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Molecular and Cellular Biology, January 2004, p. 270-279, Vol. 24, No. 1
0270-7306/04/$08.00+0     DOI: 10.1128/MCB.24.1.270-279.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Mouse Murr1 Gene Is Imprinted in the Adult Brain, Presumably Due to Transcriptional Interference by the Antisense-Oriented U2af1-rs1 Gene

Youdong Wang,1 Keiichiro Joh,1* Sadahiko Masuko,2 Hitomi Yatsuki,1 Hidenobu Soejima,1 Akira Nabetani,3 Colin V. Beechey,4 Satoshi Okinami,5 and Tsunehiro Mukai1

Department of Biomolecular Sciences,1 Department of Anatomy and Physiology,2 Department of Ophthalmology, Saga Medical School, Saga 849-8501,5 Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan,3 Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxon 0X11 0RD, United Kingdom4

Received 5 May 2003/ Returned for modification 10 July 2003/ Accepted 2 October 2003

The mouse Murr1 gene contains an imprinted gene, U2af1-rs1, in its first intron. U2af1-rs1 shows paternal allele-specific expression and is transcribed in the direction opposite to that of the Murr1 gene. In contrast to a previous report of biallelic expression of Murr1 in neonatal mice, we have found that the maternal allele is expressed predominantly in the adult brain and also preferentially in other adult tissues. This maternal-predominant expression is not observed in embryonic and neonatal brains. In situ hybridization experiments that used the adult brain indicated that Murr1 gene was maternally expressed in neuronal cells in all regions of the brain. We analyzed the developmental change in the expression levels of both Murr1 and U2af1-rs1 in the brain and liver, and we propose that the maternal-predominant expression of Murr1 results from transcriptional interference of the gene by U2af1-rs1 through the Murr1 promoter region.

* Corresponding author. Mailing address: Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan. Phone: 81-952-34-2262. Fax: 81-952-34-2067. E-mail: joh{at}post.saga-med.ac.jp.

Molecular and Cellular Biology, January 2004, p. 270-279, Vol. 24, No. 1
0022-538X/04/$08.00+0     DOI: 10.1128/MCB.24.1.270-279.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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