Cover photograph (Copyright © 2008, American Society for Microbiology. All Rights Reserved.): Live-cell imaging of human MRE11 fused to yellow fluorescent protein following laser-induced DNA damage. The localization of human MRE11 to DNA double-strand breaks is dependent on a glycine-arginine-rich region. Fluorescence was monitored over 5 minutes by live-cell microscopy using a laser-scanning confocal microscopy (Olympus FV1000). (See related article on page 3058.)