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Molecular and Cellular Biology, January 2003, p. 272-279, Vol. 23, No. 1
0270-7306/03/$08.00+0     DOI: 10.1128/MCB.23.1.272-279.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 10 Expressed Specifically Early in Pregnancy in the Decidua Is Dispensable for Normal Murine Development

Daniela Finkenzeller,1,1 Beate Fischer,1,2 Sabine Lutz,1,3 Heinrich Schrewe,2,4 Takehiko Shimizu,2,5 and Wolfgang Zimmermann1,3*

Institute of Molecular Medicine and Cell Research, University of Freiburg,1 Department of Developmental Biology, Max-Planck Institute of Immunobiology, Freiburg,2 Tumor Immunology Laboratory, Department of Urology, University Clinic Grosshadern, Ludwig-Maximilians-University München, D-81377 Münich, Germany3

Received 4 June 2002/ Returned for modification 4 September 2002/ Accepted 25 September 2002

The carcinoembryonic antigen (CEA) family consists of a large group of evolutionarily and structurally divergent glycoproteins. The murine CEACAM9 and CEACAM11-related proteins as well as the pregnancy-specific glycoproteins (PSG) are secreted members of the CEA family which are differentially expressed in fetal trophoblast cell populations during placental development. PSG are essential for a successful pregnancy, possibly by protecting the semiallotypic fetus from the maternal immune system. In contrast, Ceacam10 mRNA, coding for a protein identical in structure with CEACAM11-related proteins, is expressed in the maternal decidua surrounding the implantation site of the conceptus only during early stages of gestation between day 6.5 and day 10.5 postcoitum. To determine its role during murine development, we inactivated Ceacam10. Ceacam10-/- mice developed, like the previously established Ceacam9-/- mice, indistinguishably from wild-type littermates with respect to sex ratio, weight gain, and fertility. However, a small but significant reduction of the litter size by 23% was observed in Ceacam10-/- matings. Furthermore, combining the Ceacam9 and Ceacam10 null alleles, both located on chromosome 7, by meiotic recombination and subsequent mating of heterozygotes carrying both knockout alleles on one chromosome yielded wild-type and double knockout offspring at the expected Mendelian ratio. Taken together, both Ceacam10 and Ceacam9, alone or in combination, are not essential for either murine placental and embryonic development or for adult life.

* Corresponding author. Mailing address: Tumor Immunology Laboratory, Department of Urology, University Clinic Grosshadern, Ludwig-Maximilians-University München, Marchioninistrasse 23, D-81377 Munich, Germany. Phone: 49 (0) 89 7095-4895. Fax: 49 (0) 89 7095-4864. E-mail: wolfgang.zimmermann{at}life.med.uni-muenchen.de.

{dagger} Present address: Genescan Europe AG, 79108 Freiburg, Germany.

{ddagger} Present address: Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany.

§ Present address: Department of Pharmaceutical Technology, Pharmaceutical Institute, University of Freiburg, Germany.

|| Present address: School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom.

# Present address: Department of Pediatric Dentistry, Nihon University, School of Dentistry at Matsudo, Chiba, Japan.

Molecular and Cellular Biology, January 2003, p. 272-279, Vol. 23, No. 1
0022-538X/03/$08.00+0     DOI: 10.1128/MCB.23.1.272-279.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wynne, F., Ball, M., McLellan, A. S, Dockery, P., Zimmermann, W., Moore, T. (2006). Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature.. Reproduction 131: 721-732 [Abstract] [Full Text]  
  • Li, S.-H., Lee, R. K.-K., Hsiao, Y.-L., Chen, Y.-H. (2005). Demonstration of a Glycoprotein Derived From the Ceacam10 Gene in Mouse Seminal Vesicle Secretions. Biol. Reprod. 73: 546-553 [Abstract] [Full Text]  
  • Comegys, M. M., Lin, S.-H., Rand, D., Britt, D., Flanagan, D., Callanan, H., Brilliant, K., Hixson, D. C. (2004). Two Variable Regions in Carcinoembryonic Antigen-related Cell Adhesion Molecule1 N-terminal Domains Located in or Next to Monoclonal Antibody and Adhesion Epitopes Show Evidence of Recombination in Rat but Not in Human. J. Biol. Chem. 279: 35063-35078 [Abstract] [Full Text]  


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