Cover photograph (Copyright © 2003, American Society for Microbiology. All Rights Reserved.): HPGI mutation sites and predicted tertiary structure of the Rsp5 HECT domain. The predicted α-helixes and β-sheets are shown in red and blue, respectively. The HPGI mutation and some known rsp5 mutation sites are shown in yellow. The ubiquitin-bound E2 enzyme(s) is assumed to have access to the HECT domain from the direction shown in orange (See related article on p.7566.)