Cover photograph (Copyright © 2003, American Society for Microbiology. All Rights Reserved.): Distribution of the Drosophila transcriptional adaptors dAda2a (red) and dAda3 (green) on polytene chromosomes from salivary glands of third-instar larvae. Shown is the tip of the X chromosome. The DNA is counterstained with 4-6-diamidino-2-phenylindole dihydrochloride (blue). Overlap of green and red stains appears as yellow, yellow-green, and orange. dAda2a is highly enriched in developmental chromosome puffs, which represent RNA polymerase II-dependent loci. dAda3, which is strictly associated with dGcn5-containing histone acetyltransferase complexes, is far less abundant in these regions. This supports the notion that dAda2a functions in dGcn5-independent transcription-linked multiprotein complexes (See related article in May 2003, issue 9; vol. 23, p. 3305.)