Cover photograph (Copyright © 2007, American Society for Microbiology. All Rights Reserved.): Crystal structure of an MA3 domain of Pdcd4 that shows how Pdcd4 inhibits eukaryotic translation initiation factor 4A (eIF4A)-mediated translation by mimicking the structure of eIF4G, which allows it to compete for binding to eIF4A. Shown is the surface of the molecule overlaid on a cartoon highlighting the positions of residues known to be required for the Pdcd4-eIF4A interaction (blue on yellow). (See related article on page 147.)