Cover photograph (Copyright © 2004, American Society for Microbiology. All Rights Reserved.): Distribution of phosphatidylinositol 4,5-bisphosphate, labeled with transiently expressed fluorescent construct EGFP/PLC1-PH, is shown in false color on the plasma membranes of two contacting 3T3-L1 adipocytes. The three-dimensional cell is shown in a tilted view, with the bottom membranes attached to the coverslip oriented in the background. (See related article on p. 9102.)