Cover photograph (Copyright © 1999, American Society for Microbiology. All rights reserved.): In this image, intranuclear territories occupied by the methyl-CpG DNA binding protein MBD1 (green) and a kinetochore protein (red) in HeLa cells are detected by immunofluorescence. The two proteins do not colocalize, but occasional regions of overlap are visible (yellow). (See related article on page 6415.)