, J., Mishina, Y., Behringer, R. R., Taketo, M. M., Crenshaw, E. B. III, Birchmeier, W. (2003). Genetic interaction between Wnt/{beta}-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev. 17: 1963-1968 [Abstract] [Full Text]  
  • Schwartz, D. R., Wu, R., Kardia, S. L. R., Levin, A. M., Huang, C.-C., Shedden, K. A., Kuick, R., Misek, D. E., Hanash, S. M., Taylor, J. M. G., Reed, H., Hendrix, N., Zhai, Y., Fearon, E. R., Cho, K. R. (2003). Novel Candidate Targets of {beta}-Catenin/T-cell Factor Signaling Identified by Gene Expression Profiling of Ovarian Endometrioid Adenocarcinomas. Cancer Res. 63: 2913-2922 [Abstract] [Full Text]  
  • Atcha, F. A., Munguia, J. E., Li, T. W. H., Hovanes, K., Waterman, M. L. (2003). A New beta -Catenin-dependent Activation Domain in T Cell Factor. J. Biol. Chem. 278: 16169-16175 [Abstract] [Full Text]  
  • Surendran, K., Simon, T. C. (2003). CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury. Am. J. Physiol. Renal Physiol. 284: F653-F662 [Abstract] [Full Text]  
  • Genter, M. B., Burman, D. M., Vijayakumar, S., Ebert, C. L., Aronow, B. J. (2002). Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Physiol. Genomics 12: 35-45 [Abstract] [Full Text]  
  • Leung, J. Y., Kolligs, F. T., Wu, R., Zhai, Y., Kuick, R., Hanash, S., Cho, K. R., Fearon, E. R. (2002). Activation of AXIN2 Expression by beta -Catenin-T Cell Factor. A FEEDBACK REPRESSOR PATHWAY REGULATING Wnt SIGNALING. J. Biol. Chem. 277: 21657-21665 [Abstract] [Full Text]  
  • Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., van de Wetering, M., Clevers, H., Schlag, P. M., Birchmeier, W., Behrens, J. (2002). Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors. Mol. Cell. Biol. 22: 1184-1193 [Abstract] [Full Text]  


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