This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hollis, G F Articles by Kirsch, I R Search for Related Content PubMed PubMed Citation Articles by Hollis, G F Articles by Kirsch, I R

 Previous Article  |  Next Article 

Mol Cell Biol. 1988 January; 8(1): 124-129

Complex translocation disrupts c-myc regulation in a human plasma cell myeloma.

National Cancer Institute-Navy Medical Oncology Branch, Bethesda, Maryland 20814.

ABSTRACT

A complex translocation has interrupted the third exon of the c-myc gene in human plasma cell myeloma tumor cells and a derivative cell line (NCI-H929). As a result of this rearrangement, a chimeric mRNA is expressed which commences 5' of the c-myc coding region and includes sequences introduced by the translocation event. All of the detectable c-myc-containing mRNA in the tumor and cell line was derived from this rearranged c-myc allele. This chimeric c-myc mRNA, in which most of the germ line c-myc 3' untranslated region has been replaced, was greater than sevenfold more stable than c-myc transcripts with intact 3' ends. This suggests that the 3' untranslated region may play an important role in c-myc mRNA stability.

This article has been cited by other articles:

• Dib, A., Gabrea, A., Glebov, O. K., Bergsagel, P. L., Kuehl, W. M. (2008). Characterization of MYC Translocations in Multiple Myeloma Cell Lines. J Natl Cancer Inst Monogr 2008: 25-31 [Abstract] [Full Text]  
• Lee, P.-T., Liao, P.-C., Chang, W.-C., Tseng, J. T. (2007). Epidermal Growth Factor Increases the Interaction between Nucleolin and Heterogeneous Nuclear Ribonucleoprotein K/Poly(C) Binding Protein 1 Complex to Regulate the Gastrin mRNA Turnover. Mol. Biol. Cell 18: 5004-5013 [Abstract] [Full Text]  
• Cuendet, M., Christov, K., Lantvit, D. D., Deng, Y., Hedayat, S., Helson, L., McChesney, J. D., Pezzuto, J. M. (2004). Multiple Myeloma Regression Mediated by Bruceantin. Clin. Cancer Res. 10: 1170-1179 [Abstract] [Full Text]  
• Shou, Y., Martelli, M. L., Gabrea, A., Qi, Y., Brents, L. A., Roschke, A., Dewald, G., Kirsch, I. R., Bergsagel, P. L., Kuehl, W. M. (2000). Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. Proc. Natl. Acad. Sci. USA 97: 228-233 [Abstract] [Full Text]