Cover photograph (Copyright © 2002, American Society for Microbiology. All Rights Reserved.): Ectopic expression of transcription factor DREF (for DNA replication-related element-binding factor) in Drosophila melanogaster imaginal discs induces DNA synthesis, apoptosis, and unusual morphogenesis and results in a severe rough eye phenotype. A transmission electron micrograph of an adult compound eye from a wild-type fly is shown. (See related article in November 2001, issue 21: vol. 21, p. 7231-7242.)