Cover photograph (Copyright © 2005, American Society for Microbiology. All Rights Reserved.): Transgenic tadpoles overexpressing a dominant negative form of steroid receptor coactivator 3 (SRC3) fail to undergo thyroid hormone-induced metamorphic changes. Top left, wild-type tadpole treated with thyroid hormone; top right, transgenic tadpole treated with thyroid hormone; bottom, transgenic tadpole which failed undergo tail resorption during natural development. (See related article in July 2005, vol. 25: issue 13, p. 5712.)