Cover photograph (Copyright © 2005, American Society for Microbiology. All Rights Reserved.): A stress response pathway whereby calcium-dependent kinases inhibit the repressive activity of histone deacetylases 4 and 5 derepresses the MEF2 transcription factor and activates genes involved in pathological cardiac growth and remodeling, resulting in the hypertrophic heart shown. (See related article in October 2004, issue 19: vol. 24, p. 8467..)