Cover photograph (Copyright © 2000, American Society for Microbiology. All rights reserved.): Herpes simplex virus type 1 (HSV-1) capsids bind to nuclear pore complexes (NPCs) in vitro. Rat liver nuclei were purified and incubated with isolated viral capsids in the presence of cytosol, fixed, and processed for electron microscopy. In ultrathin plastic sections, HSV-1 capsids that bound to NPCs in the nuclear membrane were easily recognized by their size (125 nm) and their sixfold symmetry. The viral DNA is still visible as the electron-dense core inside the capsids. The capsids seem to interact with cytoplasmic fibrils emanating from the cytoplasmic face of the NPCs. (See related article in July 2000, issue 13: vol. 20, p. 4922).