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Mol Cell Biol. 1987 April; 7(4): 1541-1544

Functional simian virus 40 T antigen is expressed in hybrid cells having finite proliferative potential.

O M Pereira-Smith and J R Smith

ABSTRACT

Simian virus 40-transformed human cells fused with other independently derived simian virus 40-transformed cells and tumor-derived cells containing activated H-ras and N-ras oncogenes yielded hybrids capable of indefinite division. Fusions with various other immortal cells yielded hybrids that had limited division potential. T antigen expressed in limited-division hybrids was functional for the induction of cellular DNA synthesis.

Mol Cell Biol. 1987 April; 7(4): 1541-1544






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Copyright © 1987 by the American Society for Microbiology. All rights reserved.