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Molecular and Cellular Biology, October 2003, p. 6936-6943, Vol. 23, No. 19
0270-7306/03/$08.00+0     DOI: 10.1128/MCB.23.19.6936-6943.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Role of Plk2 (Snk) in Mouse Development and Cell Proliferation

Sheng Ma,1 Jean Charron,2 and Raymond L. Erikson1*

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138,1 Centre de Recherche en Cancérologie de l'Université Laval, L'Hôtel-Dieu de Québec, CHUQ, Québec, Canada G1R 2J62

Received 29 May 2003/ Accepted 16 June 2003

Plk2 (Snk) is a polo-like kinase expressed at G1 in cultured cells and mainly in the hippocampal neurons in the brains of adult rodents, but its function is poorly understood. We have generated mice deficient in Plk2 by gene targeting. Although Plk2 is not required for postnatal growth, Plk2-/- embryos show retarded growth and skeletal development late in gestation. The labyrinthine zone of the placenta is diminished in Plk2-/- embryos due to decreased cell proliferation. Cultured Plk2-/- embryonic fibroblasts grow more slowly than normal cells and show delayed entry into S phase. These data suggest a role for Plk2 in the cell cycle.

* Corresponding author. Mailing address: Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave., Cambridge, MA 02138. Phone: (617) 495-5386. Fax: (617) 495-0681. E-mail: erikson{at}mcb.harvard.edu.

Molecular and Cellular Biology, October 2003, p. 6936-6943, Vol. 23, No. 19
0022-538X/03/$08.00+0     DOI: 10.1128/MCB.23.19.6936-6943.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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