Cover photograph (Copyright © 2008, American Society for Microbiology. All Rights Reserved.): Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming growth factor β-mediated transcription repression. In the model, the DNA sequence is the entire upstream p53 regulatory element (p53 dimer binding site), with the Smad binding sequence underlined in red. (See related article on page 1988.)