Cover photograph (Copyright © 2003, American Society for Microbiology. All Rights Reserved.): Craniofacial abnormalities present in a chromosome-engineered mouse [Df(11)17/+] model for Smith-Magenis syndrome (left) compared to a wild-type littermate (right). Note the position of the snout and the broad distance between the eyes (hypertelorism) of the mutant mouse. (See related article in May 2003, issue 10; vol. 23, p. 3646.)