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Molecular and Cellular Biology, February 2007, p. 1321-1333, Vol. 27, No. 4
0270-7306/07/$08.00+0     doi:10.1128/MCB.01280-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Suppression of ß-Amyloid Precursor Protein Signaling into the Nucleus by Estrogens Mediated through Complex Formation between the Estrogen Receptor and Fe65{triangledown}

Junying Bao,1,3 Chuanhai Cao,2 Xiaohui Zhang,1,3 Feng Jiang,1,3,{dagger} Santo V. Nicosia,1,3 and Wenlong Bai1,3*

Departments of Pathology and of Cell Biology and Molecular Oncology, USF College of Medicine,1 Programs of Molecular Oncology and Drug Discovery, H. Lee Moffitt Cancer Center, Tampa, Florida 33612-4799,3 Department of Medical Microbiology and Johnnie B. Byrd, Sr., Alzheimer's Center & Research Institute, USF College of Medicine, Tampa, Florida 33612-47992

Received 13 July 2006/ Returned for modification 15 August 2006/ Accepted 16 November 2006

The C-terminal fragment of the ß-amyloid precursor protein produced after cleavage by {gamma}-secretase, namely, APPct or AICD, has been shown to form a multimeric complex with the adaptor protein Fe65 and to regulate transcription through the recruitment of the histone acetyltransferase Tip60. The present study shows that 17ß-estradiol inhibits the transcriptional and apoptotic activities of the APPct complex by a process involving the interaction of estrogen receptor alpha (ER{alpha}) with Fe65. ER{alpha}-Fe65 complexes were detected both in vitro and in the mouse brain, and recruitment of ER{alpha} to the promoter of an APPct target gene (KAI1) was demonstrated. Our studies reveal a novel mechanism of estrogen action, which may explain the well-known neuroprotective functions of estrogens as well as the complex role of this female hormone in the pathogenesis of neuronal degeneration diseases.

* Corresponding author. Mailing address: Department of Pathology, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., MDC 11, Tampa, FL 33612-4799. Phone: (813) 974-0563. Fax: (813) 974-5536. E-mail: wbai{at}hsc.usf.edu.

{triangledown} Published ahead of print on 27 November 2006.

{dagger} Present address: Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306-4300.

Molecular and Cellular Biology, February 2007, p. 1321-1333, Vol. 27, No. 4
0270-7306/07/$08.00+0     doi:10.1128/MCB.01280-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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