Cover photograph (Copyright © 2002, American Society for Microbiology. All Rights Reserved.): Glomerulus from a 21-month-old clusterin-deficient mouse, demonstrating expansion of the mesangium by hypocellular material with collapse of capillary lumens. These mesangial deposits consist of immune complexes arranged in a tubulofibillary pattern by electron microscopy (periodic acid-Schiff staining). Magnification, x400. (See related article on p. 1893.)