Cover photograph (Copyright © 2000, American Society for Microbiology. All rights reserved.): Sarcospan is an integral component of the dystrophin glycoprotein complex found in striated muscle. Mutations in components of this complex are responsible for several forms of muscular dystrophy; however, sarcospan-deficient mice do not develop a muscular dystrophy. Here hematoxylin and eosin staining of the quadriceps femoris of a sarcospan-deficient mouse demonstrates normal histological parameters. (See related article in March 2000, issue 5: vol. 20, p. 1669.)