Cover photograph (Copyright © 2002, American Society for Microbiology. All Rights Reserved.): Site-specific inhibition of Src family kinases at focal adhesions results in loss of cell-matrix adhesion. Note the round shape of green-yellow cells that express a fusion protein of the Src regulatory kinase Csk with a focal adhesion targeting sequence and green fluorescent protein - therefore, they are green. An essential role of Src family kinases in integrin adhesive functions at focal adhesions is now proposed. Red and blue colors indicate filamentous actin and the nucleus, respectively. (See related article on p. 1203.)
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