About This Cover
Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): Fluorescence recovery after photobleaching studies for Polo-like kinase 1 reveals distinct subcellular dynamics at different mitotic structures. Enhanced green fluorescent protein-Plk1 localized at interphase and mitotic centrosomes, kinetochores, and midbodies was photobleached, and its reappearance was imaged over time. These studies showed that the same protein kinase, known to be critical for proper mitotic function, can change its mobility by over an order of magnitude depending on its location. Furthermore, the kinase activity of Plk1 enhances its release from centrosomes once mitosis starts and stimulates its subsequent binding to late mitotic structures, providing a unidirectional arrow for mitotic progression. A montage of the images is shown. (See related article on page 3134.)
[Table of Contents]
Copyright © 2009 by the American Society for Microbiology. For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»