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Molecular and Cellular Biology, August 2004, p. 6635-6644, Vol. 24, No. 15
0270-7306/04/$08.00+0     DOI: 10.1128/MCB.24.15.6635-6644.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Gene Targeting Reveals a Widespread Role for the High-Mobility-Group Transcription Factor Sox11 in Tissue Remodeling

Elisabeth Sock,1 Stefanie D. Rettig,1 Janna Enderich,1 Michael R. Bösl,2 Ernst R. Tamm,3 and Michael Wegner1*

Institut für Biochemie,1 Institut für Anatomie, Universität Erlangen-Nürnberg, Erlangen,3 Max-Planck-Institut für Neurobiologie, Martinsried, Germany2

Received 10 March 2004/ Returned for modification 24 April 2004/ Accepted 11 May 2004

The high-mobility-group domain-containing transcription factor Sox11 is expressed transiently during embryonic development in many tissues that undergo inductive remodeling. Here we have analyzed the function of Sox11 by gene deletion in the mouse. Sox11-deficient mice died at birth from congenital cyanosis, likely resulting from heart defects. These included ventricular septation defects and outflow tract malformations that ranged from arterial common trunk to a condition known as double outlet right ventricle. Many other organs that normally express Sox11 also exhibited severe developmental defects. We observed various craniofacial and skeletal malformations, asplenia, and hypoplasia of the lung, stomach, and pancreas. Eyelids and the abdominal wall did not close properly in some Sox11-deficient mice. This phenotype suggests a prime function for Sox11 in tissue remodeling and identifies SOX11 as a potentially mutated gene in corresponding human malformation syndromes.

* Corresponding author. Mailing address: Institut für Biochemie, Fahrstrasse 17, D-91054 Erlangen, Germany. Phone: 49 9131 85 24620. Fax: 49 9131 85 22484. E-mail: m.wegner{at}biochem.uni-erlangen.de.

Molecular and Cellular Biology, August 2004, p. 6635-6644, Vol. 24, No. 15
0022-538X/04/$08.00+0     DOI: 10.1128/MCB.24.15.6635-6644.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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