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Mol. Cell. Biol. doi:10.1128/MCB.01038-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Sizn1 is a Novel Protein that Functions as a Transcriptional Coactivator of BMP Signalling

Department of Pathology and Genetics, The Children's Hospital of Philadelphia, and Pathology, University of Pennsylvania, School of Medicine

^* To whom correspondence should be addressed. Email: goldenj{at}mail.med.upenn.edu.

	Abstract

Bone morphogenic proteins (BMP) play pleotrophic roles in nervous system development and their signalling is highly regulated at virtually every step in the pathway. We have cloned a novel gene, Sizn1 (Smad Interacting ZiNc finger protein), which functions as a transcriptional co-activator of BMP signalling. It positively modulates BMP signalling by interacting with Smad family members and associating with CBP in the transcription complex. Sizn1 is expressed in the ventral embryonic forebrain where we show it contributes to BMP-dependent cholinergic neuron specific gene expression. These data indicate Sizn1 is a positive modulator of BMP signalling and provide further insight into how BMP signalling can be modulated in neuronal progenitor subsets to influence cell type specific gene expression and development.