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Mol Cell Biol. 1988 February; 8(2): 515-521

Swiveling and decatenation of replicating simian virus 40 genomes in vivo.

R M Snapka, M A Powelson and J M Strayer

Department of Radiology, Ohio State University, Columbus 43210.

ABSTRACT

We have found that type II topoisomerase inhibitors have two effects on replicating simian virus 40 genomes in vivo: production of catenated dimers and slowed replication of the last 5% of the genome. This suggests that type II topoisomerase simultaneously decatenates and facilitates replication fork movement at this stage of DNA replication. On the basis of this observation, a detailed model is proposed for the roles of topoisomerases I and II in simian virus 40 DNA replication.

Mol Cell Biol. 1988 February; 8(2): 515-521




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