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Molecular and Cellular Biology, December 2003, p. 9025-9031, Vol. 23, No. 24
0270-7306/03/$08.00+0     DOI: 10.1128/MCB.23.24.9025-9031.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

REST/NRSF-Interacting LIM Domain Protein, a Putative Nuclear Translocation Receptor

Masahito Shimojo* and Louis B. Hersh

Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky

Received 6 June 2003/ Returned for modification 21 August 2003/ Accepted 2 September 2003

The transcriptional repressor REST/NRSF (RE-1 silencing transcription factor/neuron-restrictive silencer factor) and the transcriptional regulator REST4 share an N-terminal zinc finger domain structure involved in nuclear targeting. Using this domain as bait in a yeast two-hybrid screen, a novel protein that contains three LIM domains, putative nuclear localization sequences, protein kinase A phosphorylation sites, and a CAAX prenylation motif was isolated. This protein, which is localized around the nucleus, is involved in determining the nuclear localization of REST4 and REST/NRSF. We propose the name RILP, for REST/NRSF-interacting LIM domain protein, to label this novel protein. RILP appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors.

* Corresponding author. Mailing address: Department of Molecular and Cellular Biochemistry, University of Kentucky, Chandler Medical Center, 800 Rose St., Lexington, KY 40536-0298. Phone: (859) 323-5549. Fax: (859) 323-1727. E-mail: mshim1{at}uky.edu.

Molecular and Cellular Biology, December 2003, p. 9025-9031, Vol. 23, No. 24
0022-538X/03/$08.00+0     DOI: 10.1128/MCB.23.24.9025-9031.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Shimojo, M. (2008). Huntingtin Regulates RE1-silencing Transcription Factor/Neuron-restrictive Silencer Factor (REST/NRSF) Nuclear Trafficking Indirectly through a Complex with REST/NRSF-interacting LIM Domain Protein (RILP) and Dynactin p150Glued. J. Biol. Chem. 283: 34880-34886 [Abstract] [Full Text]  
  • Donev, R. M., Gray, L. C., Sivasankar, B., Hughes, T. R., van den Berg, C. W., Morgan, B. P. (2008). Modulation of CD59 Expression by Restrictive Silencer Factor-Derived Peptides in Cancer Immunotherapy for Neuroblastoma. Cancer Res. 68: 5979-5987 [Abstract] [Full Text]  
  • Su, X., Gopalakrishnan, V., Stearns, D., Aldape, K., Lang, F. F., Fuller, G., Snyder, E., Eberhart, C. G., Majumder, S. (2006). Abnormal Expression of REST/NRSF and Myc in Neural Stem/Progenitor Cells Causes Cerebellar Tumors by Blocking Neuronal Differentiation.. Mol. Cell. Biol. 26: 1666-1678 [Abstract] [Full Text]  
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