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Molecular and Cellular Biology, January 2006, p. 489-501, Vol. 26, No. 2
0270-7306/06/$08.00+0     doi:10.1128/MCB.26.2.489-501.2006

H2A.Z Functions To Regulate Progression through the Cell Cycle{dagger}

Namrita Dhillon,1* Masaya Oki,1 Shawn J. Szyjka,2 Oscar M. Aparicio,2 and Rohinton T. Kamakaka1

Unit on Chromatin and Transcription, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892,1 Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 900892

Received 1 October 2005/ Accepted 30 October 2005

Histone H2A variants are highly conserved proteins found ubiquitously in nature and thought to perform specialized functions in the cell. Studies in yeast on the histone H2A variant H2A.Z have shown a role for this protein in transcription as well as chromosome segregation. Our studies have focused on understanding the role of H2A.Z during cell cycle progression. We found that htz1{Delta} cells were delayed in DNA replication and progression through the cell cycle. Furthermore, cells lacking H2A.Z required the S-phase checkpoint pathway for survival. We also found that H2A.Z localized to the promoters of cyclin genes, and cells lacking H2A.Z were delayed in the induction of these cyclin genes. Several different models are proposed to explain these observations.

* Corresponding author. Mailing address: NICHD/NIH, Bldg. 18T, Rm. 106, 18 Library Dr., Bethesda, MD 20892. Phone: (301) 402-8317. Fax: (301) 402-1323. E-mail: Rohinton{at}helix.nih.gov.

{dagger} Supplemental material for this article may be found at http://mcb.asm.org/.

Molecular and Cellular Biology, January 2006, p. 489-501, Vol. 26, No. 2
0022-538X/06/$08.00+0     doi:10.1128/MCB.26.2.489-501.2006




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  • Shia, W.-J., Li, B., Workman, J. L. (2006). SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae. Genes Dev. 20: 2507-2512 [Abstract] [Full Text]  
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