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Molecular and Cellular Biology, February 2007, p. 983-992, Vol. 27, No. 3
0270-7306/07/$08.00+0     doi:10.1128/MCB.01648-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Murine CXCL14 Is Dispensable for Dendritic Cell Function and Localization within Peripheral Tissues{triangledown}

Simone Meuter,1,{dagger} Patrick Schaerli,2,{dagger} Regula Stuber Roos,1 Oliver Brandau,3 Michael R. Bösl,3 Ulrich H. von Andrian,2 and Bernhard Moser1*

Institute of Cell Biology, University of Bern, 3012 Bern, Switzerland,1 Department of Pathology, Harvard Medical School, The CBR Institute for Biomedical Research, Boston, Massachusetts 02115,2 Department of Molecular Medicine, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany3

Received 4 September 2006/ Returned for modification 8 November 2006/ Accepted 13 November 2006

Dendritic cells (DCs) have long been recognized as key regulators of immune responses. However, the process of their recruitment to peripheral tissues and turnover during homeostasis remains largely unknown. The chemokine CXCL14 (BRAK) is constitutively expressed in skin and other epithelial tissues. Recently, the human chemokine was proposed to play a role in the homeostatic recruitment of macrophage and/or DC precursors toward the periphery, such as skin. Although so far no physiological function could be demonstrated for the murine CXCL14, it shows a remarkable homology to the human chemokine. In order to elucidate the in vivo role of CXCL14, we generated a mouse defective for this chemokine. We studied various components of the immune system with emphasis on monocytes/macrophages and DC/Langerhans cell (LC) populations in different tissues during steady state but did not find a significant difference between knockout (CXCL14–/–) and control mice. Functionally, LCs were able to become activated, to migrate out of skin, and to elicit a delayed type of hypersensitivity reaction. Overall, our data indicate that murine CXCL14 is dispensable for the homeostatic recruitment of antigen-presenting cells toward the periphery and for LC functionality.

* Corresponding author. Present address: Department of Medical Biochemistry and Immunology, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom. Phone: 44 29 20742799. Fax: 44 29 20744905. E-mail: moserb{at}cf.ac.uk.

{triangledown} Published ahead of print on 27 November 2006.

{dagger} S.M and P.S. contributed equally to this work.

Molecular and Cellular Biology, February 2007, p. 983-992, Vol. 27, No. 3
0270-7306/07/$08.00+0     doi:10.1128/MCB.01648-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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