This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mowatt, M R Articles by Clayton, C E Search for Related Content PubMed PubMed Citation Articles by Mowatt, M R Articles by Clayton, C E

 Previous Article  |  Next Article 

Mol Cell Biol. 1988 October; 8(10): 4055-4062

Polymorphism in the procyclic acidic repetitive protein gene family of Trypanosoma brucei.

Rockefeller University, New York, New York 10021.

ABSTRACT

The expression of procyclic acidic repetitive protein (PARP) by Trypanosoma brucei is strongly induced during the transition of bloodstream form to cultured procyclic trypomastigotes in vitro. The membrane-associated protein is distinguished by a central domain consisting of tandemly repeated glutamate-proline dipeptides. The trypanosome genome contains eight PARP genes, at least four of which are expressed. A minimum of four distinct PARP mRNA species comprises two classes of PARP mRNA, based upon divergent 3' untranslated region sequences, and these mRNAs encode polypeptides that exhibited an inverse relation between molecular weight and isoelectric point. Comparative analysis of PARP gene structure indicated that these polypeptides differ by variation in size of the dipeptide repeat domain. Comparison of PARP genes and polypeptides of three independent T. brucei isolates suggested that PARP is not a homogeneous species but instead represents a family of polymorphic proteins.

This article has been cited by other articles:

• Guha-Niyogi, A., Sullivan, D. R., Turco, S. J. (2001). Glycoconjugate structures of parasitic protozoa. Glycobiology 11: 45R-59R [Abstract] [Full Text]  
• Acosta-Serrano, A., Cole, R. N., Mehlert, A., Lee, M. G.-S., Ferguson, M. A. J., Englund, P. T. (1999). The Procyclin Repertoire of Trypanosoma brucei. IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF THE GLU-PRO-RICH POLYPEPTIDES. J. Biol. Chem. 274: 29763-29771 [Abstract] [Full Text]  
• Ruepp, S., Furger, A., Kurath, U., Renggli, C. K., Hemphill, A., Brun, R., Roditi, I. (1997). Survival of Trypanosoma brucei in the Tsetse Fly Is Enhanced by the Expression of Specific Forms of Procyclin. J. Cell Biol. 137: 1369-1379 [Abstract] [Full Text]  
• Acosta-Serrano, A., Vassella, E., Liniger, M., Renggli, C. K., Brun, R., Roditi, I., Englund, P. T. (2001). The surface coat of procyclic Trypanosoma brucei: Programmed expression and proteolytic cleavage of procyclin in the tsetse fly. Proc. Natl. Acad. Sci. USA 98: 1513-1518 [Abstract] [Full Text]  
• Nagamune, K., Nozaki, T., Maeda, Y., Ohishi, K., Fukuma, T., Hara, T., Schwarz, R. T., Sutterlin, C., Brun, R., Riezman, H., Kinoshita, T. (2000). Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei. Proc. Natl. Acad. Sci. USA 97: 10336-10341 [Abstract] [Full Text]